http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Poster Session : PS 1500 ; Allergy : A Case of Cefotiam-Induced Contact Urticaria Syndrome
( Da Woon Sim ),( Seung Hun Kim ),( Yun Ah Jeong ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Contact urticaria syndrome is a group of systemic allergic reactions usually appearing on the skin within minutes of contact with various substances. Reports of contact urticaria syndrome caused by a variety of compounds, such as foods, preservatives, fragrances, plant, animal products, and metals, have been made. We report here a case of contact urticaria syndrome induced by an antibiotic. A 32-year-old woman was presented to our allergy clinic due to urticaria on both hands, dyspnea with wheezing, abdominal pain and dizziness, which had begun 3 months before. Urticaria on both hands appeared at first and systemic allergic symptoms were followed subsequently. She was a nurse and the symptoms occurred within 10 minutes whenever she prepared drip infusions with antibiotics, such as cefotiam and netilmycin. Skin prick tests with cefotiam, netilmycin and penicillin were performed. The test showed a positive wheal (23.4 X 23.2 mm) and fiare reaction (49.9 X 49.6 mm) to 3 mg/mL cefotiam, a positive wheal (5.2 X 5.0 mm) and fiare reaction (21.7 X 21.5 mm) to 10000 IU/ ml penicillin and a negative reaction to 2.5 mg/mL netilmycin. Intradermal test to netilmycin was also negative. Saline and 1 mg/mL histamine were used as negative and positive controls. She refused drug provocation test. The case was diagnosed with cefotiam-induced contact urticaria syndrome, based on typical symptoms after contact to cefotiam and the positive skin test. Under a certain situation, it is needed to consider contact urticaria syndrome to medications in healthcare workers.
What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?
Da Woon Sim,Dong Jun Son,Eunae Cho,Sung Kyu Choi,Sang Soo Shin,Chung Hwan Jun 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.2
Background/Aims: Although eosinophilic liver infiltration (ELI) is not rare, few data exist regarding its clinical characteristics and etiology. Therefore, we evaluated these aspects to better understand the clinical implications of this lesion type, which is reasonably common in Korea. Methods: Patients suspected of having ELI, based on abdominal computed tomography results obtained between January 2010 and September 2017, were enrolled in this retrospective study. The presumptive etiologies of ELI were categorized as parasite infections, hypereosinophilic syndrome (HES), eosinophilic granulomatosis with polyangiitis (EGPA), malignancies, and unidentified. Clinical courses and treatment responses were also evaluated. Results: The mean age of the enrolled patients (male, 237/328) was 62 years. Most patients (63%) were diagnosed incidentally and had peripheral eosinophilia (90%). Only 38% of the enrolled patients (n=126) underwent further evaluations to elucidate the etiology of the suspected ELI; 82 (25%) had parasite infections, 31 (9%) had HES, five (2%) had EGPA, and five (2%) had drug reactions in conjunction with eosinophilia and systemic symptoms. Almost half of the other enrolled patients had cancer. Radiologic resolution was achieved in 191 patients (61%; median time to radiologic resolution, 185 days). Resolution of peripheral eosinophilia was achieved in 220 patients (79%). In most cases, the course of ELI was benign. Conclusions: This large ELI study is unique in that the incidence rate, underlying diseases, and clinical courses were comprehensively evaluated. Clinicians should investigate the etiology of ELI, as several of the underlying diseases require intervention rather than observation.
심다운 ( Da Woon Sim ),이재현 ( Jae Hyun Lee ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.1
The concept of personalized medicine for disease diagnosis, treatment, and management, considering individual variability, including susceptibility, clinical manifestations, and drug responsiveness, is a global emerging trend in medicine, which is also inevitable. However, clinical applications of personalized medicine in the real-world practice have been limited to certain cancers so far. Furthermore, this new concept to the diagnosis and treatment of adult asthma has not been applied to clinical use. Asthma is a multifactorial and heterogeneous disease. It seems to encompass a broad spectrum of clinical manifestations with different underlying pathophysiological mechanisms. Thus, it is not easy to categorize by their clinical features alone. Endotypical categorization that considering specific pathophysiological mechanisms will be more helpful in applying the concept of personalized medicine. The success of personalized medicine depends on patient selection for precise prescription of asthma medications. In the recent years, many investigators and physicians have devoted a lot of effort to the discovery of reliable biomarkers in asthmatic patients, which will be able to actualize the personalized medicine in near future. Despite such great efforts toward investigation of good biomarkers, few things have turned out to be practical in the clinic. Easily interpretable biomarkers of asthma are necessary to assess early detection, determination of treatment, prognosis prediction, and monitoring of exacerbation. Herein, we review recent studies regarding disease classifications and biomarkers of asthma. (Allergy Asthma Respir Dis 2016;4:4-13)
천식 환자에서 흡입용 스테로이드 장기 사용의 시상하부-뇌하수체-부신축 억제 효과
심다운 ( Da Woon Sim ),최인선 ( Inseon S Choi ),김승훈 ( Seung Hun Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.4
Purpose: Long-term treatment with inhaled steroids (ICS), especially fluticasone that developed lately, may suppress the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the relationship between ICS use and HPA axis suppression in asthmatics under ICS treatment for average 4.5 years. Methods: The medical records of 129 adult asthmatics who received ICS treatment for 6 months or more and underwent a corticotropin stimulation test from January 2005 to August 2013 were retrospectively reviewed. Results: The patients received ICS only (n=87) were found to have an abnormal response to the corticotropin test in as high as 32.2%, and those received ICS in combination with oral steroids (n=42) had a significantly higher prevalence of the response (71.4%, P<0.001). Abnormal responses to corticotropin occurred depending on ICS daily doses (low, n=8, 12.5%; medium, n=19, 36.8%; high, n=102, 49.0%; X2=4.384, P=0.036). Among the subjects received ICS only, nasal steroid doses (P=0.016) but not ICS doses (P=0.159) were significantly higher in those with abnormal responses than the others. Among all the subjects, oral steroid use (odds ratio [OR], 4.27; 95% confidence interval [CI], 2.35-11.80; P<0.001) and nasal steroid dose (OR, 1.02; 95% CI, 1.00-1.04; P=0.015) were significant risk factors for HPA axis suppression. Conclusion: One-third of asthmatics under long-term treatment with ICS showed a suppression of the HPA axis in a dose-dependent manner. Oral or nasal steroid use may be a risk factor for the suppression. However, since our results may have been overestimated due to subject selection bias, further prospective case-control studies are warranted.
심연옥(Sim Yeon-Ok),금다운(Keum Da-Woon) 한복문화학회 2016 韓服文化 Vol.19 No.3
This study is to progress the site inspection, based on lodgement area of hemp production which can be identified the terms as intangible cultural asset of national, municipal, and regional and hemp village in 2015. Also, it compared the current state of transmission of hemp at each region, breed and characteristic of hemp textile. The function of hemp weaving at four regions is designated as intangible cultural asset, and some places like Andong, Bonghwa, Geochang, Dangjin, Muju, Boseong, Namhae, and Jeongseon are where hemp is weaved actively up to now at unit of village. The age of hemp producer at each region is from 50"s, but most of them are over 70"s. Compare to other areas there are many hemp producers in Andong, Geochang, Namhae, and Jeongseon, and wide range of ages. Hemp, which is produced all over the country, is mainly being weaved as 35~38 ㎝ in width, 4~6sae (1sae : warp / 80). In the course of warping, material of starch is being used variously for each region, and the modified loom is mostly being used. The hemp is the main material of shroud. Even in places like Andong, where weaved hemp of various breed, the weaving of Musam and Iknaengi were stopped and produced according to Saengnaengi, due to hassle of the process. Saengnaengi is being produced in various sae, from 5 to 15. Saengnaengi style hemp is being produced even in Bonghwa and Cheongdo, and it is called as Hwangpo and Hwangjipo in Cheongdo. Musam in Andong has similar progress with hemp of other regions, and Musam is produced in Bonghwa. No other regions have any similar weaving method of Iknaengi in Andong.
Relationship between Perceived Oral Symptoms and Oral Health Status
Seon-Ju Sim,Ji-Yoon Hwang,Yeo-Joo Yoon,Mina Park,Da-woon Jung,Ja-Young Moon 대한임상예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.3
Objective: The purpose of this study was to examine the relationship between perceived oral health and oral health status. Methods: The oral examination and survey data of 219 subjects over 40 years of age were analyzed. All individuals were interviewed by self-reporting questionnaire that focused on previous diseases, vascular risk factors (hypertension, diabetic mellitus, cardiac disease), smoking and drinking habits, social history, BMI, the frequency of daily tooth brushing and the presence of regular dental visits. Dental survey was conducted in relations to the number of teeth, DMFT index, and the pocket depth. Results: 1. Better perceived oral health status was likely to rate their periodontal conditions as good with more teeth remaining and less dental caries. 2. With increasing DMFT index, perceived oral health and periodontal conditions were rated poorly with a severe dry mouth experience. 3. With high CPITN index, perceived periodontal conditions were rated poorly with less number of teeth remaining and a severe dry mouth condition. 4. In a multivariate analysis adjusted for socioeconomic status, hypertension, diabetes mellitus, frequency of daily tooth brushing and regular dental visits, the better perceived oral health status is, the lower DMFT index is. Conclusion: Self-rated oral health is a simple measure and reflects not only the objective oral status but also the socioeconomic status and the psychological effects of oral health. Thus, we should actively use the perceived oral health criteria to promote the nation's oral health.