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BINARY RELATIONS, INTERVAL STRUCTURES AND JOIN SPACES
Corsini, Piergiulio 한국전산응용수학회 2002 Journal of applied mathematics & informatics Vol.10 No.1
We study correspondences between interval structures and hyperstructures.
Symposium 2 : Lipid-lowering Therapy ; Pleiotropic Effects-isoprenoid Proteins
( Alberto Corsini ),( Stefano Bellosta ),( Rodolfo Paoletti ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolemic properties. However, because mevalonic acid (MVA), the product of the e
Flow solutions around rectangular cylinders: The question of spatial discretization
Roberto Corsini,Diego Angeli,Enrico Stalio,Sergio Chibbaro,Andrea Cimarelli 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.1
The aerodynamics of blunt bodies with separation at the sharp corner of the leading edge and reattachment on the body side are particularly important in civil engineering applications. In recent years, a number of experimental and numerical studies have become available on the aerodynamics of a rectangular cylinder with chord-to-thickness ratio equal to 5 (BARC). Despite the interest in the topic, a widely accepted set of guidelines for grid generation about these blunt bodies is still missing. In this work a new, well resolved Direct Numerical Simulation (DNS) around the BARC body at Re=3000 is presented and its results compared to previous DNSs of the same case but with different numerical approaches and mesh. Despite the simulations use different numerical approaches, mesh and domain dimensions, the main discrepancies are ascribed to the different grid spacings employed. While a more rigorous analysis is envisaged, where the order of accuracy of the schemes are kept the same while grid spacings are varied alternately along each spatial direction, this represents a first attempt in the study of the influence of spatial resolution in the Direct Numerical Simulation of flows around elongated rectangular cylinders with sharp corners
Special lecture : Pharmacodynamic and Pharmacokinetic Properties of statins
( Alberto Corsini ),( Rodolfo Paoletti ),( Stefano Bellosta ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have generally been attributed to their hypocholesterolemic properties. However, because mevalonic acid, the product of the enzyme
Transcatheter Mitral Valve Implantation in Open Heart Surgery: An Off-Label Technique
Jacopo Alfonsi,Giacomo Murana,Anna Corsini,Carlo Savini,Roberto Di Bartolomeo,Davide Pacini 대한흉부외과학회 2017 Journal of Chest Surgery (J Chest Surg) Vol.50 No.6
Extensive mitral annulus calcifications are considered a contraindication for valve surgery. We describe the case of a 76-year-old female with severe mitral and aortic stenosis associated with extensive calcifications of the heart. The patient underwent an open mitroaortic valve replacement using transcatheter aortic valve implantation with an Edwards SAPIEN XT valve (Edwards Lifesciences Corp., Irvine, CA, USA) in the mitral position. T he a ortic valve was replaced u sing a s tentless v alve p rosthesis (LivaNova S OLO; L ivaNova PLC, London, UK). Postoperative echocardiography showed that the prosthetic valve was in the correct position and there were no paravalvular leaks. A bailout open transcatheter valve implantation can be considered a safe and effective option in selected cases with an extensively calcified mitral valve.
Diatom Allantoin Synthase Provides Structural Insights into Natural Fusion Protein Therapeutics
Oh, Juntaek,Liuzzi, Anastasia,Ronda, Luca,Marchetti, Marialaura,Corsini, Romina,Folli, Claudia,Bettati, Stefano,Rhee, Sangkee,Percudani, Riccardo American Chemical Society 2018 ACS CHEMICAL BIOLOGY Vol.13 No.8
<P>Humans have lost the ability to convert urate into the more soluble allantoin with the evolutionary inactivation of three enzymes of the uricolytic pathway. Restoration of this function through enzyme replacement therapy can treat severe hyperuricemia and Lesch-Nyhan disease. Through a genomic exploration of natural gene fusions, we found that plants and diatoms independently evolved a fusion protein (allantoin synthase) complementing two human pseudogenes. The 1.85-Å-resolution crystal structure of allantoin synthase from the diatom <I>Phaeodactylum tricornutum</I> provides a rationale for the domain combinations observed in the metabolic pathway, suggesting that quaternary structure is key to the evolutionary success of protein domain fusions. Polyethylene glycol (PEG) conjugation experiments indicate that a PEG-modified form of the natural fusion protein provides advantages over separate enzymes in terms of activity maintenance and manufacturing of the bioconjugate. These results suggest that the combination of different activities in a single molecular unit can simplify the production and chemical modification of recombinant proteins for multifunctional enzyme therapy.</P> [FIG OMISSION]</BR>
Andrea Crivellini,Alessandra Nigro,Alessandro Colombo,Antonio Ghidoni,Gianmaria Noventa,Andrea Cimarelli,Roberto Corsini 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.34 No.1
In this work the numerical results of the flow around a 5:1 rectangular cylinder at Reynolds numbers 3 000 and 40 000, zero angle of attack and smooth incoming flow condition are presented. Implicit Large Eddy Simulations (ILES) have been performed with a high-order accurate spatial scheme and an implicit high-order accurate time integration method. The spatial approximation is based on a discontinuous Galerkin (dG) method, while the time integration exploits a linearly-implicit Rosenbrock-type Runge-Kutta scheme. The aim of this work is to show the feasibility of high-fidelity flow simulations with a moderate number of DOFs and large time step sizes. Moreover, the effect of different parameters, i.e., dimension of the computational domain, mesh type, grid resolution, boundary conditions, time step size and polynomial approximation, on the results accuracy is investigated. Our best dG result at Re=3 000 perfectly agrees with a reference DNS obtained using Nek5000 and about 40 times more degrees of freedom. The Re=40 000 computations, which are strongly under-resolved, show a reasonable correspondence with the experimental data of Mannini et al. (2017) and the LES of Zhang and Xu (2020).