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Silvia Franchini,Umberto M. Battisti,Claudia Sorbi,Annalisa Tait,Andrea Cornia,정낙신,이상국,송자영,Roberta Loddo,Silvia Madeddu,Giuseppina Sanna,Livio Brasili 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.5
Nucleoside analogues play an important role inantiviral, antibacterial and antineoplastic chemotherapy. Herein we report the synthesis, structural characterizationand biological activity of some 40-C-methyl- and -phenyldioxolane-based nucleosides. In particular, a and banomers of all natural nucleosides were obtained andcharacterized by NMR, HR-MS and X-ray crystallography. The compounds were tested for antimicrobial activityagainst some representative human pathogenic fungi, bacteriaand viruses. Antitumor activity was evaluated in alarge variety of human cancer cell-lines. Although most ofthe compounds showed non-significant activity, 23aweakly inhibited HIV-1 multiplication. Moreover, 22a and32a demonstrated a residual antineoplastic activity, interestinglylinked to the unnatural a configuration. Theseresults may provide structural insights for the design ofactive antiviral and antitumor agents.