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        Thermoelectric Performance of Poly(3-hexylthiophene) Films Doped by Iodine Vapor with Promising High Seebeck Coefficient

        Hongfei Zhu,Congcong Liu,Haijun Song,Jingkun Xu,Fangfang Kong,Jianmin Wang 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2

        Poly(3-hexylthiophene) (P3HT) films doped with iodine vapor have been prepared by casting a P3HT solution on glass substrates and their thermoelectric (TE) performances has been investigated. The maximum Seebeck coefficient and electrical conductivity of iodine-doped P3HT films were 386 μV·K−1 (at room temperature) and 4.7 × 10−1 S·cm−1, which is about five orders of magnitude higher than that of pristine P3HT films. The power factor of these iodine-doped P3HT films was estimated to be 7.0 μW·m−1·K−2 at room temperature, which is a relative high value for organic TE materials. The UV-vis spectra of iodine-doped P3HT films showed a slight red shift of the iodine-doped P3HT compared to those of pristine P3HT films. Atomic force microscopy images indicated the conformational changes in P3HT chains after treatment with iodine vapor. During this treatment, the P3HT chains self-organized into a more ordered structure, this organization improved the charge carrier transport capability and the TE performance of P3HT the films.

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        Genetic Diversity and Population Structure of the Xanthomonas campestris pv. campestris Strains Affecting Cabbages in China Revealed by MLST and Rep-PCR Based Genotyping

        Guo Chen,Congcong Kong,Limei Yang,Mu Zhuang,Yangyong Zhang,Yong Wang,Jialei Ji,Zhiyuan Fang,Honghao Lv 한국식물병리학회 2021 Plant Pathology Journal Vol.37 No.5

        Xanthomonas campestris pv. campestris (Xcc) is the causal agent of black rot for cruciferous vegetables worldwide, especially for the cole crops such as cabbage and cauliflower. Due to the lack of resistant cabbage cultivars, black rot has brought about considerable yield losses in recent years in China. Understanding of the pathogen features is a key step for disease prevention, however, the pathogen diversity, population structure, and virulence are largely unknown. In this study, we studied 50 Xcc strains including 39 Xcc isolates collected from cabbage in 20 regions across China, us- ing multilocus sequence genotyping (MLST), repetitive DNA sequence-based PCR (rep-PCR), and pathogenicity tests. For MLST analysis, a total of 12 allelic profiles (AP) were generated, among which the largest AP was AP1 containing 32 strains. Further cluster analysis of rep-PCR divided all strains into 14 DNA groups, with the largest group DNA I comprising of 34 strains, most of which also belonged to AP1. Inoculation tests showed that the representative Xcc strains collected from diverse regions performed differential virulence against three brassica hosts compared with races 1 and 4. Interestingly, these results indicated that AP1/DNA I was not only the main pathotype in China, but also a novel group that differed from the previously reported type races in both genotype and virulence. To our knowledge, this is the first extensive genetic diversity survey for Xcc strains in China, which provides evidence for cabbage resistance breeding and opens the gate for further cabbage-Xcc interaction studies.

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        Efficient starvation therapy with three-pathway blocking in combination with PTT/CDT for TME reversal and tumor apoptosis

        Mengchao Ding,Xiaoying Kong,Weiyan Chen,Lei Yan,He Huang,Zunzhou Lv,Peng Jiang,Ali Mu,Congcong Huang,Jinsheng Shi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-

        Single cancer starvation therapy (ST) strategy can’t achieve satisfactory anti-tumor effect, mainly due tothe diversified nutritional sources of tumor cells. Herein, CuS@Axitinib-SiO2@2-Deoxy-D-glucose(2-DG)-CaCO3-RGD nanoparticles (CADCR NPs) were prepared for three-pathway blocking for efficient starvationtherapy as well as reinforced photothermal therapy (PTT) and chemodynamic therapy (CDT). AfterCADCR NPs were targeted to tumor cells, CaCO3 was ruptured in the acidic environment, releasingCa2+ to chelate glutamine and cutting off the glutamine metabolic pathway of the tumor. 2-DG was alsoreleased from mesoporous SiO2 and restrained the glycolytic pathway of tumor cells. In addition, underthe thermal stimulus of near-infrared irradiation, axitinib was released from CuS NPs, which inhibited theproliferation of tumor blood vessels, ultimately inhibiting the aerobic respiratory pathway of tumor cells. Interestingly, CADCR NPs also showed potential to reshape the tumor microenvironment (TME) and promotedthe transformation of macrophages from M2 to M1 type, increasing the expression of CD8+ T cellsin the tumor site. In conclusion, CADCR NPs achieve severe tumor starvation by simultaneously interferingwith three energy metabolic pathways, and further enhance tumor treatment with the aid of PTT,CDT, and TME improvement, which exhibits great potential for clinical cancer therapy.

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