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Dool-Ri Oh,Yujin Kim,Kyo-Nyeo Oh,Eun-Jin Choi,Donghyuck Bae,Yonguk Kim,Chulyung Choi 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Vaccinium bracteatum Thunb. (VB) are a component of traditional herbal medicines found in East Asia, specially, fruit is commonly known as the oriental blueberry in Korea. The present study aimed to evaluate the mechanisms underlying the antidepressant, preventing oxidative stress and insomnia of water extract of VB fruit (VBFW) using in vitro and in vivo models. First, since the serotonin neurotransmitter system is hypothesized to contribute to depression, we studied the effects of water extract from VBFW on the serotonin receptors (5-HTRs)-related activities in Chinese hamster ovary (CHO)-K1 cells transfected with the human 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT6, and 5-HT7 receptors. VBFW produced the antagonistic effects at the 5-HT2A receptors, and showed the agonistic effects at the 5-HT1A receptors, which could possibly produce antidepressant-like effects. Next, it was studied by using animal models predictive of antidepressant-like effects. The effects of VBFW were studied in normal and 4-Chloro-DL-phenylalanine methyl ester hydrochloride (PCPA)-induced serotonin-depleted mice. These results suggest that evidence of the antidepressant-like effects of VBFW includes the decreased immobility time during the forced swim test (FST) in mice that is caused by a decrease in the levels of serum corticosterone (CORT), as well as increased serotonergic neurotransmission. Moreover, this study provides an evidence that the antidepressant-like effects of VBFW in mice exposed to chronic restraint stress (CRS) exhibited significantly reduced immobility time and increased swimming times in the FST, and increased locomotor activity in the OFT. In addition, CRS mice treated with VBFW exhibited significantly decreased the hypothalamic-pituitary-adrenal (HPA) axis and oxidative stress (e.g., glutamate and MDA levels), but upregulated brain monoamine neurotransmitters (e.g., 5-HT, dopamine, norepinephrine) and the extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) phosphorylation. Furthermore, since depression can lead to sleep problems, the sedative and hypnotic effects of VBFW in an animal model and alterations to the γ-aminobutyric acid (GABA)-ergic system were also studied. VBFW significantly reduced the sleep latency and increased the total sleep duration during pentobarbital-induced sleeping behaviors in mice, which are possibly associated with upregulation of the glutamate decarboxylase (GAD)65/67 protein and GABAA receptor subunits (α5, β1, and β2). In conclusion, the antidepressant effects of VBFW were possibly mediated by regulation monoamine neurotransmitters in basis of their effects on 5-HT2A and 5-HT1A receptors and ERK/Akt phosphorylation, and prevention of HPA axis dysfunction. Furthermore, VBFW induces sedative and hypnotic effects by regulating the serotonergic and GABAA-ergic systems. These results suggest that the VBFW might be an effective natural therapeutic agent for stress and depression disorder.
Pullman bed를 적용한 천장재 차음시험에 관한 실험적 고찰
최둘(Dool Choi),김항(Hang Kim),구희모(Hee-Mo Goo),문순성(Soon-Sung Moon),김정식(Jung-Sik Kim) 한국소음진동공학회 2015 한국소음진동공학회 학술대회논문집 Vol.2015 No.4
Studies on the sound insulation performance of the wall panel was performed of a lot, but the situation for the lack of sound insulation tests of ceiling panel. Also recently give comfort to the passenger within a residential party applying pullman bed, but this study is a situation which has not been made much. In this paper compared and analyzed the sound insulation performance in accordance with applicable pullman bed or not, As a result the performance was found to significantly decreased when applying the pullman bed.
Oh, Dool-Ri,Kim, Yujin,Choi, Eun-Jin,Jung, Myung-A,Oh, Kyo-Nyeo,Hong, Ji-Ae,Bae, Donghyuck,Kim, Kwangsu,Kang, Huwon,Kim, Jaeyong,Kim, Young Ran,Cho, Seung Sik,Choi, Chul-Young World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.2
<P>The fruit of <I>Vaccinium bracteatum</I> Thunb. (VBF) is commonly known as the oriental blueberry in Korea. The aim of this study was to evaluate the antidepressant-like effects of water VBF extract (VBFW) in a mouse model of chronic restraint stress (CRS) and to identify the underlying mechanisms of its action. The behavioral effects of VBFW were assessed in the forced swim test (FST) and open field test (OFT). The levels of serum corticosterone (CORT), brain monoamines, in addition to the extracellular signal-regulated kinases (ERKs)/protein kinase B (Akt) signaling pathway were evaluated. VBFW treatment significantly reduced the immobility time and increased swimming time in FST without altering the locomotor activity in unstressed mice. Furthermore, CRS mice treated with VBFW exhibited a significantly decreased immobility time in FST and serum CORT, increased locomotor activity in OFT, and enhanced brain monoamine neurotransmitters. Similarly, VBFW significantly upregulated the ERKs/Akt signaling pathway in the hippocampus and PFC. In addition, VBFW may reverse CORT-induced cell death by enhancing cyclic AMP-responsive element-binding protein expression through the up-regulation of ERKs/Akt signaling pathways. In addition, VBFW showed the strong antagonistic effect of the 5-HT<TEX>$ _{2\text{A}}$</TEX> receptor by inhibiting 5-HT-induced intracellular Ca<TEX>$ ^{2+}$</TEX> and ERK1/2 phosphorylation. Our study provides evidence that antidepressant-like effects of VBFW might be mediated by the regulation of monoaminergic systems and glucocorticoids, which is possibly associated with neuroprotective effects and antagonism of 5-HT<TEX>$ _{2\text{A}}$</TEX> receptor.</P>
Oh, Dool-Ri,Kim, Yujin,Choi, Eun-Jin,Jo, Ara,Shin, Jawon,Kang, Huwon,Lee, Seul-Gi,Kim, Jaeyong,Kim, Young Ran,Choi, Chul Yung World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.7
<P>The present study evaluates the anti-oxidative stress activity of <I>Vaccinium bracteatum</I> Thunb. fruit extract (VBFW) to identify the mechanisms responsible for its antidepressant-like effects. To evaluate the antidepressant and anti-oxidant effects of VBFW, malondialdehyde (MDA), serotonin transporter (SERT), and monoamine oxidase A (MAO-A) levels were measured in a mouse model of chronic restraint stress (CRS). The underlying mechanisms preventing oxidative stress and neuronal apoptosis were investigated using <I>in vitro</I> models of hydrogen peroxide (H<SUB>2</SUB>O<TEX>$ _{2})$</TEX>-induced neuronal damage. The results showed that VBFW treatment (200<TEX>$ \,$</TEX>mg/kg) significantly reduced MDA, SERT, and MAO-A levels in the prefrontal cortex of CRS mice. Furthermore, VBFW (30<TEX>$ \,$</TEX><TEX>$ \mu $</TEX>g/mL) exhibited protective effects against H<SUB>2</SUB>O<SUB>2</SUB>-induced cell death via inhibition of the H<SUB>2</SUB>O<SUB>2</SUB>-induced increase in Bax and decrease in Bcl-2 levels within the mitochondria of SH-SY5Y cells. Furthermore, VBFW (10 and 30<TEX>$ \,$</TEX><TEX>$ \mu $</TEX>g/mL) exerted protective effects against H<SUB>2</SUB>O<SUB>2</SUB>-induced cell death through inhibition of key mitochondria-associated apoptotic proteins such as cytochrome c, caspase-3 and PARP. Additionally, VBFW (10 and 30<TEX>$ \,$</TEX><TEX>$ \mu $</TEX>g/mL) could improve the activity of anti-oxidant enzymes (such as SOD and catalase) in H<SUB>2</SUB>O<SUB>2</SUB>-treated SH-SY5Y cells. These results suggest that the antidepressant and anti-oxidant effects of VBFW might be mediated by the regulation of SERT and MAO-A, and possibly associated with regulation of oxidative stress-induced apoptosis.</P>