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- 저자 : Choi Baekgyu (검색결과 3 건)
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Choi Baekgyu,Kang Chang Kyung,Park Seongwan,Lee Dohoon,Lee Andrew J.,Ko Yuji,Kang Suk-Jo,Kang Kyuho,Kim Sun,Koh Youngil,Jung Inkyung 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Clonal hematopoiesis of indeterminate potential (CHIP), a common aging-related process that predisposes individuals to various inflammatory responses, has been reported to be associated with COVID-19 severity. However, the immunological signature and the exact gene expression program by which the presence of CHIP exerts its clinical impact on COVID-19 remain to be elucidated. In this study, we generated a single-cell transcriptome landscape of severe COVID-19 according to the presence of CHIP using peripheral blood mononuclear cells. Patients with CHIP exhibited a potent IFN-γ response in exacerbating inflammation, particularly in classical monocytes, compared to patients without CHIP. To dissect the regulatory mechanism of CHIP (+)-specific IFN-γ response gene expression in severe COVID-19, we identified DNMT3A CHIP mutation-dependent differentially methylated regions (DMRs) and annotated their putative target genes based on long-range chromatin interactions. We revealed that CHIP mutant-driven hypo-DMRs at poised cis-regulatory elements appear to facilitate the CHIP (+)-specific IFN-γ-mediated inflammatory immune response. Our results highlight that the presence of CHIP may increase the susceptibility to hyperinflammation through the reorganization of chromatin architecture, establishing a novel subgroup of severe COVID-19 patients.
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BaekGyu Kim,Jin Yeong Song,Do Young Kim,Jun Gyu Kim,Jun‑Yeop Lee,Dongwhi Choi,Sang Min Park 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.6
Transparent triboelectric nanogenerators (TENGs) are promising sustainable energy sources utilizable in optoelectronic devices. Here, we report a highly transparent TENG realized using AgNW-spray-deposition with a surfactant (ASDS). The ASDS process achieved coffee-ring-free AgNW with superior light transmittance of 87.6% and sheet resistance of 12.4 Ω/sq (ΦFOM = 21.5 × 10−3Ω−1), and possessed a high degree of design flexibility on 2D, 3D-curved substrates. The AgNW-spray-deposition with surfactant based transparent TENG (AT-TENG) with hydrophobic characteristics enables to generate electrical signals through solid–solid and solid–liquid contact electrification. As proof-of-concept applications, a self-powered bendable tactile sensor, which exploited biomechanical energy from finger-touch motion, and hybrid energy harvester to concurrently harvest solar and raindrop energy, are demonstrated. The self-powered bendable tactile sensor transformed the finger-touch into electrical energy recognized by the computer, and was utilized as a transparent keypad. The hybrid energy harvester, which is AT-TENG unified with a photovoltaic system, generates electricity from light and falling-droplets. The AT-TENG does not significantly degrade the output performance of photovoltaic system, and their parallel connection enables to achieve the maximum output voltage of 7.0 V. AT-TENGs have advantages such as simplicity of fabrication, outstanding transparency, and superior electrical performance, and have potential for future applications in wearable electronics and smart-home systems.
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Past, Present, and Future of Brain Organoid Technology
Koo, Bonsang,Choi, Baekgyu,Park, Hoewon,Yoon, Ki-Jun Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.9
Brain organoids are an exciting new technology with the potential to significantly change our understanding of the development and disorders of the human brain. With step-by-step differentiation protocols, three-dimensional neural tissues are self-organized from pluripotent stem cells, and recapitulate the major millstones of human brain development in vitro. Recent studies have shown that brain organoids can mimic the spatiotemporal dynamicity of neurogenesis, the formation of regional neural circuitry, and the integration of glial cells into a neural network. This suggests that brain organoids could serve as a representative model system to study the human brain. In this review, we will overview the development of brain organoid technology, its current progress and applications, and future prospects of this technology.
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