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무배란성 불임환자에 있어서 골반 초음파 추적조사에 의한 Gonadotropin 치료
이두룡,김덕만,조치흠 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
Ovarian follicular growth was monitored by ultrasound. Ovulatioin induction in 25 cycles of 13 anovulatory infertility patients were performed. These women were treated with clomiphene citrate, human menopausal gonadotropin(hMG) and human chorionic gonadotropin(hCG) for anovulatry infertility. The amount of gonadotropins administered were based exclusively on the results of the ultrasound examiinations. Twelve pregnancies were obtained. with 12 singletons, resulting in accumulative pregnancy rate about 92.3%. Ultrasoound can be helpful in the determination of the best time for induction of ovulation and effectively to control gonadotropin therapy in the majority of cases.
최신임상강좌 : 생식세포난소종양 (Ovarian Germ Cell Tumors)의 최신 처치 지견
조치흠 ( Chi Heum Cho ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
Significant improvements in the management of ovarian germ-cell tumors have been achieved during the past two decades. The development of more effective chemotherapeutic regimens is clearly the leading cause for improved outcome for these patients. In add
조치흠(Chi Heum Cho),차순도(Soon Do Cha),백원기(Won Ki Baek),권건영(Kun Young Kwon),배인수(In Soo Bae) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
Objective : Apoptosis or programmed cell death is a normally physiological cell suicide program that is highly conserved among all animals. We previously evaluated overexpression of c-IAP1(Inhibitor of Apoptosis Protein) in ovarian carcinomas compared with normal ovaries. In this study, we demonstrate evidence for the involvement of c-IAP2 in ovarian carcinomas. Methods : Fresh 9 normal ovaries, 5 benign ovarian cysts and 13 ovarian carcinomas were obtained from routine gynecologic surgeries carried out for benign and malignant ovarian tumors. They were examined for the presence of c-IAP2 by RT-PCR(Reverse Transcriptase Polymerase Chain Reaction), Western blot analysis and immunohistochemical stains. Results : Nine of 14 normal and benign ovarian tumors were negative and 11 of 13 ova rian carcinomas were positive for c-IAP2 by RT-PCR. Positive RT-PCR for c-IAP2 was seen in 11/13 of ovarian carcinomas, a significantly higher percentage than in normal and benign ovarian tumors(5/14). All of these tumors showed strong positive for c-IAP2 by western blot and immunohistochemical staining. Whereas negative RT-PCR for c-IAP2 was seen in 9/14 of normal and benign ovarian tumors, a significantly higher percentage than ovarian carcinomas(2/13). Of these 9 negative samples, 6 had positive Western blot and immunohistochemical stains. There was weak concordance of the result. But expression of c-IAP2 in normal ovarian tissue was localized exclusively in the corpus luteum. Therefore, c-IAP2 may play important role in determining the fate of the follicular destiny. There was no expression in normal ovarian stroma cells for c-IAP2. Conclusions : These findings suggest that c-IAP2 is expressed in ovarian carcinomas and emerging role in cancer. The c-IAP2 expression has been investigated in the normal ovary, where apoptosis is thought to play an important role in ovulation.
조치흠 ( Chi Heum Cho ),( Hyun Gyo Lee ),( Ji Min Lee ),( So Jin Shin ),( Sang Hoon Kwon ),( Gi Su Lee ),( Chang Ho Song ),( Eun Som Choi ),( Soon Do Cha ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Objective: The aim of this study was to investigate the anti-proliferative effect of the salinomycin in cell proliferation and apoptosis in primary cultured human uterine leiomyoma cells. Methods: Cell viability was measured by MIT (3-(4 ,5-dimelhyllhiazol-2-yl)-2,S-diphenyltetrazolium bromide) assay. Caspase-3 activity assay and DNA fragmentation assay were performed to determine the effect of apoptosis. The expression of apoptosis regulatory-related proteins was evaluated by western blot. Results: The cell viability and proliferation of uterine leiomyoma cells were significantly reduced by salinomycin treatment in a dose-dependent manner. DNA fragmentation assay results showed apoptotic cell death after salinomycin incubation. Salinomycin activated caspase-3, -8, and -9, causing apoptosis in uterine leiomyoma cells. Down-regulation of Bcl-2, XIAP, and FLIP with a concomitant increase in Bax, Fas, and DR5 were observed. Conclusion: These results provided the first evidence that salinomycin induce both intrinsic and extrinsic apoptosis. Therefore, salinomycin may be a promising chemopreventive and therapeutic agent against human uterine leiomyoma.