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P003 : Blood type B-specific difference in skin phenotypes of Korean women
( Jang Hee Oh ),( Inn Gyung Oh ),( Chi Hyun Park ),( Min Kyeong Shin ),( Serah Lee ),( Dong Hun Lee ),( Mira Choi ),( Seon Pil Jin ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: ABO blood group antigen expression was found on many tissues including the granular of the epidermis. Objectives: To investigate the blood type-specific difference in normal skin phenotypes in Korean women. Methods: Skin hydration, transepidermal water loss (TEWL), wrinkle depth, elasticity, or skin erythema/melanin index, were analyzed according to the blood type. Results: The skin hydration at buttock skin showed significantly lower in B blood type individuals than non-blood type B individuals of same young age range (20~49 yr, mean age; 34.0±9.3 yr, n=40), but TEWL of them showed no difference. However, the skin hydration and TEWL in old age range (54~84 yr, mean age; 70.4±6.2 yr, n=126) showed no B blood type-specific difference in inner-arm skin. The eye wrinkle depth in old B blood type individuals also was observed to be significantly deeper than non-B blood type individuals of same old age range. Deeper eye wrinkle was also observed in O blood type than A or AB blood type, but seemed less than B blood type. However, their skin elasticity showed no difference. The melanin index in old B blood type individuals also showed less measurement, which means bright skin color, than non-B blood type individuals, while the erythema index did not. Conclusion: In conclusion, we found that B blood type individuals probably has most distinct skin phenotypes, including less hydration, deeper eye wrinkle, and bright skin color in Korean women.
Deeper Wrinkle Formation and Less Melanin Production in Aged Korean Women with B Blood Type
( Jang-hee Oh ),( Inn-gyung Oh ),( Chi-hyun Park ),( Min Kyeong Shin ),( Se-rah Lee ),( Dong Hun Lee ),( Mira Choi ),( Seon-pil Jin ),( Hyun-sun Yoon ),( Soyun Cho ),( Jin Ho Chung ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.3
[6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway
Yao, Cheng,Oh, Jang-hee,Oh, Inn Gyung,Park, Chi-hyun,Chung, Jin Ho Springer Science and Business Media LLC 2013 Acta pharmacologica Sinica. Vol.34 No.2
<P>Aim: To investigate the effect of [6]-shogaol, an active ingredient in ginger, on melanogenesis and the underlying mechanisms. Methods: B16F10 mouse melanoma cells were tested. Cell viability was determined with the MU assay. Melanin content and tyrosinase activity were analyzed with a spectrophotometer. The protein expression of tyrosinase and microphthalmia associated transcription factor (MITF), as well as phosphorylated or total ERK1/2 and Akt were measured using Western blot. Results: Treatment of the cells with [6]-shogaol (1, 5, 10 mu mol/L) reduced the melanin content in a concentration-dependent manner. [6]-Shogaol (5 and 10 mu mol/L) significantly decreased the intracellular tyrosinase activity, and markedly suppressed the expression levels of tyrosinase and MITF proteins in the cells. Furthermore, [6]-shogaol (10 mu mol/L) activated ERK, which was known to negatively regulate melanin synthesis in these cells. Pretreatment with the specific ERK pathway inhibitor PD98059 (20 mu mol/L) greatly attenuated the inhibition of melanin synthesis by [6]-shogaol (10 mu mol/L). Conclusion: The results demonstrate that [6]-shogaol inhibits melanogenesis in B16F10 mouse melanoma cells via activating the ERK pathway.</P>
Yao, Cheng,Jin, Cheng Long,Oh, Jang-Hee,Oh, Inn Gyung,Park, Chi-Hyun,Chung, Jin Ho SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.11 No.1
<P>Melanin protects the skin against ultraviolet radiation by scattering incoming light and absorbing diverse free radicals. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigated the effect of a methanol extract of Ardisia crenata (AC) on melanogenesis in B16F10 cells. Treatment of cultured B16F10 cells with AC extract (10, 20 and 40 ?g/ml) stimulated an increase in melanin levels in a concentration-dependent manner, without cytotoxicity. Tyrosinase is key in the regulation of melanin production, thus the effect of AC extract on tyrosinase activity and protein expression was analyzed. AC extract was observed to significantly increase tyrosinase activity and protein expression in B16F10 cells. Furthermore, AC extract was found to markedly increase the protein expression of microphthalmia-associated transcription factor, which is an important transcription factor involved in tyrosinase gene expression. In addition, AC extract (40 ?g/ml) was observed to suppress the activation of extracellular signal-regulated kinase (ERK) and Akt, which negatively regulate melanin synthesis in B16F10 cells. In conclusion, to the best of our knowledge, the present study is the first to show that a methanol extract of AC stimulates melanogenesis by increasing tyrosinase expression via the inhibition of ERK and Akt. Thus, methanol extract of AC may be a potential treatment for hypopigmentation diseases and may be a candidate for skin-tanning cosmetic products.</P>
Yao, Cheng,Jin, Cheng Long,Oh, Inn Gyung,Park, Chi-Hyun,Chung, Jin Ho UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.6
<P>Melia azedarach (MA) has been used in folk medicine in Asia for the treatment of several diseases. Several constituents from MA possess anti-herpetic, anti-angiogenic and anticancer properties. The aim of the present study was to investigate the effect of a 70% ethanol extract of MA on melanogenesis and the underlying mechanisms involved. A B16F10 mouse melanoma cell line was used in our experiments. Treatment of B16F10 cells with the MA extract (10, 20 and 40 ?g/ml) increased melanin content in a concentration-dependent manner without cytotoxicity at 24 h. Further experiments indicated that the MA extract (20 ?g/ml) increased melanin content as early as at 4 h after treatment. Additionally, although the MA extract did not affect intracellular tyrosinase activity and the protein levels of tyrosinase and tyrosinase-related protein-2 (TRP-2) at 2 and 4 h after treatment, the MA extract increased TRP-1 protein expression at both time points. However, no significant effect of the MA extract treatment on TRP-1 mRNA level at the time points measured was observed. In conclusion, the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells and suggest that the MA extract can be viewed as a rapid inducer of melanogenesis, thus rendering it a potential treatment for hypopigmentation diseases including vitiligo.</P>
중·대형함정 소형·고속 표적 대응능력 향상을 위한 5인치 지향성파편탄 적용 연구
조용연(Yong Yeon Cho),최경억(Gyung Uk Choi),오지헌(Chi Hon Oh),양성훈(Sung Hoon Yang),김창기(Chang Ki Kim) 한국해군과학기술학회 2023 Journal of the KNST Vol.6 No.1
Modern warfare has been accelerating the development of smaller and faster weapon systems such as drones and unmanned surface vessels, due to the fourth industrial revolution and advancements in unmanned technology. However, the current state of the navys weapon systems is insufficient to respond to these developments. Therefore, this paper investigates the application of 5-inch Gun Directional Fragmentation Warhead as a means for medium/large surface ships to effectively respond to small, high-speed targets.