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- 저자 : Chenhui Wu (검색결과 5 건)
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Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs
Zhipeng Yao,Xiaochun Jiang,Hong Yao,Yafeng Wu,Fan Zhang,Cheng Wang,Chenxue Qi,Chenhui Zhao,Zeyu Wu,Min Qi,Jia Zhang,Xiaoxiang Cao,Zhichun Wang,Fei Wu,Chengyun Yao,Songqin Liu,Shizhang Ling,Hongping Xi 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods: We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results: We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic ntracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.
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Mingyong Liu,Chenhui Wu,Chunai Yan 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.7
Surface contact fatigue is a major failure mode of many mechanical components, such as various gear pairs, bearings, cam-follower systems, and so on. The present study aims to develop a fatigue life prediction approach for finite line contact model using machined surface topography. Based on the developed model, the effect of working conditions and lubrication parameters on the lubrication performance and fatigue life are investigated. The obtained results show that, by introducing the realistic roughness, the distribution of pressure, film thickness and stress field is significant fluctuations. Meanwhile, the location of maximum stress tends to move to subsurface. The effect of load on fatigue life is significant. Yet, the speed does not seem to have a great influence on the fatigue life in various load ranges. It is also indicated that the high ambient viscosity is beneficial to the lubrication performance and fatigue life.
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Xie Mengxiao,Wu Zhijiao,Ying Shuai,Liu Longfei,Zhao Chenhui,Yao Chunlei,Zhang Zhiwei,Luo Can,Wang Wenbo,Zhao Dan,Zhang Jing,Qiu Wen,Qiu Wen 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Glomerular mesangial cell (GMC) proliferation is a histopathological alteration in human mesangioproliferative glomerulonephritis (MsPGN) or in animal models of MsPGN, e.g., the rat Thy‐1 nephritis (Thy-1N) model. Although sublytic C5b-9 assembly on the GMC membrane can trigger cell proliferation, the mechanisms are still undefined. We found that sublytic C5b-9-induced rat GMC proliferation was driven by extracellular signal‐regulated kinase 1/2 (ERK1/2), sry-related HMG-box 9 (SOX9), and Cyclin D1. Here, ERK1/2 phosphorylation was a result of the calcium influx-PKC-α-Raf-MEK1/2 axis activated by sublytic C5b-9, and Cyclin D1 gene transcription was enhanced by ERK1/2-dependent SOX9 binding to the Cyclin D1 promoter (−582 to −238 nt). In addition, ERK1/2 not only interacted with SOX9 in the cell nucleus to mediate its phosphorylation at serine residues 64 (a new site identified by mass spectrometry) and 181 (a known site), but also indirectly induced SOX9 acetylation by elevating the expression of general control non-repressed protein 5 (GCN5), which together resulted in Cyclin D1 synthesis and GMC proliferation. Moreover, our in vivo experiments confirmed that silencing these genes ameliorated the lesions of Thy‐1N rats and reduced SOX9 phosphorylation, acetylation and Cyclin D1 expression. Furthermore, the renal tissue sections of MsPGN patients also showed higher phosphorylation or expression of ERK1/2, SOX9, and Cyclin D1. In summary, these findings suggest that sublytic C5b-9-induced GMC proliferation in rat Thy-1N requires SOX9 phosphorylation and acetylation via enhanced Cyclin D1 gene transcription, which may provide a new insight into human MsPGN pathogenesis.
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Yanyan Ren,Hongfeng Li,Guanglei Wu,Le Yang,Chenhui Zheng,LIUDING WANG,Fang Ren,Hui Xing,HONGJING WU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.2
Al/Fe/Co doped ordered mesoporous carbon (OMC) composites have been synthesized by a facile method, and the influence of dopant on the electromagnetic (EM) and microwave absorption properties was investigated in the frequency range of 2–18 GHz. Compared with Fe/Co– OMC composites, the Al–OMC nanocomposite played a great role in adjusting values and frequency dependence of complex permittivity, which gives rise to significant improved microwave absorption and reduced thickness of the corresponding paraffin wax composites. Reflection loss (RL) values less than -5 dB and -10 dB were obtained in the frequency range of 9.2–18 GHz and 10.7–14.7 GHz with a single thickness of 2.00 mm, respectively. Such enhanced EM wave absorption property of the Al–OMC/paraffin wax composite was ascribed to its superior impedance matching characteristic. Thin thickness, broadband absorption microwave absorbers with Al doped OMC nanocomposites were obtained.
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Parametric studies of lubrication performance of a helical gear pair with non-Newtonian fluids
Mingyong Liu,Caichao Zhu,Hua iju Liu,Chenhui Wu 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.1
In this paper, Thermal elastohydrodynamic lubrication (TEHL) model of a helical gear pair is proposed to study contact performanceduring the whole meshing period. Effects of working conditions and design parameters on lubrication performance, i.e. film thickness,pressure, temperature, friction coefficient, etc. are investigated. Influence of thermal effect and non-Newtonian effect are evaluatedthrough a detailed study on three characteristic meshing positions. Results show that, the thermal effects and non-Newtonian fluid bothhave significant effects on the lubrication performance of the helical gear pair, especially in high speed, heavy load cases. The effects ofnormal pressure angle, helix angle and module on lubrication performance along the line of action are discussed.
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