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        Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma

        Wei Wang,Chaojie Wei,Zhenshun Cheng,Jiong Yang 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.6

        Purpose: Allergen exposure induces aberrant T helper (Th) 2 immune responses in patients with allergic asthma, but not in sensitized asymptomatic and nonallergic subjects. Interleukin (IL)-35-induced regulatory T (iTr35) cells are a new subset of regulatory T cells with immunoregulatory properties. These cells can significantly suppress Th2 responses in seasonal allergic rhinitis. However, it remains unknown whether iTr35 cells are involved in the immunoregulation of allergic asthmatic individuals after specific allergen exposure. Methods: The iTr35 cell frequency in peripheral blood mononuclear cells (PBMCs) was measured in patients with allergic asthma as well as in asymptomatic and healthy subjects. The difference in naïve CD4+ T cell conversion to iTr35 cells in vitro during allergen stimulation was also investigated. The effects of iTr35 cells on naïve CD4+ T cell differentiation into Th2 cells, CD4+CD25− T (Teff) cell proliferation and Th2 cytokine production in vitro were assessed. Results: Significantly reduced iTr35 cell frequencies and IL-35 expression levels were found in asthmatic patients with Derp1 allergy compared with asymptomatic and healthy subjects. Moreover, the circulating iTr35 cell proportion and IL-35 expression level in asthmatic patients gradually decreased with disease severity. Patients with allergic asthma had reduced transformation of naïve CD4+ T cells into iTr35 cells and IL-35 production after allergen exposure compared with asymptomatic and healthy subjects. Most importantly, iTr35 cells inhibited allergen-driven differentiation of naïve CD4+ T cells into Th2 cells, Teff cell proliferation and Th2 cytokine production in an IL-35-dependent manner. Conclusions: The results of our study suggest that iTr35 cells may play an important role in preventing Th2 responses to allergens by secreting IL-35 and that iTr35 cells may be a potential new immune regulator of allergic asthma.

      • SCOPUSKCI등재
      • KCI등재

        Fast Switching Direct Torque Control Using a Single DC-link Current Sensor

        Wei Wang,Ming Cheng,Zheng Wang,Bangfu Zhang 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.6

        This paper presents a fast switching direct torque control (FS-DTC) using only a single DC-link current sensor. In FS-DTC, six new active voltage complex space vectors (CSVs) are synthesized by the conventional active voltage space vectors (SVs). The corresponding sectors are rotated in the anticlockwise direction by 30 degrees. A selection table is defined to select the CSVs. Based on the “Different Phase Mode”, the output sequence of the selected CSV is optimized. Accordingly, a reconstruction method is proposed to acquire the phase currents. The core of the FS-DTC is that all of the three phase currents can be reliably reconstructed during every two sampling periods, which is the result of the fast switching between different phases. The errors between the reconstructed and actual currents are strictly limited in one sampling period. The FS-DTC has the advantages of the standard DTC scheme such as simple structure, quick torque response and robustness. As can be seen in the analysis, the FS-DTC can be thought of as an equivalent standard DTC scheme with 86.6% of the maximum speed, 173.2% of the torque ripple, and 115% of the response time of the torque. Based on a dSPACE DS1103 controller, the FS-DTC is implemented in an induction machine drive system. The results verify the effectiveness of the FS-DTC.

      • KCI등재

        Field Emission from TiO2/Ti Nanotube Array Films Modified with Carbon Nanotubes

        Cheng-Wei Wang,Rui-Sheng Guo,Jian-Biao Chen,Yan Li,Jian Wang,Wei-Min Liu 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.6

        Well-aligned TiO2/Ti nanotube array films were synthesized by using anodic oxidation of titanium in 0.5-wt% HF and were modified with carbon nanotubes (CNTs) assembled by using catalyzed chemical vapor deposition (CVD) at 650 ˚C. The morphology and the quality of the films were assessed with field emission scanning electron microscopy and Raman spectrometry (325 nm). The field emission characteristics of such TiO2/Ti nanostructures were investigated before and after being modified with CNTs. The results show that the TiO2/Ti nanotube arrays possess a moderate turn-on electric field of 7.4 V/µm, a field emission current density of 2.7 mA/cm2 at 23 V/µm. It is noteworthy that the turn-on field of the TiO2/Ti nanotube arrays modified with CNTs is decreased significantly to 1.3 V/µm, and the emission current density is increased to 10 mA/cm2 at 5.6 V/µm. This novel structure shows high emission efficiency as a field emitter. Well-aligned TiO2/Ti nanotube array films were synthesized by using anodic oxidation of titanium in 0.5-wt% HF and were modified with carbon nanotubes (CNTs) assembled by using catalyzed chemical vapor deposition (CVD) at 650 ˚C. The morphology and the quality of the films were assessed with field emission scanning electron microscopy and Raman spectrometry (325 nm). The field emission characteristics of such TiO2/Ti nanostructures were investigated before and after being modified with CNTs. The results show that the TiO2/Ti nanotube arrays possess a moderate turn-on electric field of 7.4 V/µm, a field emission current density of 2.7 mA/cm2 at 23 V/µm. It is noteworthy that the turn-on field of the TiO2/Ti nanotube arrays modified with CNTs is decreased significantly to 1.3 V/µm, and the emission current density is increased to 10 mA/cm2 at 5.6 V/µm. This novel structure shows high emission efficiency as a field emitter.

      • The genome of the mesopolyploid crop species Brassica rapa

        Wang, Xiaowu,Wang, Hanzhong,Wang, Jun,Sun, Rifei,Wu, Jian,Liu, Shengyi,Bai, Yinqi,Mun, Jeong-Hwan,Bancroft, Ian,Cheng, Feng,Huang, Sanwen,Li, Xixiang,Hua, Wei,Wang, Junyi,Wang, Xiyin,Freeling, Michael Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.10

        We report the annotation and analysis of the draft genome sequence of Brassica rapa accession Chiifu-401-42, a Chinese cabbage. We modeled 41,174 protein coding genes in the B. rapa genome, which has undergone genome triplication. We used Arabidopsis thaliana as an outgroup for investigating the consequences of genome triplication, such as structural and functional evolution. The extent of gene loss (fractionation) among triplicated genome segments varies, with one of the three copies consistently retaining a disproportionately large fraction of the genes expected to have been present in its ancestor. Variation in the number of members of gene families present in the genome may contribute to the remarkable morphological plasticity of Brassica species. The B. rapa genome sequence provides an important resource for studying the evolution of polyploid genomes and underpins the genetic improvement of Brassica oil and vegetable crops.

      • Short-Term Forecasting for Harbor Waterway Currents Speeds

        Cheng Gong,Yan Lv,Chunjiang Zhang,Xiyuan Wang,Wei Huangfu,Zhongshan Zhang 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12

        The ocean currents speeds in the harbor waterway are directly related to the ability of the ship to in or out the harbor. Accurately predict the speeds can assist the ship to choose the right time for sailing. To solve this problem, we chose two models of linear and non-linear prediction. We had set sensors in Qinhuangdao for a long time, then using the collected data for training. Our test is using a lot of random data to train and predict with different steps and orders. The results show that both methods can use less original data to train the model, and finally achieve preferably prediction. According to the characteristics of Qinhuangdao harbor, Auto-Regressive (AR) model is more appropriate than Support Vector Regression (SVR) model.

      • Low-Cost SVM-DTC Strategy of Induction Machine Drives Using Single DC-link Current Sensor

        Wang, Wei,Cheng, Ming,Hua, Wei,Ding, Shichuan,Zhu, Ying,Zhao, Wenxiang Journal of International Conference on Electrical 2012 Journal of international Conference on Electrical Vol.1 No.3

        In conventional direct torque control (DTC) using space-vector modulation (SVM) of induction machine (IM) drives, at least three current sensors are needed. In this paper, a low-cost SVM-DTC strategy is proposed, in which only a single current sensor is used. The position of the voltage space vector is divided into two areas: effective and non-effective area. If it is located in the non-effective area, the voltage space vector will be shifted into the effective area with minimum distortion. Further, the switching frequency remains constant. The simulation is carried out on a MATLAB/Simulink platform and the simulated results verify the effectiveness of the proposed strategy.

      • SCIESCOPUSKCI등재

        Fast Switching Direct Torque Control Using a Single DC-link Current Sensor

        Wang, Wei,Cheng, Ming,Wang, Zheng,Zhang, Bangfu The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.6

        This paper presents a fast switching direct torque control (FS-DTC) using only a single DC-link current sensor. In FS-DTC, six new active voltage complex space vectors (CSVs) are synthesized by the conventional active voltage space vectors (SVs). The corresponding sectors are rotated in the anticlockwise direction by 30 degrees. A selection table is defined to select the CSVs. Based on the "Different Phase Mode", the output sequence of the selected CSV is optimized. Accordingly, a reconstruction method is proposed to acquire the phase currents. The core of the FS-DTC is that all of the three phase currents can be reliably reconstructed during every two sampling periods, which is the result of the fast switching between different phases. The errors between the reconstructed and actual currents are strictly limited in one sampling period. The FS-DTC has the advantages of the standard DTC scheme such as simple structure, quick torque response and robustness. As can be seen in the analysis, the FS-DTC can be thought of as an equivalent standard DTC scheme with 86.6% of the maximum speed, 173.2% of the torque ripple, and 115% of the response time of the torque. Based on a dSPACE DS1103 controller, the FS-DTC is implemented in an induction machine drive system. The results verify the effectiveness of the FS-DTC.

      • KCI등재

        "Chindia" or Rivalry? Rising China, Rising India, and Contending Perspectives on India-China Relations

        ( Wei Cheng Wang ) 경남대학교 극동문제연구소 2011 ASIAN PERSPECTIVE Vol.35 No.3

        Whether and how India and China manage their futures as rising powers will critically shape international relations in the twenty-first century. These two countries demonstrate sharp contrasts in terms of their political systems, economic models, and social structures, despite their common aspirations for greater stature on the world stage. They have also maintained a very complex relationship that is weighed down by history but also offers promising opportunities in an era of globalization. While the implications for the rise of China have been widely debated, scant scholarly attention has been devoted to the rise of India or to how these two Asian great powers perceive each other`s ascendancy. This article examines the key factors influencing India-China relations, including territorial disputes, mutual threat perception and alignment patterns, and economic partnership and competition. It categorizes Indian elites` perspectives on the rise of China in three paradigms: geopolitical, geoeconomic, and geocivilizational. It ends with a discussion of the possible scenarios of future India-China relations.

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