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Comparative Analysis on Antioxidative Ability of Muscle between Laiwu Pig and Large White
Chen, Wei,Zhu, Hong-Lei,Shi, Yuan,Zhao, Meng-Meng,Wang, Hui,Zeng, Yong-Qing Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.8
This study was conducted to evaluate effects of storage temperatures ($4^{\circ}C$ and $20^{\circ}C$) and pig breeds (Laiwu pig and Large White pig) on the main antioxidative enzymes (superoxide dismutase, catalase, and glutathione peroxidase) activity and lipid oxidation in porcine Longissimus dorsi muscle. Activities of antioxidative enzymes (AOE) decreased slightly during storage, regardless of storage temperatures. Muscle antioxidative enzymes activities stored at $4^{\circ}C$ were higher than that stored at $20^{\circ}C$. Laiwu pig's enzymes activities were significantly (p<0.01) higher than Large White's. The level of malondialdehyde is a direct expression of the grade of lipid oxidation in meat. In our study, the malondialdehyde contents increased after 6 days storage. However, malondialdehyde contents of Laiwu pig were significantly (p<0.01) lower than Large White's. A lower content of malondialdehyde corresponds to a lower oxidation of lipids. These results indicated the muscle antioxidative ability of Laiwu pig was higher than Large White pig. It also implied that antioxidative enzymes were involved in the essentials and deciding mechanisms of meat quality by quenching oxygen free radicals and inhibiting lipid oxidation in muscle.
The role and mechanism of lncRNA NEAT1 in the fibrosis of pulmonary epithelial cell
Hui Xu,YanBo Chen,Jinqiang Zhuang,Shun Zhu,Bing Xu,Jiang Hong 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.2
Background Pulmonary fibrosis is a serious clinical fatal disease. Epithelial–mesenchymal transition (EMT) and lncRNA NEAT1 have been implied in its development and progression. Objective To study the role of lncRNA NEAT1 in the progression of fibrosis in human pulmonary epithelial cells (BEAS- 2B). Specifically, BEAS-2B was transfected with NEAT1 and miR-29c, EMT and cell proliferation were measured and the expression level of relevant genes was determined by Western blot. Result Results showed that NEAT1 promotes fibrosis and proliferation of BEAS-2B cells via the up-regulation of α-SMA, Vimentin, Snail and proliferation-related genes including Cyclin D1 and Cyclin E; miR-29c is a target gene of NEAT1 and through which NEAT1 regulates EMT and expression of proliferation-related genes. Conclusion This study investigated the mechanism of pulmonary fibrosis progression by elucidating the role of NEAT1/ miR-29c in the fibrosis and proliferation of BEAS-2B cells, thus providing a basis for the new therapeutic targets of pulmonary fibrosis.
Limonoids from the roots of Trichilia sinensis and their cytotoxicities
Zhu-Nian Wang,Wen-Li Mei,Hui-Qin Chen,Jun Wang,Zhu-Nian Wang,Hao Fu Dai 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.
Hui Chang,Yuhao Chen,Nan Zhang,Yan-Rong Zhu,Ting-Feng Yi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
FePO4 coated Li5Cr7Ti6O25 nanocomposites are synthesized according to a simple sol–gel method followingby a calcination procedure. XRD and Rietveld refinement result indicate that FePO4 decorating doesnot change the crystal structure and lattice parameters of Li5Cr7Ti6O25. SEM and TEM prove that the particlesize of all sample are evenly distributed in the 50–100 nm range. Both energy dispersion spectroscopymapping and HRTEM indicate the existence of FePO4 on the surface of Li5Cr7Ti6O25, whichprovides a good conductive contact. CV and EIS exhibit that FePO4 (3 wt%) coated Li5Cr7Ti6O25 materialhas lower polarization, larger Li+ diffusion coefficient and higher conductivity than other pureLi5Cr7Ti6O25 and other FePO4 coated Li5Cr7Ti6O25 composites. Therefore, FePO4 (3 wt%) coatedLi5Cr7Ti6O25 anode material displays the highest charge and discharge capacity at each rate. Theenhanced electrochemical performance of FePO4-coated Li5Cr7Ti6O25 result from the enhanced lithiumion and electron transfer kinetics. The pristine Li5Cr7Ti6O25 only shows a specific capacity of197 mAh g 1 at 500 mA g 1 after 100 cycles, but FePO4 (3 wt%)-coated Li5Cr7Ti6O25 achieves a highcapacity of 237.9 mAh g 1. Therefore, the FePO4 coating can be regarded as a promising strategy toimprove the electrochemical properties of Li5Cr7Ti6O25.
Dose-Dependent Associations between Wine Drinking and Breast Cancer Risk - Meta-Analysis Findings
Chen, Jia-Yan,Zhu, Hong-Cheng,Guo, Qing,Shu, Zheng,Bao, Xu-Hui,Sun, Feng,Qin, Qin,Yang, Xi,Zhang, Chi,Cheng, Hong-Yan,Sun, Xin-Chen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Purpose: To investigate any potential association between wine and breast cancer risk. Materials and Methods: We quantitatively assessed associations by conducting a meta-analysis based on evidence from observational studies. In May 2014, we performed electronic searches in PubMed, EmBase and the Cochrane Library to identify studies examining the effect of wine drinking on breast cancer incidence. The relative risk (RR) or odds ratio (OR) were used to measure any such association. Results: The analysis was further stratified by confounding factors that could influence the results. A total of twenty-six studies (eight case-control and eighteen cohort studies) involving 21,149 cases were included in our meta-analysis. Our study demonstrated that wine drinking was associated with breast cancer risk. A 36% increase in breast cancer risk was observed across overall studies based on the highest versus lowest model, with a combined RR of 1.0059 (95%CI 0.97-1.05) in dose-response analysis. However, 5 g/d ethanol from wine seemed to have protective value from our non-linear model. Conclusions: Our findings indicate that wine drinking is associated with breast cancer risk in a dose-dependent manner. High consumption of wine contributes to breast cancer risk with protection exerted by low doses. Further investigations are needed for clarification.
BiOCl/SnS2 Core-Shell Photocatalyst for the Degradation of Organic Pollutants
Hui Meng,Tingting Wang,Hongbin Chen,Yizhu Liu,Xiang Yu,Yi Zhu,Yuanming Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.8
BiOCl/SnS2 core-shell heterojunction is prepared by a facile and economic hydrothermal method. The obtained BiOCl/SnS2 heterojunction displays high photocatalytic activity in the degradation of Rhodamine B (RhB). The high performance is explained by the fast separation of the photoinduced electron–hole pairs promoted by the heterojunction. The cycle life of the heterojunction is also improved compared with individual BiOCl or SnS2.
Characterization of the Open Reading Frame 35 of Bombyx mori Nucleopolyhedrovirus
Zhu, Ying Min,Li, Guo Hui,Yao, Qin,Chen, Ke Ping,Guo, Zhong Jian Korean Society of Sericultural Science 2010 International Journal of Industrial Entomology Vol.21 No.2
Open reading frame 35 (bm35) of the Bombyx mori nucleopolyhedrovirus (BmNPV) is a special gene whose homologues are only found in some group-I nucleopolyhedroviruses, suggesting that bm35 plays a specific role in the viral life cycle. This paper described the characterization of BmNPV bm35. Computerassisted sequence analysis shows that a putative RING finger motif is observed in the protein, Bm35 encoded by bm35. The coding sequence of bm35 was amplified and subcloned into the vector pET30a(+) and the $(His)_6$-tagged fusion protein His-Bm35 was expressed in the Escherichia coli BL21 (DE3) LysS cells. The bm35 transcript and Bm35 protein were detected in BmNPV-infected BmN cells at 12~48 h post infection (p.i.) by RT-PCR and Western blot analysis using the polyclonal antibody generated by immunizing a rabbit with purified $(His)_6$-tagged Bm35, suggesting that bm35 is synthesized in the late stage of BmNPV infection cycle. Bm35 was not a structural component associated with budded virus (BV) and occlusion derived virus (ODV). These data indicated that bm35 is a functional gene in the BmNPV life cycle.
EFFECT OF MACROMOLECULAR COUPLING AGENT PMMA-b-PVTES ON STABILIZING NANO-Si3N4
HUI ZHU,Jiasheng Qian,Peng Chen,JIBIN MIAO,RU XIA,Bin Yang,LIFEN SU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8
Poly(methyl methacrylate)-b-poly(vinyltriethoxysilane) (PMMA-b-PVTES) are synthesized using atom transfer radical polymerization (ATRP) and used as macromolecular coupling agents to modify silicon nitride nanoparticles (nano-Si3N4). The chemical composition of copolymers PMMA-b-PVTES and modified nano-Si3N4 are confirmed by various characterization techniques. The modified nano-Si3N4 shows excellent hydrophobic nature, which make nanoparticles (NPs) stably disperse in organic solvent. Transmission electron microscope (TEM), particle size testing, contact angle measuring and sedimentation experiment are employed to examine the dispersion of modified nano-Si3N4 in chloroform. By comparing the effects of copolymers with varied number-average molecular weight (Mn) and block length ratio on stabilizing nano-Si3N4, we discussed the mechanism of macromolecular coupling agent stabilizing NPs. In our experiments, the copolymer PMMA88-b-PVTES17 is found to be the most effective macromolecular coupling agent for stabilizing nano-Si3N4.
Efficacy of Pap Test in Combination with ThinPrep Cytological Test in Screening for Cervical Cancer
Chen, Hua,Shu, Hui-Min,Chang, Zhou-Lin,Wang, Zhi-Feng,Yao, Hai-Hong,Zhu, Hong-Mei,Lu, Tian-Mei,Ma, Qiang-Yan,Yang, Bin-Lie Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Background: Our aim was to investigate the efficacy of the Pap test in combination with the ThinPrep cytological test (TCT) in screening for cervical cancer in China. Design: From March 2006 to October 2008, 988 women with the mean age $46.4{\pm}10.5$ years (range, 23-80 years) were recruited to receive cervical cancer screening. Pap test results ${\geq}$ grade III and TCT findings ${\geq}$ ASCUS/AGUS were considered abnormal. Subjects with a Pap test result ${\geq}$ grade IIb received TCT. Colposcopy and biopsies were performed in all participants, and final diagnosis was based on pathological findings. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and Youden index for predicting CIN I or above were determined. Results: The sensitivity, specificity, PPV, NPV and Youden index of the Pap test were 43.1%, 97.2%, 70.0%, 91.9%, and 40.3%, respectively. The same values for TCT in predicting CIN were 80.0%, 63.2%, 16.0%, 97.3%, and 43.2%, respectively. The two tests in combination gave values for predicting CIN of 64.8%, 87.6%, 43.6%, 94.4%, and 53.5%, respectively. Combined testing exhibited the highest Youden index (53.4%). Conclusion: The Pap test with a reduced threshold in combination with the TCT has high sensitivity and high specificity in screening for cervical cancer.