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- 저자 : Chen Xinguo (검색결과 4 건)
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Anti-glioma Effect and Safety of Docetaxel-loaded Nanoemulsion
Huil Gaoe,Xinguo Jiang,Zhiqing Pang,Shuaiqi Pan,Shijie Cao,Zhi Yang,Chen Chen 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2
Docetaxel, an inhibitor of microtubule depolymerization, has been used for many malignancies. Due to its toxicity and the non-selective distribution of its commercial formulation, Taxotere®, new formulations with less toxicity and tumor targeting need to be explored. For its safety and ease of factory scale production, nanoemulsion, was selected to encapsulate docetaxel. The particle size of docetaxel loaded nanoemulsion (DNE) was 72.3 nm, the average zeta potential was −6.38 mV, the encapsulation efficiency was 93.1% and the drug loading capacity was 2.87%. Although DNE presented similar antiproliferation effects on both U87 cells and bEnd.3 cells, its in vivo toxicity was significantly lower than Taxotere®. In vivo fluorescent imaging suggested nanoemulsions loaded with a fluorescent probe could distribute to the brain and accumulate at the glioma site. The pharmacological experiments also confirmed that the DNE could target glioma sites and prolong the median survival time of mice with gliomas. In conclusion, DNE is a new, less toxic, drug formulation that is effective for brain glioma therapy.
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Preparation and electrochemical performance of porous carbon derived from polypyrrole
Wu Lili,Chen Xinguo,Ding Chang,Wang Pitao,Luo Heming 한국탄소학회 2023 Carbon Letters Vol.33 No.2
Supercross-linked polymers are widely used as carbon precursor materials due to their abundant carbon sources and low cost. In this paper, a supercross-linked polymer was prepared by the solvothermal method. The supercross-linked polymer as a precursor and the PPyC-800-A was synthesized by activating this with KOH. The microstructure, structure, and electrochemical performances of porous carbon PPyC-800-A were studied at different of temperature and carbon alkali ratio. According to the results, the porous carbon PPyC-800-1:2 is mainly composed of a stack of spherical particles with a high surface area of 1427.03 m2 g−1, an average pore diameter of 2.32 nm, and a high specific capacitance of 217.7 F g−1 at a current density of 1.0 A g−1 in a 6 M KOH electrolyte. It’s retention rate is 97.58% after 5000 constant current charges and discharges. With a specific capacitance decay rate of 21.91 percent, an energy density of 11.96 Wh kg−1, and a power density of 500.0 W kg−1, the current density rises from 1.0 A g−1 to 10.0 A g−1, exhibiting remarkable electrochemical properties, cycling stability, and energy production performance This study contributes experimental ideas to the field of supercross-linked polymer-derived carbon materials and energy storage.
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Wu Lili,Wang Pitao,Chen Xinguo,Zhang Jianqiang,Luo Heming 한국탄소학회 2022 Carbon Letters Vol.32 No.3
Hypercrosslinked polymers HCPs have been widely used as precursors to prepare porous carbon materials because of their highly ordered porous structure and large specific surface area. In this paper, we used a solvothermal method to prepare a hypercrosslinked polymer, and the HCPC-700-A was prepared using an activation method with the hypercrosslinked polymer as the precursor. The effects of different carbon–alkali ratios on the microstructure, composition and electrochemical properties of porous carbon HCP were studied. The results show that the surface of porous carbon HCPC-700-A presents a relatively regular geometric shape, and a large number of pore structures are mainly micro- and mesopores. The specific surface area is 2074.53 m2 g−1, and the average pore size is between 1.29 and 1.93 nm. Porous carbon HCPC-700-1:2 has excellent electrochemical performance in 1 M H2SO4, and the specific capacitance is up to 464.4 F g−1 at a current density of 1 A g−1. The specific capacitance decay rate is 29.72% when the current density is increased from 1 A g−1 to 8 A g−1. After 5000 cycles, the capacitance retention rate is 91.16% at a current density of 2 A g−1, showing excellent electrochemical performance, good cycle stability and perfect energy storage performance. This research provides new experimental ideas for HCPs in the electrochemical energy storage field.
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The Method of Aiming towards the Normal Direction for Robotic Drilling
Yuhao Gao,Dan Wu,Yunfei Dong,Xinguo Ma,Ken Chen 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.6
During the robotic drilling of an aircraft assembly, the normal directions of the workpieces are to be measured to guide the robot by aiming the spindle at the real normal directions of the curved surfaces. This paper describes the development of a method of using four laser displacement sensors to measure the normal direction and the implementation of the proposed method in a robotic drilling system to meet industrial application requirements. First, a novel mechanical structure is introduced to achieve a higher installation accuracy for the laser displacement sensors with a micro adjusting method. Next, the hardware structures and a convenient method of calibrating the sensors are introduced. To accommodate the complexity of the industrial circumstance, a procedure of measuring and adjusting is developed with consideration of both an angular deviation threshold and a limited adjusting iteration. Finally, the experiments of measuring and adjusting iteratively show that two iterations can achieve a satisfactory angular deviation of 0.1° for planar workpieces and three iterations are required for curved workpieces, with the perpendicularity errors of the drilled holes being less than 0.3°. The results can meet the required perpendicularity accuracy of 0.5°.
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