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Effects of Perimeter to Core Connectivity on Tall Building Behavior
Besjak, Charles,Biswas, Preetam,Petrov, Georgi I.,Streeter, Matthew,Devin, Austin Council on Tall Building and Urban Habitat Korea 2017 International journal of high-rise buildings Vol.6 No.1
The Pertamina Energy Tower (PET) and Manhattan West North Tower (MWNT) are two supertall towers recently designed and engineered by Skidmore, Owings & Merrill (SOM). The structural system for both buildings consists of an interior reinforced concrete core and a perimeter moment frame system, which is primarily structural steel. As is typical for tall towers with both concrete and steel elements, staged construction analysis was performed in order to account for the long term effects of creep and shrinkage, which result in differential shortening between the interior concrete core and steel perimeter frame. The particular design of each tower represents two extremes of behavior; PET has a robust connection between the perimeter and core in the form of three sets of outriggers, while the perimeter columns of MWNT do not reach the ground, but are transferred to the core above the base. This paper will present a comparison of the techniques used during the analysis and construction stages of the design process with the goal of understanding the differences in structural behavior of these two building systems in response to the long term effects of creep and shrinkage. This paper will also discuss the design and construction techniques implemented in order to minimize the differential shortening between the interior and exterior over the lifespan of these towers.
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
Greenblatt, Matthew B.,Park, Kwang Hwan,Oh, Hwanhee,Kim, Jung-Min,Shin, Dong Yeon,Lee, Jae Myun,Lee, Jin Woo,Singh, Anju,Lee, Ki-young,Hu, Dorothy,Xiao, Changchun,Charles, Julia F.,Penninger, Josef M. The Rockefeller University Press 2015 The Journal of experimental medicine Vol.212 No.8
<▼1><P>Greenblatt et al. show that deletion of CHMP5 in osteoclasts leads to increased bone resorption coupled with exuberant osteoblast activity, resembling an early onset form of human Paget’s Disease of Bone</P></▼1><▼2><P>Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we demonstrate that modulation of NF-κB signaling in osteoclasts via a novel activity of charged multivesicular body protein 5 (CHMP5) is a key determinant of systemic rates of bone turnover. A conditional deletion of CHMP5 in osteoclasts leads to increased bone resorption by osteoclasts coupled with exuberant bone formation by osteoblasts, resembling an early onset, polyostotic form of human Paget’s disease of bone (PDB). These phenotypes are reversed by haploinsufficiency for <I>Rank</I>, as well as by antiresorptive treatments, including alendronate, zolendronate, and OPG-Fc. Accordingly, CHMP5-deficient osteoclasts display increased RANKL-induced NF-κB activation and osteoclast differentiation. Biochemical analysis demonstrated that CHMP5 cooperates with the PDB genetic risk factor valosin-containing protein (VCP/p97) to stabilize the inhibitor of NF-κBα (IκBα), down-regulating ubiquitination of IκBα via the deubiquitinating enzyme USP15. Thus, CHMP5 tunes NF-κB signaling downstream of RANK in osteoclasts to dampen osteoclast differentiation, osteoblast coupling and bone turnover rates, and disruption of CHMP5 activity results in a PDB-like skeletal disorder.</P></▼2>
Ryan Matthew Cox,Tyler James Brolin,Eric Michael Padegimas,Mark David Lazarus,Charles Lonnie Getz,Matthew Lee Ramsey,Gerald Ross Williams,Joseph Albert Abboud 대한정형외과학회 2019 Clinics in Orthopedic Surgery Vol.11 No.3
Background: The purpose of this study was to compare outcomes of patients who underwent bilateral total shoulder arthroplasties (TSAs) for osteoarthritis (OA) versus bilateral reverse shoulder arthroplasties (RSAs) for cuff tear arthropathy (CTA). Methods: Inclusion criteria were patients who underwent bilateral TSAs for OA or bilateral RSAs for CTA with at least 2 years of follow-up. Twenty-six TSA patients (52 shoulders) were matched 2 to 1 with 13 RSA patients (26 shoulders) by sex, age at first surgery, and time between surgeries. Outcomes measured were shoulder range of motion (ROM), complications, and patient-reported scores. Results: Preoperatively, TSA patients had significantly better forward elevation (FE) of both shoulders than RSA patients (dominant side [Dom]: 103° ± 32° vs. 81° ± 31°, p = 0.047; nondominant side [non-Dom]: 111° ± 28° vs. 70° ± 42°, p = 0.005) without significant differences in external (ER) or internal rotation (IR). Postoperatively, TSA patients had significantly better FE (Dom and non-Dom: 156° ± 12°, 156° ± 14° vs. 134° ± 24°, 137° ± 23°; p = 0.006, p = 0.019) and ER (42° ± 11°, 43° ± 10° vs. 24° ± 12°, 25° ± 10°; p < 0.001, p < 0.001) bilaterally and IR of their dominant arm (L1 vs. L4, p = 0.045). TSA patients had significantly better activities of daily living external and internal rotations (ADLEIR) scores (Dom and non-Dom: 35.3 ± 1.0, 35.5 ± 0.9 vs. 32.1 ± 2.4, 32.5 ± 2.2; p = 0.001, p = 0.001), American Shoulder and Elbow Surgeons scores (94.2 ± 8.4, 94.2 ± 8.2 vs. 84.7 ± 10.0, 84.5 ± 8.0; p = 0.015, p = 0.004), and Single Assessment Numerical Evaluation (SANE) scores (93.5 ± 7.6, 93.8 ± 11.8 vs. 80.5 ± 14.2, 82.3 ± 13.1; p = 0.014, p = 0.025), with no significant difference in visual analog scale pain scores (0.4 ± 1.0, 0.3 ± 1.0 vs. 0.7 ± 1.3, 0.8 ± 1.2) bilaterally. Conclusions: Overall, patients with bilateral TSAs and RSAs exhibited improved ROM and patient-reported outcomes. Those with bilateral TSAs had better functional outcomes than those with bilateral RSAs.
Borondifluoride complexes of hemicurcuminoids as bio-inspired push–pull dyes for bioimaging
Kim, Eunsun,Felouat, Abdellah,Zaborova, Elena,Ribierre, Jean-Charles,Wu, Jeong Weon,Senatore, Sé,bastien,Matthews, Cé,dric,Lenne, Pierre-Franç,ois,Baffert, Carole,Karapetyan, Artak,G The Royal Society of Chemistry 2016 Organic & Biomolecular Chemistry Vol.14 No.4
<P>Hemicurcuminoids are based on half of the pi-conjugated backbone of curcuminoids. The synthesis of a series of such systems and their borondifluoride complexes is described. The electrochemical and photophysical properties of difluorodioxaborine species were investigated as a function of the nature of electron donor and acceptor groups appended at either terminal positions of the molecular backbone. The emissive character of these dipolar dyes was attributed to an intraligand charge transfer process, leading to fluorescence emission that is strongly dependent on solvent polarity. Quasi-quantitative quenching of fluorescence in high polarity solvents was attributed to photoinduced electron transfer. These dyes were shown to behave as versatile fluorophores. Indeed, they display efficient two-photon excited fluorescence emission leading to high two-photon brightness values. Furthermore, they form nanoparticles in water whose fluorescence emission quantum yield is less than that of the dye in solution, owing to aggregation-induced fluorescence quenching. When cos7 living cells were exposed to these weakly-emitting nanoparticles, one-and two-photon excited fluorescence spectra showed a strong emission within the cytoplasm that originated from the individual molecules. Dye uptake thus involved a disaggregation mechanism at the cell membrane which restored fluorescence emission. This off-on fluorescence switching allows a selective optical monitoring of those molecules that do enter the cell, which offers improved sensitivity and selectivity of detection for bioimaging purposes.</P>