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Wang, Chao,Xiao, Qian,Li, Yu-Wen,Zhao, Chao,Jia, Na,Li, Rui-Li,Cao, Shan-Shan,Cui, Jia,Wang, Lu,Wu, Yin,Wen, Ai-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.
Some completely monotonic functions involving the gamma and polygamma functions
Ai-Jun Li,Chao-Ping Chen 대한수학회 2008 대한수학회지 Vol.45 No.1
In this paper, some logarithmically completely monotonic, strongly completely monotonic and completely monotonic functions related to the gamma, digamma and polygamma functions are established. Several inequalities, whose bounds are best possible, are obtained. In this paper, some logarithmically completely monotonic, strongly completely monotonic and completely monotonic functions related to the gamma, digamma and polygamma functions are established. Several inequalities, whose bounds are best possible, are obtained.
Luo, Ai-Ping,Luo, Zhi-Chao,Xu, Wen-Cheng,Cui, Hu The Optical Society 2010 Optics express Vol.18 No.6
<P>A wavelength switchable all-fiber comb filter with flat-top spectral response based on a double-loop Mach-Zehnder (M-Z) interferometer is proposed and demonstrated. The proposed flat-top filter consists of a rotatable polarizer and a double-loop M-Z interferometer composed of two fiber couplers with a polarization controller (PC) in the first loop. In the theoretical analysis, when the second coupler of the M-Z interferometer is a non-3dB one, with proper settings of the polarization state of the input light and the PC, the wavelength switchable comb filter with flat-top passband can be obtained. Theoretical prediction was verified by experimental demonstration. The measured 1 dB bandwidth was 0.51 nm with a channel spacing of 0.98 nm, indicating that the flat-top passband of 1 dB bandwidth extends to about 50% of the comb spacing.</P>
Yan-chao Wang,Jin-miao Lu,Hui-zi Jin,Ai-niu Ma,Jin-yang Zhang,Nian Gong,Qi Xiao,Bin Zhu,Ying-fang Lv,Na Yu,Wei-dong Zhang,Yong-xiang Wang 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.2
BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (SamdasooTM), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.
SOME COMPLETELY MONOTONIC FUNCTIONS INVOLVING THE GAMMA AND POLYGAMMA FUNCTIONS
Li, Ai-Jun,Chen, Chao-Ping Korean Mathematical Society 2008 대한수학회지 Vol.45 No.1
In this paper, some logarithmically completely monotonic, strongly completely monotonic and completely monotonic functions related to the gamma, digamma and polygamma functions are established. Several inequalities, whose bounds are best possible, are obtained.
Zubin Ai,Hangjun Liu,Jiaguo Zhang,Chao Zhang,Cong Wang,Zuqian Jiang,Ru-Cheng Xiao 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11
This paper introduces the mechanical and economic performance of cable-stayed bridges with ultra-high-performance concrete (UHPC) girders. Based on the determined general layout and structure system, aiming at minimizing material consumption and considering multiple constraints, the parametric analysis and optimization process of the UHPC girder were discussed. Subsequently, full-scale models of a 1,200 m cable-stayed bridge with UHPC girders and those with steel girders were established and analyzed under load combinations to evaluate their static mechanical performance. Additionally, the material consumption estimation equation was established to evaluate the economic performance of cable-stayed bridges. The economic performance of cable-stayed bridges with UHPC-girder scheme and that of steel-girder scheme were investigated and compared by theoretical calculation and finite element modelling. The results indicated that UHPC-girder cable-stayed bridges are highly competitive for super long-span cable-stayed bridges and represent a promising alternative for the design of large-span bridges in the future. This study provides valuable insights into the feasibility and potential of UHPC-girder cable-stayed bridges.
An Efficient Broadcast Technique for Vehicular Networks
Ho, Ai Hua,Ho, Yao H.,Hua, Kien A.,Villafane, Roy,Chao, Han-Chieh Korea Information Processing Society 2011 Journal of information processing systems Vol.7 No.2
Vehicular networks are a promising application of mobile ad hoc networks. In this paper, we introduce an efficient broadcast technique, called CB-S (Cell Broadcast for Streets), for vehicular networks with occlusions such as skyscrapers. In this environment, the road network is fragmented into cells such that nodes in a cell can communicate with any node within a two cell distance. Each mobile node is equipped with a GPS (Global Positioning System) unit and a map of the cells. The cell map has information about the cells including their identifier and the coordinates of the upper-right and lower-left corner of each cell. CB-S has the following desirable property. Broadcast of a message is performed by rebroadcasting the message from every other cell in the terrain. This characteristic allows CB-S to achieve an efficient performance. Our simulation results indicate that messages always reach all nodes in the wireless network. This perfect coverage is achieved with minimal overhead. That is, CB-S uses a low number of nodes to disseminate the data packets as quickly as probabilistically possible. This efficiency gives it the advantage of low delay. To show these benefits, we give simulations results to compare CB-S with four other broadcast techniques. In practice, CB-S can be used for information dissemination, or to reduce the high cost of destination discovery in routing protocols. By also specify the radius of affected zone, CB-S is also more efficient when broadcast to a subset of the nodes is desirable.
Association of Urinary Cesium with Breast Cancer Risk
Qin, Ya-Chao,Tang, Lu-Ying,Su, Yi,Chen, Li-Juan,Su, Feng-Xi,Lin, Ying,Zhang, Ai-Hua,Ren, Ze-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: The aim of this study is to examine the association of urinary cesium with breast cancer risk. Materials and Methods: We collected survey data and urine specimens from 240 women with incident invasive breast cancer before their treatment and 246 age-matched female controls between October 2009 and July 2010. Urinary concentrations of cesium were determined by inductively coupled plasma mass spectrometry. Interviews were conducted by face-to-face to obtain information on potential breast cancer risk factors. Logistic regression analysis was used to estimate the associations. Results: Creatinine-adjusted levels [median ($25^{th}$, $75^{th}$) ug/g] of cesium in cases and controls were 17.6 (13.1, 24.0) and 19.3 (15.3, 25.7), respectively. After adjustment for potential risk factors, women in the second and highest tertile of cesium showed a decreased risk of breast cancer in a dose-dependent manner as compared with those in the lowest tertile [ORs and 95% CIs: 0.75 (0.46-1.22) and 0.50 (0.30-0.82), respectively]. This decrease was more evident in women with ER positive or localized clinical stage in an exploratory stratification analysis. Conclusions: These findings suggest that cesium may have anticancer efficacy and urinary cesium has potential as a biomarker for breast cancer risk assessment.