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Regulating exocytosis of nanoparticles <i>via</i> host–guest chemistry
Kim, Chaekyu,Tonga, Gulen Yesilbag,Yan, Bo,Kim, Chang Soo,Kim, Sung Tae,Park, Myoung-Hwan,Zhu, Zhengjiang,Duncan, Bradley,Creran, Brian,Rotello, Vincent M. The Royal Society of Chemistry 2015 Organic & Biomolecular Chemistry Vol.13 No.8
<P>Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis of the nanoparticles is a key factor in the fabrication of effective nanocarriers for chemotherapeutic treatments but orthogonal control of exocytosis in the cellular environment is a major challenge. Herein, we present the first example of regulating exocytosis of gold nanoparticles (AuNPs), a model drug carrier, by using a simple host–guest supramolecular system. AuNPs featuring quaternary amine head groups were internalized into the cells through endocytosis. Subsequent <I>in situ</I> treatment of a complementary cucurbit[7]uril (CB[7]) to the amine head groups resulted in the AuNP-CB[7] complexation inside cells, rendering particle assembly. This complexation induced larger particle assemblies that remained sequestered in the endosomes, inhibiting exocytosis of the particles without any observed cytotoxicity.</P> <P>Graphic Abstract</P><P>Regulating exocytosis of AuNPs by using host–guest interactions between AuNPs and CB[7] molecules. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4ob02433h'> </P>
Intra-mitochondrial biomineralization for inducing apoptosis of cancer cells
Kim, Sangpil,Palanikumar, L.,Choi, Huyeon,Jeena, M. T.,Kim, Chaekyu,Ryu, Ja-Hyoung Royal Society of Chemistry 2018 Chemical Science Vol.9 No.9
<▼1><P>Mitochondria targeting mineralization can form biominerals inside cancerous mitochondria through concentration dependent silicification, resulting in dysfunction of mitochondria leading to apoptosis. These results suggest potential therapeutics for cancer treatment.</P></▼1><▼2><P>The use of biomineralization that regulates cellular functions has emerged as a potential therapeutic tool. However, the lack of selectivity still limits its therapeutic efficacy. Here, we report a subcellular-targeting biomineralization system featuring a triphenylphosphonium cation (TPP) (the mitochondria-targeting moiety) and trialkoxysilane (the biomineralization moiety <I>via</I> silicification). The TPP-containing trialkoxysilane exhibited approximately seven times greater cellular uptake into cancer cells (SCC7) than into normal cells (HEK293T) due to the more negative mitochondrial membrane potentials of the cancer cells. In turn, its accumulation inside mitochondria (pH 8) induces specific silicification, leading to the formation of silica particles in the mitochondrial matrix and further activation of apoptosis. <I>In vivo</I> assessment confirmed that the biomineralization system efficiently inhibits tumor growth in a mouse xenograft cancer model. Exploiting both the subcellular specificity and the targeting strategy provides new insight into the use of intracellular biomineralization for targeted cancer therapy.</P></▼2>
A highly efficient organic sensitizer for dye-sensitized solar cells
Hwang, Suyoung,Lee, Jung Ho,Park, Chanmoo,Lee, Hoinglae,Kim, Chaekyu,Park, Chiyoung,Lee, Mi-Hyeon,Lee, Wanin,Park, Jihee,Kim, Kyungkon,Park, Nam-Gyu,Kim, Chulhee Royal Society of Chemistry 2007 Chemical communications Vol.2007 No.46
<P>We have synthesized a highly efficient organic dye for a dye-sensitized solar cell; the overall solar-to-energy conversion efficiency was 9.1% at AM 1.5 illumination (100 mW cm<SUP>−2</SUP>): short-circuit current density (<I>J</I><SUB>sc</SUB>) = 18.1 mA cm<SUP>−2</SUP>, open circuit photovoltage (<I>V</I><SUB>oc</SUB>) = 743 mV and fill factor (ff) = 0.675.</P> <P>Graphic Abstract</P><P>A π-conjugated dye with donor–acceptor moieties exhibited high efficiency for a dye-sensitized solar cell. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b709859f'> </P>
Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles
Batakrishna Jana,김성찬,Huyeon Choi,Seongeon Jin,Kibeom Kim,Min Soo Kim,Hyojin Lee,Kwan Hyi Lee,Jungmin Lee,Myoung-Hwan Park,Youngdo Jeong,Ja-Hyoung Ryu,Chaekyu Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.81 No.-
Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct onepotsynthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostaticattraction between AuCl4-anions and positively charged ligands. This paper describes the one-potsynthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the hostmolecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively chargedguest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directlyadding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential inbiomedical applications is demonstrated by siRNA transfection experiments. This approach relying onsupramolecular-mediated interactions may provide new insights into organic/inorganic reactions thatinvolve electrostatic disturbance.
Home energy management system based on power line communication
Young-Sung Son,Pulkkinen, T,Kyeong-Deok Moon,Chaekyu Kim IEEE 2010 IEEE transactions on consumer electronics Vol.56 No.3
<P>This paper describes a home energy management system (HEMS) based on power line communication. Smart metering and power line communication can provide detailed information of energy consumption patterns and intelligent controlling to appliances at home. We propose a HEMS that can provide easy-to-access information on home energy consumption in real time, intelligent planning for controlling appliances, and optimization of power consumption at home. The HEMS consists of three modules: an advanced power control planning engine, a device control module, and a power resource management server. Our prototype system reduces the cost of power consumption by about 10%.</P>
Palanikumar, L.,Choi, Eun Seong,Oh, Jun Yong,Park, Soo Ah,Choi, Huyeon,Kim, Kibeom,Kim, Chaekyu,Ryu, Ja-Hyoung American Chemical Society 2018 Biomacromolecules Vol.19 No.7
<P>Current drug delivery systems are hampered by poor delivery to tumors, in part reflecting poor encapsulation stability of nanocarriers. Although nanocarriers such as polymeric micelles have high colloidal stability and do not aggregate or precipitate in bulk solution, nanocarriers with low encapsulation stability can lose their cargo during circulation in blood due to interactions with blood cells, cellular membranes, serum proteins, and other biomacromolecules. The resulting premature drug release from carriers limits the therapeutic efficacy at target sites. Herein, we report a simple and robust technique to improve encapsulation stability of drug delivery systems. Specifically, we show that installation of disulfide cross-linked noncovalent polymer gatekeepers onto mesoporous silica nanoparticles with a high loading capacity for hydrophobic drugs enhances <I>in vivo</I> therapeutic efficacy by preventing premature release of cargo. Subsequent release of drug cargos was triggered by cleavage of disulfide cross-linking by glutathione, leading to improved antitumor activity of doxoroubicin in mice. These findings provide novel insights into the development of nanocarriers with high encapsulation stability and improved <I>in vivo</I> therapeutic efficacy.</P> [FIG OMISSION]</BR>