http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Radwaste management aspects of the test blanket systems in ITER
van der Laan, J.G.,Canas, D.,Chaudhari, V.,Iseli, M.,Kawamura, Y.,Lee, D.W.,Petit, P.,Pitcher, C.S.,Torcy, D.,Ugolini, D.,Zhang, H. North-Holland ; Elsevier Science Ltd 2016 Fusion engineering and design Vol.109 No.1
Test Blanket Systems (TBS) will be operated in ITER in order to prepare the next steps towards fusion power generation. After the initial operation in H/He plasmas, the introduction of D and T in ITER will mark the transition to nuclear operation. The significant fusion neutron production will give rise to nuclear heating and tritium breeding in the in-vessel part of the TBS. The management of the activated and tritiated structures of the TBS from operation in ITER is described. The TBS specific features like tritium breeding and power conversion at elevated temperatures, and the use of novel materials require a dedicated approach, which could be different to that needed for the other ITER equipment.
Molecular Links between Mitochondrial Dysfunctions and Schizophrenia
Cana Park,박상기 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.2
Schizophrenia is a complex neuropsychiatric disorder with both neurochemical and neurodevelopmental com-ponents in the pathogenesis. Growing pieces of evidence indicate that schizophrenia has pathological components that can be attributable to the abnormalities of mitochondrial function, which is supported by the recent finding suggesting mitochondrial roles for Disrupted-in-Schizophrenia 1 (DISC1). In this minireview, we briefly summarize the current un-derstanding of the molecular links between mitochondrial dysfunctions and the pathogenesis of schizophrenia, covering recent findings from human genetics, functional genomics, proteomics, and molecular and cell biological approaches.
Cana Park,우은란,이동건 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.6
Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Can-dida albicans in an energy-independent manner. To char-acterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.
Park, Cana,Woo, Eun-Rhan,Lee, Dong-Gun Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.6
Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.
Lee, Juneyoung,Park, Cana,Park, Seong-Cheol,Woo, Eun-Rhan,Park, Yoonkyung,Hahm, Kyung-Soo,Lee, Dong Gun John Wiley Sons, Ltd. 2009 Journal of Peptide Science Vol.15 No.9
<P>Previously, we investigated the antimicrobial properties of pleurocidin (Ple) enantiomers. Our studies showed that the L-enantiomer exhibited about a 2–16 fold more potent activity against bacterial strains as compared to that of the D–enantiomer. However, fungal strains were about two–fold more susceptible to the D–enantiomer than to the L-enantiomer. In this study, confocal laser scanning microscopy indicates that the Ple enantiomers internalize into the cell surface. The present results also suggest that they could be characterized by a membrane–active mechanism. To further elucidate their selective membranolytic activities, we conducted a fluorescence analysis. A study with 1,6–diphenyl–1,3,5–hexatriene, a hydrophobic molecule, showed that the L–and the D–enantiomer exert more potent antibacterial or antifungal activity than their opposite enantiomer, respectively. Furthermore, we synthesized liposomes by using representative phospholipids consisting of bacterial or fungal membranes. Our results show that the L-enantiomer causes significant dye leakage from negatively charged liposomes (PG/CL; 58:42, PC/PG; 1:1, w/w) which mimic bacterial membranes such as Staphylococcus aureus. Conversely, the D–enantiomer has more potent leakage effects against fungal liposomes (PC/PE/PI/ergosterol; 5:4:1:2, w/w/w/w, PC/ergosterol; 10:1, w/w). In summary, these results suggest that the selective antimicrobial effects of the Ple enantiomers against bacterial and fungal cells may be due to the different lipid compositions of prokaryotes and eukaryotes. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.</P>
Eloy Ruiz,Ramiro Fernandez-Placencia,Jorge Bustamante,Jose Medina-Cana,Elmer Loja,Francisco Berrospi 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.4
Since the inception of the associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure, many centres have used this technique for patients who would otherwise be considered unresectable due to insufficient future liver remnant. In this report, we presented the case of a paediatric patient with recurrent hepatocellular carcinoma who underwent monosegment ALPPS (M-ALPPS) hepatectomy preserving segment 1 as the sole liver remnant using indocyanine green (ICG) as a fluorescence guide.
Disrupted-in-schizophrenia 1 (DISC1) Regulates Dysbindin Function by Enhancing Its Stability
Lee, Seol-Ae,Kim, Seong-Mo,Suh, Bo Kyoung,Sun, Hwa-Young,Park, Young-Un,Hong, Ji-Ho,Park, Cana,Nguyen, Minh Dang,Nagata, Koh-ichi,Yoo, Joo-Yeon,Park, Sang Ki American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.11
<P>Dysbindin and DISC1 are schizophrenia susceptibility factors playing roles in neuronal development. Here we show that the physical interaction between dysbindin and DISC1 is critical for the stability of dysbindin and for the process of neurite outgrowth. We found that DISC1 forms a complex with dysbindin and increases its stability in association with a reduction in ubiquitylation. Furthermore, knockdown of DISC1 or expression of a deletion mutant, DISC1 lacking amino acid residues 403–504 of DISC1 (DISC1<SUP>Δ403–504</SUP>), effectively decreased levels of endogenous dysbindin. Finally, the neurite outgrowth defect induced by knockdown of DISC1 was partially reversed by coexpression of dysbindin. Taken together, these results indicate that dysbindin and DISC1 form a physiologically functional complex that is essential for normal neurite outgrowth.</P>