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위령탕 및 인진오령산이 Galactosamine에 의한 白鼠의 肝損傷에 미치는 影響
郭燮,田炳勳,禹元洪,鄭遇悅 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1
The protective effects of Wuiryungtang(위령탕) and Inginoryungsan(인진오령산) on D-galactoasmine induced liver damage were researched in rats. Oral feeding or Wuiryungtang and Inginoryungsan to rat on four consecutive times at 0, 3, 6 and 12 hours after galactosamine(375mg/kg, ip) treatment effectively protect against AST, AST, ASP, LDH, and total and direct bilirubin changes induced by galactosamine. In particular, the effect of Wuiryungtang plus Inginoryungsan have shown the important significance on protecting the liver damage induced by galactosamine, and that has striding effects on the inhibition of serum bvilirubin level change. In this paper, however, if cannot be studied for Wuiryungtang and Inginoryungsan how to have these protective effects and the process. The more continuous research will show the process and mechanism of the effects. Then the prescriptions will be clinically used broadly on the liver.
李秀培,金德宗,金康柱,田炳勳,禹元洪 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1
The purpose of this study is to know the effects of Pinelliae Tuber on the cytotoxicity of human gingival fibroblasts according to brewing methods. Pinelliae Tuber was extracted by water in the state of being raw materials, prebrewing with Zingiberis Tuber and alumen. The extracted Pinelliae Tuber was applied to the cultured human gingival fibroblasts. The cytotoxic effct of Pinelliae Tuber was meaeured by MTTassay and microscopic findings. The results were as follows : 1. The cell viability of the fibroblasts by Pinelliae Tuber water extracts significantly decreased compared to control group. 2. The cell viability by the Pinelliae Tuber extracts prebrewed with Zingiberis Tuber was similiar to those of control group. 3. The cell viability by the Pinelliae Tuber extracts prebrewed with alumen slightly decreased, but was higher than those of PT group. 4. According to the microscopec findings, the number of cell count were smaller than normal in all experimental group, specially in the PT group, and showed the shrinkage of cytoplasmic process in the PT group and PA group.