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Aberrant expression of CD20 in thyroid cancer and its clinicopathologic significance
Bychkov, Andrey,Jung, Chan Kwon Elsevier 2018 Human pathology Vol.71 No.-
<P>CD20 is the first-line diagnostic marker of B-cells, which serves as the target of the therapeutic monoclonal antibodies in B-cell lymphomas and leukemias. Recently, aberrant CD20 expression has been described in a small series of papillary thyroid carcinomas (PTCs). We aimed to evaluate CD20 immunoexpression and to perform clinicopathologic correlation in a large set of thyroid tumors, including a cohort of high-grade thyroid cancer. A total of 625 cases of thyroid tumor comprised tissue microarrays of 538 PTCs and 47 follicular adenomas, and whole-slide sections of 40 aggressive thyroid carcinomas (10 radioiodine-refractory PTCs and 8 poorly differentiated, 5 anaplastic, and 17 medullary thyroid carcinomas) were immunostained with anti-CD20 monoclonal antibody. BRAF(V600E) mutation was tested by direct sequencing in 478 cancers. Our study found that a small subset of PTCs (<10%, mainly of classic variant) exhibited aberrant membranous expression of CD20. These tumors displayed less aggressive histological features and had a lower prevalence of BRAF(V600E) mutation. We also discovered that CD20 expression was maintained in 6%-20% of aggressive thyroid cancers but not observed in follicular adenomas. All CD20-positive tumor cells were negative for CD79a and PAX5. Aberrant expression of CD20 by thyroid cancer cells may present a diagnostic pitfall in cytologic evaluation of thyroid and cervical masses. Residual expression of CD20 in aggressive cancers may offer promise for translational implications, which merits further experimental investigation. (C) 2017 Elsevier Inc. All rights reserved.</P>
Bychkov, Igor V.,Kuzmin, Dmitry A.,Tolkachev, V.A.,Lee, Hyoung In,Shavrov, Vladimir G. Scientific.Net 2016 Materials Science Forum Vol. No.
<P>We have investigated theoretically the possibility of control of magnetic speckle-pattern rotation in gyrotropic optical fiber coated by conductive nanoshell. Investigation has been carried out for graphene and silver coated fibers. In graphene-coated fiber speckle-pattern rotation may be tuned by both magnetic field and chemical potential of graphene. It is shown that fiber coating by conductive nanoshell may leads to suppression of magnetic speckle-pattern rotation even for low-gyrotropic quartz fiber.</P>
Bychkov, Andrey,Jung, Chan Kwon,Liu, Zhiyan,Kakudo, Kennichi Springer US 2018 Endocrine pathology Vol.29 No.3
<P>The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was initiated and promoted by pathologists. Recent Asian studies added new knowledge to the existing literature to aid a better understanding of NIFTP. Our original data and the results of a meta-analysis suggest that the initial rate of NIFTP has been overestimated, averaging 9.1% (95% confidence interval [CI] 6.0–12.7%) of all papillary thyroid cancers worldwide. The incidence of NIFTP in the Asian population (1.6%, 95% CI 0.9–2.5%; 7 studies) is significantly lower than that reported in the non-Asian series (13.3%, 95% CI 9.0–18.3%; 18 studies). Such difference could be attributed to various perceptions of histological diagnostic thresholds, different nature of papillary thyroid carcinoma, and different approaches in the management of thyroid nodules. The active surveillance for indeterminate nodules and NIFTP, largely represented in the indeterminate cytologic categories, promoted by Japanese institutions establishes a new paradigm to reduce overtreatment of these patients. The lower prevalence of NIFTP in the Asian series indicates a low impact on the risk of malignancy in cytopathology, as it was demonstrated in our original multi-institutional cohort of thyroid nodules, and may predict a low impact on the performance of commercial molecular tests. Several Korean studies addressed the issue of <I>BRAF</I> mutation in NIFTP, which prompted the current refinement of the diagnostic criteria for NIFTP. Our survey of Asian pathologists found that the term NIFTP has not been universally adopted in the local practice. Endocrine pathologists must promote the new entity through provision of educational activities.</P>
What’s new in thyroid pathology 2024: updates from the new WHO classification and Bethesda system
Andrey Bychkov,정찬권 대한병리학회 2024 Journal of Pathology and Translational Medicine Vol.58 No.2
In line with the release of the 5th edition WHO Classification of Tumors of Endocrine Organs (2022) and the 3rd edition of the Bethesda System for Reporting Thyroid Cytopathology (2023), the field of thyroid pathology and cytopathology has witnessed key transformations. This digest brings to the fore the refined terminologies, newly introduced categories, and contentious methodological considerations pivotal to the updated classification.
정찬권,Andrey Bychkov,Kennichi Kakudo 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.5
The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.
Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms
정찬권,Andrey Bychkov,송동은,김장희,Yun Zhu,Zhiyan Liu,Somboon Keelawat,Chiung-Ru Lai,Mitsuyoshi Hirokawa,Kaori Kameyama,Kennichi Kakudo 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.1
Background: Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features morphologically and identify morphological features to differentiate thyroid tumors with RAS-like mutations from encapsulated papillary thyroid carcinoma (PTC) with predominant follicular growth and BRAFV600E mutation. Methods: Representative whole slide images of 16 encapsulated thyroid tumors with predominant follicular growth were reviewed by 12 thyroid pathologists using a web browser-based image viewer. Total nuclear score was calculated from semi-quantitatively scored eight nuclear features. The molecular profile of RAS and BRAF genes was determined by Sanger sequencing. Results: Total nuclear score ranging 0 to 24 could differentiate BRAF-like tumors from RAS-like tumors with a cut-off value of score 14. The interobserver agreement was the highest for the assessment of nuclear pseudoinclusions (NPIs) but the lowest for nuclearelongation and sickle-shaped nuclei. NPIs were found in tumors with BRAFV600E mutation, but not in tumors with RAS-like mutations. Total nuclear scores were significantly higher for tumors with BRAFV600E than for those with RAS-like mutations (P<0.001). Conclusion: Our results suggest that NPIs and high nuclear scores have diagnostic utility as rule-in markers for differentiating PTC with BRAFV600E mutation from benign or borderline follicular tumors with RAS-like mutations. Relaxation of rigid criteria for nuclear features resulted in an overdiagnosis of PTC. Immunostaining or molecular testing for BRAFV600E mutation is a useful adjunct for cases with high nuclear scores to identify true PTC.
Plasmonically induced magnetic field in graphene-coated nanowires
Kuzmin, Dmitry A.,Bychkov, Igor V.,Shavrov, Vladimir G.,Temnov, Vasily V.,Lee, Hyoung-In,Mok, Jinsik OPTICAL SOCIETY OF AMERICA 2016 Optics letters Vol.41 No.2
<P>In this Letter, we investigate a magnetic field induced by guiding plasmonic modes in graphene-coated nanowire via an inverse Faraday effect. Magnetic field distribution for different plasmonic modes has been calculated. It has been shown that a magnetic field has a vortex-like distribution for some plasmonic modes. The possibility of producing magnetic field distribution that rotates along the nanowire axis and periodically depends on azimuthal angle has been demonstrated. (C) 2016 Optical Society of America</P>