Elemental characteristics of sialoliths extracted from a patient with recurrent sialolithiasis

Buyanbileg Sodnom-Ish,Mi Young Eo,Kezia Rachellea Mustakim,Yun Ju Cho,Soung Min Kim 대한구강악안면외과학회 2024 대한구강악안면외과학회지 Vol.50 No.2

The exact mechanism of sialolith formation has yet to be determined. Recurrence of sialolithiasis is rare, affecting only 1%-10% of patients. The current study presents a case of recurrent stones that occurred twice on the right submandibular gland 6 months postoperative and 7 months after reoperation in a 48-year-old female patient. The stones were analyzed using histology, scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy (TEM). The first stone showed a three-layered structure with a poorly mineralized peripheral multilayered zone, highly mineralized middle layer, and the central nidus. The stones were composed of Ca, C, O, Cu, F, N, P, Si, Zn, and Zr. In TEM, compact bi-layered bacterial cell membrane was found on the peripheral layer and the central nidus of the stone as well as exosomes in the central nidus. The results demonstrated the essential components of sialolith formation, including bacteria, inflammatory exosomes, and exfoliated salivary epithelial cells that cooperatively underwent the pathogenetic progresses of central nidus formation, induction of compact zone calcification of the middle layer, and repeated subsequent deposition in the peripheral multilayer zone. The rapid recurrence could have resulted from residual pieces of a sialolith acting as the nidus of bacterial infection.

Acquired synechia of the tongue to the mouth floor

Buyanbileg Sodnom-Ish,Truc Thi Hoang Nguyen,Mi Young Eo,Yun Ju Cho,Soung Min Kim,Jong Ho Lee 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.5

Sodium hydroxide or caustic soda is a corrosive agent that can cause extensive damage to the oral mucosa, lips, and tongue when ingested either accidentally or intentionally. These injuries include microstomia, shallow vestibule, ankyloglossia, speech impairment, loss of teeth and impairment in facial expression. In the present article, we report a unique case of tongue adhesion to the mouth floor and its surgical management in a 66-year-old female patient, who had a history of caustic soda ingestion.

An accurate diagnosis of odontogenic cutaneous sinus tract by different computed tomography unit setting

Buyanbileg Sodnom-Ish,Mi Young Eo,Soung Min Kim 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.1

Due to their rarity and the lack of associated dental symptoms, odontogenic cutaneous sinus tracts (OCSTs) are often misdiagnosed and confused with cutaneous lesions or non-odontogenic infections. It has been estimated that 50% of individuals affected by OCSTs are subjected to inappropriate treatments before the correct diagnosis is established. We describe the diagnosis and treatment of two cases of OCSTs. By using a computed tomography (CT) with soft tissue window setting, the extent of cortical bone destruction and the path of the sinus tract in the soft tissue was easily identified. Thus, we recommend the use of imaging techniques such as CT, which can confirm the odontogenic origin and the exact location of the OCST.

Layered structure of sialoliths compared with tonsilloliths and antroliths

Buyanbileg Sodnom-Ish,Mi Young Eo,Yun Ju Cho,Mi Hyun Seo,Hyeong-Cheol Yang,Min Keun Kim,Hoon Myoung,Soung Min Kim 대한구강악안면외과학회 2024 대한구강악안면외과학회지 Vol.50 No.1

Objectives: The aim of this study was to perform a comparative analysis of the ultrastructural and chemical composition of sialoliths, tonsilloliths, and antroliths and to describe their growth pattern. Materials and Methods: We obtained 19 specimens from 18 patients and classified the specimens into three groups: sialolith (A), tonsillolith (B), and antrolith (C). The peripheral, middle, and core regions of the specimens were examined in detail by histology, micro-computed tomography (micro- CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, and transmission electron microscopy (TEM). Results: In the micro-CT, group A showed alternating radiodense and radiolucent layers, while group B had a homogeneous structure. Group C specimens revealed a compact homogeneous structure. Histopathologically, group A showed a laminated, teardrop-shaped, globular structure. Group B demonstrated degrees of immature calcification of organic and inorganic materials. In group C, the lesion was not encapsulated and showed a homogeneous lamellar bone structure. SEM revealed that group A showed distinct three layers: a peripheral multilayer zone, intermediate compact zone, and the central nidus area; groups B and C did not show these layers. The main elemental components of sialoliths were O, C, Ca, N, Cu, P, Zn, Si, Zr, F, Na, and Mg. In group B, a small amount of Fe was found in the peripheral region. Group C had a shorter component list: Ca, C, O, P, F, N, Si, Na, and Mg. TEM analysis of group A showed globular structures undergoing intra-vesicular calcification. In group B, bacteria were present in the middle layer. In the outer layer of the group C antrolith, an osteoblastic rimming was observed. Conclusion: Sialoliths had distinct three layers: a peripheral multilayer zone, an intermediate compact zone and the central nidus area, while the tonsillolith and antrolith specimens lacked distinct layers and a core.

Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma

Buyanbileg Sodnom-Ish,Mi Young Eo,Hoon Myoung,이종호,Soung Min Kim 대한구강악안면외과학회 2022 대한구강악안면외과학회지 Vol.48 No.1

Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGS-based technique, and potential salivary biomarker candidates in OSCC using NGS.

Atraumatic Removal of Displaced Implant in the Fatty Bony Marrow

Buyanbileg Sodnom-Ish,어미영,Truc Thi Hoang Nguyen,Yun Ju Cho,김명주,김성민 대한구강악안면임플란트학회 2019 대한구강악안면임프란트학회지 Vol.23 No.3

A 53-year-old Korean female was referred to the Department of Oral and Maxillofacial Surgery at the Seoul National University Dental Hospital. The patient’s chief complaint and concern involved the occasional feeling of discomfort and pain in the region of the lower right second molar. Panoramic radiograph revealed a #47 implant fixture that was dislocated horizontally deep in the fatty degenerated area of the posterior mandible. A rare case of implant displacement into the fatty degenerated area of the posterior mandible caused inferior alveolar nerve (IAN) compression. Fatty degeneration is a condition that occurs in mostly elderly female patients due to aging and is inevitable. We recommend accurate preoperative evaluation using radiographic imaging techniques such as computer tomography and histopathological analysis for differential diagnosis. Endoscopic intraoperative examinations can reduce the invasiveness of the surgery and provide accuracy in examining the intactness of the IAN. This case report suggests the efficacy of the selected method of treatment and, the removal of the displaced implant and decompression of the IAN using endoscopic visualization followed by 8 months of healing and two-stage implant installation with guided bone regeneration in cases of related implant complications.

A 10-year survival rate of tapered self-tapping bone-level implants from medically compromised Korean patients at a maxillofacial surgical unit

Buyanbileg Sodnom-Ish,Mi Young Eo,Myung Joo Kim,Soung Min Kim 대한악안면성형재건외과학회 2023 Maxillofacial Plastic Reconstructive Surgery Vol.45 No.-

Background The 10-year survival rate of dental implants in healthy subjects is 90–95%. While in healthy individuals, dental implants have become commonplace to solve problems of edentulism, whether dental implant treatment is optimal in patients with systemic disease remains unclear. The purpose of this study is to investigate the clinical outcomes of tapered, sand-blasted, and acid-etched internal submerged dental implants installed in medically compromised patients in our maxillofacial surgical unit. Methods A total of 1019 Luna® dental implants were placed in 333 patients at the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. Kaplan–Meier survival estimates after 10 years of follow-up were computed for healthy vs. medically compromised patients. Results The 10-year follow-up survival rate of 1019 Luna® dental implants in the Korean maxillofacial surgical unit was 97.0% with a mean follow-up of 41.13 ± 35.13 months (0–120 months). The survival rate was 97.0%, in which 31 implants were failed during the follow-up. Cumulative 10-year implant survival rates were 99.4% in healthy individuals without systemic disease and 95.9% in patients with systemic disease. Conclusions Comparable success and survival rates were achieved with those of implants in healthy patients. Preoperative general health assessments including laboratory test results and checking the previous medication records are essential in diagnosing any unrecognized conditions for improved implant success rates in medically compromised patients.

Oral Manifestation of Unknown Hematopoietic Malignancy

오현준,Buyanbileg Sodnom-Ish,어미영,이주영,허경회,김성민 대한치의학회 2022 Journal of korean dental science Vol.15 No.2

Burkitt lymphoma is a highly aggressive type of hematopoietic malignancy that is comparatively common in children and young people. It is important that Burkitt lymphoma be diagnosed as early as possible for prompt intervention due to its rapidly progressive, high-grade malignant nature. Dentists, especially maxillofacial surgeons, can play a life-saving role in patients with such unknown malignancy as the first clinical or radiological manifestation might occur in the oral region.

Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features

Cho, Seongji,Sodnom-Ish, Buyanbileg,Eo, Mi Young,Lee, Ju Young,Kwon, Ik Jae,Myoung, Hoon,Yoon, Hye Jung,Kim, Soung Min The Korean Association of Oral and Maxillofacial S 2022 대한구강악안면외과학회지 Vol.48 No.5

The specific muscular structure of the tongue greatly affects margin shrinkage and tumor invasion, making the optimal surgical margin controversial. This study investigated surgical margin correlated prognosis of TSCC (tongue squamous cell carcinoma) according to margin location and its value, and the histopathologic factors which are suggestive of tumor invasion. And we would like to propose defining of the surgical margin for TSCC via prognosis according to location and margin values. We reviewed 45 patients diagnosed with TSCC who visited Seoul National University Dental Hospital (SNUDH) (Seoul, Republic of Korea) from 2010 to 2019, who were managed by a single surgical team. Patient clinical and pathological data of patients were retrospectively reviewed, and in 36 out of 45 patients, the pathologic parameters including the worst pattern of invasion (WPOI) and tumor budding were investigated via diagnostic histopathology slide reading. When standardized with as 0.25 cm anterior margins, as 0.35 cm deep margin, there was no significant difference in disease specific survival (DSS) or loco-regional recurrence-free survival (LRFS). Additionally, there was a non-significant difference in DSS and LRFS at the nearest margin of 0.35 cm (P_DSS=0.276, P_LRFS=0.162). Aggressive WPOI and high tumor budding showed lower survival and recurrence-free survival, and there were significant differences in close margin and involved margin frequencies. In TSCC, the value and location of the surgical margin did not have a significant relationship with prognosis, but WPOI and tumor budding suggesting the pattern of muscle invasion affected survival and recurrence-free survival. WPOI and tumor budding should be considered when setting an optimal surgical margin.

Radiographic evaluation before surgical extraction of impacted third molar to reduce the maxillary sinus related complication

Seo Mi Hyun,Sodnom-Ish Buyanbileg,Eo Mi Young,Myoung Hoon,Kim Soung Min 대한구강악안면외과학회 2023 대한구강악안면외과학회지 Vol.49 No.4

Objectives: Surgical extraction of maxillary third molars is routine in departments devoted to oral and maxillofacial surgery. Because maxillary third molars are anatomically adjacent to the maxillary sinus, complications such as oroantral fistula and maxillary sinusitis can occur. Here we explore the factors that can cause radiographic postoperative swelling of the maxillary sinus mucosa after surgical extraction. Materials and Methods: This retrospective study reviewed the clinical records and radiographs of patients who underwent maxillary third-molar extraction. Preoperative panoramas, Waters views, and cone-beam computed tomography were performed for all patients. The patients were divided into two groups; those with and those without swelling of the sinus mucosa swelling or air-fluid level in a postoperative Waters view. We analyzed the age and sex of patients, vertical position, angulation, number of roots, and relation to the maxillary sinus between groups. Statistical analysis used logistic regression and P<0.05 was considered statistically significant. Results: A total of 91 patients with 153 maxillary third molars were enrolled in the study. Variables significantly related to swelling of the maxillary sinus mucosa after surgical extraction were the age and the distance between the palatal cementoenamel junction (CEJ) and the maxillary sinus floor (P<0.05). Results of the analysis show that the relationship between the CEJ and sinus floor was likely to affect postoperative swelling of the maxillary sinus mucosa. Conclusion: Maxillary third molars are anatomically adjacent to the maxillary sinus and require careful handling when the maxillary sinus is pneumatized to the CEJ of teeth.