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Benjamin R. Ellison,Jeffrey H. Burton,Daniel S. Hsia 대한소아내분비학회 2020 Annals of Pediatirc Endocrinology & Metabolism Vol.25 No.1
Purpose: This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio. Methods: Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters. Results: The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2=0.61, P=0.02) in the type 1 diabetes group. Conclusion: Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children.
Identifiability and Privacy in Pluripotent Stem Cell Research
Isasi, R.,Andrews, Peter W.,Baltz, Jay M.,Bredenoord, Annelien L.,Burton, P.,Chiu, I.M.,Hull, S.,Jung, J.W.,Kurtz, A.,Lomax, G.,Ludwig, T.,McDonald, M.,Morris, C.,Ng, H.,Rooke, H.,Sharma, A.,Stacey, G Cell Press 2014 Cell stem cell Vol.14 No.4
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy. Here we provide guidance for determining data sharing thresholds for human pluripotent stem cell research aimed at a wide range of stakeholders, including research consortia, biorepositories, policy-makers, and funders.