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Efficacy evaluation of syringe pump developed for continuous drug infusion
Jung, Bongsu,Seo, Kwang-Suk,Kwon, Suk Jin,Lee, Kiyoung,Hong, Suyong,Seo, Hyounsoon,Kim, Gi-Young,Park, Geun-Mook,Jeong, Juhee,Seo, Soowon The Korean Dental Society of Anesthsiology 2016 Journal of Dental Anesthesia and Pain Medicine Vol.16 No.4
Background: In dental intravenous sedation, continuous intravenous infusion of a low-dose drug requires an infusion pump such as a syringe pump. To develop a new syringe pump for clinical use, the functions of the pump must meet certain international standards. Various safety and efficacy tests must be performed on the syringe pump, as stipulated by these standards, and an approval must be received from the approving agency based on such test results. Methods: The authors of the present study developed a novel syringe pump and performed efficacy evaluation by testing its infusion speed at 1 and 25 ml/h, and infusion performance testing at 2 and 24 h. Moreover, performance evaluation was conducted by comparing the novel pump to an existing pump with the infusion speed varied from 1 to 5 ml/h. Results: In the efficacy testing on the newly developed syringe pump, infusion with the infusion speed initially set to 1 ml/h resulted in infusion speeds of 1.00 and 0.99 ml/h in the 2- and 24-h assessment, respectively. Changing the infusion speed setting to 25 ml/h resulted in an infusion speed of 25.09 and 23.92 ml/h in the 2- and 24-h assessment, respectively. These results show no significant differences when compared with other commercially available pumps. Conclusions: The efficacy testing of the newly developed syringe pump showed the accuracy to be within tolerance. Based on these findings, we believe that the newly developed syringe pump is suitable for clinical use.
박테리아 운동 추진 구조 시스템의 생물리학적 이해와 인공적 프로펠러 모터 시스템과의 비교
정봉수(Bongsu Jung) 창조론오픈포럼 2014 창조론오픈포럼 Vol.8 No.2
In this paper, the author presents biophysical understanding of bacterial flagellum structure and comparison with man?made motor systems. Bacterial flagellar motor system is as one of the most sophisticated and wonderful nanomachines. The flagellar motor system is a great intelligent design in Biological, Biophysical, Mechanical, and Mathematical aspects. The author proposes that there is a package design theory in nature as a sophisticated intelligent design concept.
최봉수(Bongsu Choi),홍기찬(Ki Chan Hong),남재작(Jae Jak Nam),임정은(Jung-Eun Lim),이현용(Hyeon Yong Lee),최용범(Yong-Beom Choi),주진호(Jin Ho Joo),양재의(Jae E Yang),옥용식(Yong Sik Ok) 韓國雜草學會 2009 Weed&Turfgrass Science Vol.29 No.1
바이오에너지 생산을 위해 국가정책으로 확대 재배되고 있는 유채의 수확 후 잔유물을 녹비로 환원할 경우 벼 재배지에서 잡초발생과 생육억제에 미치는 영향을 평가하였다. 유채 추출무루에 의한 상추종자의 발아율은 꼬투리 추출물에서 농도 증가에 따라 억제 효과가 가장 높았는데 1.3%와 2.5% 농도에서 각각 20%와 80%까지 억제시켰고 5% 농도에서는 전혀 발아하지 못했다. 그러나 뿌리 추출물에서는 대조구와 차이가 없었다. 상추종자의 초기생육은 모든 추출물의 농도가 증가함에 따라 지상부의 생육은 촉진시킨 반면 지하부의 생육은 억제시켰는데 이는 토양으로부터 양분과 수분의 흡수에 영향을 미쳐 식물의 생육을 억제시키는 원인이 될 것으로 판단된다. 한편 유채의 녹비환원에 따른 잡초의 발생은 관행처리구의 6종/pot의 초종을 확인한 것에 비해 3종/pot으로 현저히 감소시켰으며 발생본수도 88% 억제시켰다. 이는 잡초의 생장에도 영향을 미쳤는데 관행처리구에 비해 유채만을 녹비환원한 처리구에서 건물생산량을 85% 억제시켜 지속농업을 위한 유채의 녹비이용 가능성을 제시할 수 있을 것으로 판단된다. In recent, rapeseed (Brassica napus) has been cultivated as a biomass resource for biodiesel production in the southern part of Korea. Objective of this research was to evaluate the potential of rapeseed residue on suppression of weed growth in rice-rapeseed double cropping system. Rates of lettuce (Lactuca sativa L.) seed germination were reduced as the incorporation rate of aqueous pod extracts increased. The similar patterns were observed by the treatment of aqueous pod extracts. Radicle length of lettuce seedling was significantly reduced as aqueous extracts concentration increased. However, hypocotyl length of lettuce seedling showed opposite trend. Rapeseed residue incorporation as green manure inhibited the occurrence of weed species more than 50% compared to the conventional rice cropping system in the pot experiment. Subsequently, rapeseed residue inhibited weed density and biomass by 88% and 85%, respectively, compared to the conventional cultivation. These findings suggested that the utilization of rapeseed residue as green manure can be an alternative practice to control weeds in rice-rapeseed double cropping system.
최봉수(Bongsu Choi),전원태(Weon-Tai Jeon),이용환(Yong-Hwan Lee),김민태(Min-Tae Kim),엄순표(Sun-Pyo Eum),오계정(Gae-Jung Oh),조현숙(Hyun-Suk Cho),박태선(Tae-Seon Park),성기영(Ki-Yeong Seong) 韓國雜草學會 2011 Weed&Turfgrass Science Vol.31 No.4
녹비작물의 이용은 화학비료를 대체할 뿐만 아니라 토양의 지속성을 유지시킬 수 있는 방법 중의 하나이다. 본 연구에서는 동계기간 지속적으로 헤어리베치와 보리를 재배하고 이를 토양환원한 뒤 벼를 재배하는 윤작체계가 벼의 수량과 논 잡초 발생에 미치는 영향을 평가하였다. 손제초구에서 벼의 수량은 관행구와 비교하여 헤어리베치 재배구 및 헤어리베치와 보리 혼파구에서 각각 93%와 90%의 수량을 확보하였으나 보리 재배구는 79%수준이었다. 무제초구에서는 헤어리베치 재배구에서 관행구와 비슷한 수준이었고 헤어리베치와 보리 혼파구는 83%, 보리재배구는 54%수준으로 수량이 감소하였다. 벼의 최고분얼기의 논에서 발생한 잡초는 관행구에서는 물달개비가 포함된 6종이었고, 헤어리베치 재배구와 보리 재배구는 각 5종, 헤어리베치와 보리 혼파구는 2종(여뀌바늘, 돌피)이 발생하였다. 이들 잡초의 건물중은 헤어리베치 재배구와 보리 재배구에서 관행구보다 감소하였고 헤어리베치와 보리 혼파구에서 증가하였다. 헤어리베치 재배구에서는 방동사니과 잡초의 발생이 현저히 감소되었다. 피의 발생량은 관행구를 비롯하여 모든 처리구에서 다른 잡초보다 현저히 낮았으나 피가 차지하는 건물중 비율은 현저히 증가하였다. The use of green manure crop is one of the methods for alternative of chemical fertilizer as well as maintain of soil sustainability, therefore we evaluated the effect of green manure crops on rice growth and weed occurrence in rice-green manure crop double cropping system. The treatments consisted of incorporation of hairy vetch, barley or combined hairy vetch and barley without any agrochemical or fertilizer. In hand weeding, rice yield in hairy vetch only or hairy vetch and barley incorporated fields was attained by 90% and 93% of the conventional practice, respectively, while the value in barley incorporated fields was just 79%. Although the rice yields were lower than the hand weed control, similar trends in non-weed control were observed among all treatments. At maximum tillering stage, occurred weeds in hairy vetch, barley or hairy vetch and barley incorporated fields were five, five and two species, respectively, while those in conventional practice were six species. Also, the dry weight of weeds in hairy vetch and barley incorporated fields was decreased by 33% and 53% compared to it of conventional practice, while the value in hairy vetch and barley incorporated field was increased by 34%. Among all treatments, although occurrence density of Echinochloa crus-galli was lower than another weed species, the dry weight of it significantly increased. These results suggested that although continuous incorporation of proper amount of legume green manure crops was possible to productivity insurance of crop, but to attain it was essential to the effective management of weeds.
Controlled Microfluidic Synthesis of Nanoscale Lipid Vesicles
Sunghak CHOI,Bongsu KANG,Keesung KIM,Ho-sup JUNG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Controlling the size of liposome has critical roles in drug delivery system1. Various size of pure lipid vesicles ranging 50-400 ㎚ were synthesized according to flow rate ratio (FRR) in two solvents, ethanol and IPA. In ethanol, smaller liposomes were obtained due to its low viscosity and high diffusivity. Three-dimensional numerical simulation suggests a parameter predicting liposome size with a linear relation as a characteristic of for self-assembly which interpret the experimental results not only according to FRRs but also solvents. Moreover, the effect of membrane rigidity is also analyzed by adding cholesterols and short-chain phospholipids. On addition of cholesterols, the membrane properties were enhanced so that the size of liposomes increased from 40 ㎚ to 530 ㎚. On the other hands, interposition of short-chain lipids disarranged the alignment of bilayer membrane, which enabled the membrane to be degraded so that the size of liposome decreases. On addition of the short-chain lipids the size of liposome linearly decreases but the gradient is slightly low comparing to the addition of cholesterol (130-230 ㎚).