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Increased vulnerability to physical stress by inactivation of NdgR in Streptomyces coelicolor.
Lee, Bo-Rahm,Yi, Da-Hye,Song, Eunjung,Bhatia, Shashi Kant,Lee, Ju Hee,Kim, Yun-Gon,Park, Sung-Hee,Lee, Yoo Kyung,Kim, Byung-Gee,Yang, Yung-Hun Humana Press 2015 Applied biochemistry and biotechnology Vol.175 No.8
<P>The antibiotic production and spore formation process in Streptomyces coelicolor need complex decision making processes by several regulatory units. These regulatory units are involved in both primary and secondary metabolism. As a result, most regulators have several functions, and those are worthwhile themes to study about different functions of a known regulator. In this study, a deletion mutant of ndgR, which encodes the nitrogen-dependent growth regulator, was examined by the cell viability test, TEM, and growth in N-acetylglucosamine/asparagine (GlcNAc/Asn) liquid medium. The results of the study show that NdgR is also involved in the structure of the cell membrane affecting survival under physical shocks. Deletion of ndgR leads to abnormal cell membrane resulting in the vulnerable cells to physical stress caused by shaking with beads in liquid culture condition. This empirical observation is the first meaningful explanation to why ndgR mutant could not grow well in a liquid minimal medium due to the defect of N-acetylglucosamine (GlcNAc) utilization and phospholipid synthesis.</P>
화학 반응기 모델을 이용한 희박 예혼합 메탄-공기 연소의 NOx 생성 경로 연구
이보람(Bo Rahm Lee),박정규(Jung Kyu Park),이민철(Min Chul Lee) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5
In this study the predictions of NOx in methane-air lean premixed combustion in JSR were carried out with GRI 3.0 methane-air combustion mechanism and Zeldovich, nitrous oxide, prompt, and NNH NO formation mechanism by using CHEMKIN code. The information from CFD modeling for combustor is analyzed and represented as an arrangement of reactor elements. The results are compared to the JSR experimental data of Rutar for the validation of the model. The chemical pathway most likely to form the NO in methane-air lean-premixed combustion was investigated. The results obtained with the 4 different NO mechanisms for residence time(2-4㎳) and pressure(3, 4.7, 6.5 atm) are compared and discussed.
앱타머와 단백질간 가교를 이용한 바이오마커 진단 방법 개발
이보람(Bo-rahm Lee),김진우(Ji-nu Kim),김병기(Byung-Gee Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.4
The detection of biomarkers is an important issue for disease diagnosis. However, many systems are not suitable to detect the biomarker itself directly. For direct detection of biomarker proteins in human serum, a new affinity-capture method using aptamers combined with the mass spectrometry was suggested. Since signals from protein samples cannot be amplified, modified chromatin immunoprecipitation (ChIP) and subsequent cross-linking with formaldehyde between aptamers and target proteins were used not to lose the captured target proteins, which allowed us to perform a harsh washing step to remove the non-specifically bound proteins. As a model system, a thrombin aptamer was used as a bait and thrombin as a target protein. Using our modified ChIP and affinity-capture method, non-specific binding proteins on the beads decreased significantly, suggesting that our new method is efficient and can be applied to developing diagnosis systems for various biomarkers.
제트 혼합 반응기 내 희박 예혼합 메탄-공기 연소의 NO 생성 예측을 위한 화학 반응기 모델링
이보람(Bo-Rahm Lee),박정규(Jung-Kyu Park),이도용(Do-Yong Lee),이민철(Min-Chul Lee),박원식(Won-Shik Park) 대한기계학회 2010 大韓機械學會論文集B Vol.34 No.4
제트 혼합 반응기(JSR) 내의 NOx와 같은 배출물질을 예측하기 위해서 화학반응기 모델을 개발했다. 본 연구에서는 JSR에 대한 화학반응기 모델로서 two-PSR 모델이 채택되었다. CHEMKIN 코드와 4가지 NO 생성 메커니즘을 포함한 GRL 3.0 메탄-공기 연소 메커니즘을 이용해서 JSR내의 희박 예혼합 메탄-공기 연소의 NO 생성예측을 실시하였다. 모델의 검증을 위해서 계산된 결과를 Rutar의 실험 데이터와 비교하였다. NO 생성의 중요파라미터와 4 가지 NO 경로의 기여도를 조사하였다. 화염 영역에서는 prompt 메커니즘이 주된 경로이고 화염후 영역에서는 Zeldovich 메커니즘이 주된 경로이다. 희박 예혼합 조건에서는 N2O 메카니즘이가 화염 및 화염후 영역 모두에서 중요한 경로이다. A chemical reactor model (CRM) was developed for a jet stirred reactor (JSR) to predict the emission of exhaust such as NOx. In this study, a two-PSR model was chosen as the chemical reactor model for the JSR. The predictions of NO formation in lean premixed methane-air combustion in the JSR were carried out by using CHEMKIN and GRI 3.0 methane-air combustion mechanism which include the four NO formation mechanisms. The calculated results were compared with Rutar's experimental data for the validation of the model. The effects of important parameters on NO formation and the contributions of the four NO pathways were investigated. In the flame region, the major pathway is the prompt mechanism, and in the post flame region, the major pathway is the Zelodovich mechanism. Under the lean premixed condition, the N2O mechanism is the important pathway in both flame and postflame regions.
Yenna Lee,Bo-Rahm Kim,Geun-Hyung Kang,Gwan Jae Lee,Young Joo Park,Haeryoung Kim,Hak Chul Jang,최성희 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.6
Background: Farnesoid X receptor (FXR), a bile acid–activated nuclear receptor, is a potent regulator of glucose and lipid metabolism as well as of bile acid metabolism. Previous studies have demonstrated that FXR deficiency is associated with metabolic derangements, including atherosclerosis and nonalcoholic fatty liver disease (NAFLD), but its mechanism remains unclear. In this study, we investigated the role of FXR in atherosclerosis and NAFLD and the effect of peroxisome proliferator-activated receptor (PPAR) agonists in mouse models with FXR deficiency. Methods: En face lipid accumulation analysis, liver histology, serum levels of glucose and lipids, and mRNA expression of genes related to lipid metabolism were compared between apolipoprotein E (ApoE)−/− and ApoE−/−FXR−/− mice. The effects of PPARα andPPARγ agonists were also compared in both groups of mice. Results: Compared with ApoE−/− mice, ApoE−/−FXR−/− mice showed more severe atherosclerosis, hepatic steatosis, and higher levels of serum cholesterol, low-density lipoprotein cholesterol, and triglycerides, accompanied by increased mRNA expression of FAS,ApoC2, TNFα, IL-6 (liver), ATGL, TGH, HSL, and MGL (adipocytes), and decreased mRNA expressions of CPT2 (liver) and Tfam (skeletal muscle). Treatment with a PPARα agonist, but not with a PPARγ agonist, partly reversed atherosclerosis and hepatic steatosis, and decreased plasma triglyceride levels in the ApoE−/−FXR−/− mice, in association with increased mRNA expression of CD36 and FATP and decreased expression of ApoC2 and ApoC3 (liver). Conclusion: Loss of FXR is associated with aggravation of atherosclerosis and hepatic steatosis in ApoE-deficient mice, which could be reversed by a PPARα agonist through induction of fatty acid uptake, β-oxidation, and triglyceride hydrolysis.