Inward and Outward Starburst Feedbacks and Growth of Supermassive Black Holes

Bing-Xiao Xu,Xue-Bing Wu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.4

Based on the major merger scenario we propose a simple model to investigate the relation between the starburst and the central active galactic nuclei (AGN). We argue that the momentum feedback from the starburst rather than from the central black hole (BH) plays the most important role in the main growth stage of both the BH and the bulge. We suggest that for small scale, the momentum feedback from the starburst may exist in two directions. The outward starburst feedback can blow some gas away to halt the star formation activity, and the growth of the BH is regulated by the inward starburst feedback. The final BH mass is directly related to the maximum star formation rate based on this scenario, and such a relation can be used to derive the MBH. and MBH.Mbulge relations, which are consistent with recent observations and simulations. Our result suggests that the BH undergoes its main growth in an obscured environment, which may be just the “pre-quasar” phase, as some authors previously argued.

Protein-protein Interaction Network Analyses for Elucidating the Roles of LOXL2-delta72 in Esophageal Squamous Cell Carcinoma

Wu, Bing-Li,Zou, Hai-Ying,Lv, Guo-Qing,Du, Ze-Peng,Wu, Jian-Yi,Zhang, Pi-Xian,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Lysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase (LOX) family, is a copper-dependent enzyme that catalyzes oxidative deamination of lysine residues on protein substrates. LOXL2 was found to be overexpressed in esophageal squamous cell carcinoma (ESCC) in our previous research. We later identified a LOXL2 splicing variant LOXL2-delta72 and we overexpressed LOXL2-delta72 and its wild type counterpart in ESCC cells following microarray analyses. First, the differentially expressed genes (DEGs) of LOXL2 and LOXL2-delta72 compared to empty plasmid were applied to generate protein-protein interaction (PPI) sub-networks. Comparison of these two sub-networks showed hundreds of different proteins. To reveal the potential specific roles of LOXL2- delta72 compared to its wild type, the DEGs of LOXL2-delta72 vs LOXL2 were also applied to construct a PPI sub-network which was annotated by Gene Ontology. The functional annotation map indicated the third PPI sub-network involved hundreds of GO terms, such as "cell cycle arrest", "G1/S transition of mitotic cell cycle", "interphase", "cell-matrix adhesion" and "cell-substrate adhesion", as well as significant "immunity" related terms, such as "innate immune response", "regulation of defense response" and "Toll signaling pathway". These results provide important clues for experimental identification of the specific biological roles and molecular mechanisms of LOXL2-delta72. This study also provided a work flow to test the different roles of a splicing variant with high-throughput data.

A NOTE ON THE GENERALIZED MYERS THEOREM FOR FINSLER MANIFOLDS

Wu, Bing-Ye Korean Mathematical Society 2013 대한수학회보 Vol.50 No.3

In this note we establish a generalized Myers theorem under line integral curvature bound for Finsler manifolds.

Comprehensive Bioinformation Analysis of the MRNA Profile of Fascin Knockdown in Esophageal Squamous Cell Carcinoma

Wu, Bing-Li,Luo, Lie-Wei,Li, Chun-Quan,Xie, Jian-Jun,Du, Ze-Peng,Wu, Jian-Yi,Zhang, Pi-Xian,Xu, Li-Yan,Li, En-Min Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

On the denominators of ε-harmonic numbers

Bing-Ling Wu,Xiao-Hui Yan 대한수학회 2020 대한수학회보 Vol.57 No.6

Let $H_n$ be the $n$-th harmonic number and let $v_n$ be its denominator. Shiu proved that there are infinitely many positive integers $n$ with $v_n =v_{n+1}$. Recently, Wu and Chen proved that the set of positive integers $n$ with $v_n = v_{n+1}$ has density one. They also proved that the same result is true for the denominators of alternating harmonic numbers. In this paper, we prove that the result is true for the denominators of $\varepsilon$-harmonic numbers, where $\varepsilon=\{ \varepsilon_i \}_{i=1}^\infty $ is a pure recurring sequence with $\varepsilon_i\in \{-1,1\}$.

COMPARISON THEOREMS IN RIEMANN-FINSLER GEOMETRY WITH LINE RADIAL INTEGRAL CURVATURE BOUNDS AND RELATED RESULTS

Wu, Bing-Ye Korean Mathematical Society 2019 대한수학회지 Vol.56 No.2

We establish some Hessian comparison theorems and volume comparison theorems for Riemann-Finsler manifolds under various line radial integral curvature bounds. As their applications, we obtain some results on first eigenvalue, Gromov pre-compactness and generalized Myers theorem for Riemann-Finsler manifolds under suitable line radial integral curvature bounds. Our results are new even in the Riemannian case.

A fiber beam element model for elastic-plastic analysis of girders with shear lag effects

Wu-Tong Yan,Bing Han,Li Zhu,Yu-Ying Jiao,Hui-bing Xie 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.32 No.5

This paper proposes a one-dimensional fiber beam element model taking account of materially non-linear behavior, benefiting the highly efficient elastic-plastic analysis of girders with shear-lag effects. Based on the displacement-based fiber beam-column element, two additional degrees of freedom (DOFs) are added into the proposed model to consider the shear-lag warping deformations of the slabs. The new finite element (FE) formulations of the tangent stiffness matrix and resisting force vector are deduced with the variational principle of the minimum potential energy. Then the proposed element is implemented in the OpenSees computational framework as a newly developed element, and the full Newton iteration method is adopted for an iterative solution. The typical materially non-linear behaviors, including the cracking and crushing of concrete, as well as the plasticity of the reinforcement and steel girder, are all considered in the model. The proposed model is applied to several test cases under elastic or plastic loading states and compared with the solutions of theoretical models, tests, and shell/solid refined FE models. The results of these comparisons indicate the accuracy and applicability of the proposed model for the analysis of both concrete box girders and steel-concrete composite girders, under either elastic or plastic states.

THE INSTABILITIES OF ACCRETION DISKS WITH RADIAL ADVECTION

WU XUE-BING The Korean Astronomical Society 1996 Journal of The Korean Astronomical Society Vol.29 No.suppl1

The local instabilities of accretion disks were extensively studied, with the considerations of radial advection, thermal diffusion and different disk geometry, dominated pressure and optical depth. Two inertial-acoustic modes in a geometrically thin, radiative cooling dominated disk depart from each other if very little advection is included. A geometrically slim, advection-dominated disk is found to be always stable if it is optically thin. However, if it is optically thick, the thermal diffusion has no effect on the stable viscous mode but has a significant contribution to enhance the thermal instability.

Clinical Application of Endoscopic Inguinal Lymph Node Resection after Lipolysis and Liposuction for Vulvar Cancer

Wu, Qiang,Zhao, Yi-Bing,Sun, Zhi-Hua,Ni, Jing,Wu, Yu-Zhong,Shao, Heng-Hua,Qu, Jun-Wei,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Aim: To examine lymph nodes obtained after lipolysis and liposuction of subcutaneous fat of the inguinal region of female vulvar cancer patients to explore the feasibility of clinical application. Methods: The field of operation was on the basis of the range of the conventional resection of inguinal lymph nodes. We injected lipolysis liquid fanwise, started liposuction after 15-20 minutes; then the subcutaneous fatty tissue was sucked out clearly by suction tube. We selected the first puncture holes located on 2-3 cm part below anterior superior spine, the others respectively being located 3cm and 6cm below the first for puncturing into the skin, imbedding a trocar to intorduce $CO_2$ gas and the specular body, and excise the lymph nodes by ultrasonic scalpel. The surgical field chamber was set with negative pressure drainage and was pressured with a soft saline bag after surgery. Results: A lacuna emerged from subcutaneous of the inguinal region after lipolysis and liposuction, with a wide fascia easily exposed at the bottom where lymph nodes could be readily excised. The number of lymph nodes of ten patients excised within the inguinal region on each side was 4-18. The excised average number of lymph nodes was 11 when we had mature technology. Conclusion: Most of adipose tissue was removed after lipolysis and liposuction of subcutaneous tissue of inguinal region, so that the included lymph nodes were exposed and easy to excise by endoscope. This surgery avoided the large incision of regular surgery of inguinal region, the results indicating that this approach is feasible and safe for used as an alternative technology.

A Vision-Based Collision Warning System by Surrounding Vehicles Detection

( Bing-fei Wu ),( Ying-han Chen ),( Chih-chun Kao ),( Yen-feng Li ),( Chao-jung Chen ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.4

To provide active notification and enhance drivers` awareness of their surroundings, a vision-based collision warning system that detects and monitors surrounding vehicles is proposed in this paper. The main objective is to prevent possible vehicle collisions by monitoring the status of surrounding vehicles, including the distance to the other vehicles in front, behind, to the left and to the right sides. In addition, the proposed system collects and integrates this information to provide advisory warnings to drivers. To offer the correct notification, an algorithm based on features of edge and morphology to detect vehicles is also presented. The proposed system has been implemented in embedded systems and evaluated on real roads in various lighting and weather conditions. The experimental results indicate that the vehicle detection ratios were higher than 97% in the daytime, and appropriate for real road applications.