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RISS 인기검색어
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- 저자 : Bei-Bei Luo (검색결과 3 건)
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Zheng, Ping,Pu, Bei,Yu, Bing,He, Jun,Yu, Jie,Mao, Xiangbing,Luo, Yuheng,Luo, Junqiu,Huang, Zhiqing,Luo, Chenggui,Wang, Shaohui,Chen, Daiwen Asian Australasian Association of Animal Productio 2018 Animal Bioscience Vol.31 No.6
Objective: The objective of this experiment was to compare the effects of adding 130 mg/kg Cu from either copper sulfate (CS) or tribasic copper chloride (TBCC) on growth performance, mineral deposition in tissues, and the excretion in feces of pigs as well as changes in the mineral contents in tissues and feces when the supplemental Cu level was decreased from 130 mg/kg to 10 mg/kg. Methods: A total of 72 pigs ($32.6{\pm}1.2kg$) were randomly assigned to a CS diet or a TBCC diet with 6 pens per treatment. The trial lasted 102 d and included 3 phases (phase 1, 1 to 30 d; phase 2, 31 to 81 d; and phase 3, 82 to 102 d). The supplemental levels of Cu in the 2 treatments were 130 mg/kg in phase 1 and 2 and 10 mg/kg in phase 3. Results: The results showed that pigs fed the CS diet tended to have higher average daily gain than pigs fed the TBCC diet during d 1 to 81 (p<0.10). Compared with CS, TBCC increased the activities of aspartate transaminase (AST), ceruloplasmin, and superoxide dismutase in serum on d 30 (p<0.05). The TBCC decreased the Cu level in the liver on d 81 (p<0.05) and increased the Mn level in the liver on d 102 (p<0.05). The concentration of Cu in feces sharply decreased when the supplemental Cu level in diet changed from 130 mg/kg to 10 mg/kg in both diets (p<0.05). Conclusion: The result suggested that TBCC and CS had no significant difference on growth performance but TBCC had higher activities of AST and antioxidant enzymes and lower liver Cu than CS when pigs fed diets with 130 mg Cu /kg diet.
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L1-L2 Reading Comprehension Transferability in Factual and Inferential Tasks
Young-Sun Moon,Bei-Bei Luo 한국응용언어학회 2017 응용 언어학 Vol.33 No.1
The current study aimed to investigate the transferability of reading comprehension abilities from L1 to L2 between languages with distant orthographies. Furthermore, this study examined the degree of transferability based on different levels of tasks and different L2 proficiency groups. The scores of sixty-five Korean EFL high school students’ Trial-CSAT of English and Korean language tests were used as criteria for their level of L2 proficiency and L1 reading comprehension, in addition to a self-designed English reading test with factual and inferential tasks as L2 reading comprehension. This study has statistically analyzed the acquainted data and identified the following research findings: (1) Korean EFL students’ L1 reading comprehension ability did transfer to their English reading comprehension ability; (2) Korean EFL students’ L1 inferential reading comprehension ability was more transferable to L2 reading comprehension than their L1 factual reading comprehension ability; (3) A meaningful transferability of Korean inferential reading comprehension ability in English reading comprehension test (especially in English inferential reading tasks) was observed on the lower proficiency EFL learners, whereas no obvious transferability of Korean reading comprehension ability was found in higher proficiency EFL learners.
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Lijun Yu,Min Meng,Yun Bao,Chao Zhang,Bei Gao,Rina Sa,Wenyuan Luo 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.9
Purpose: Epirubicin is one of the most effective drugs against osteosarcoma. miR-1301 is involved in the occurrence and developmentof osteosarcoma. Whether miR-1301 is responsible for the chemosensitivity of osteosarcoma cells to epirubicin remainslargely unknown. Materials and Methods: U2OS and SAOS-2 cells were treated with various concentrations of epirubicin. Flow cytometry was employedto evaluate cell apoptotic rate. Cell proliferation was measured by Cell Counting Kit-8 assay. Western blot and quantitativereal-time polymerase chain reaction were utilized to detect the expressions of B-cell lymphoma-2 (Bcl-2), Bcl-2 assaciated X protein(Bax), cleaved-caspase-3, cleaved-poly (ADP-ribose) polymerases (PARP1), TP53-regulated inhibitor of apoptosis 1 (TRIAP1),and microRNA-1301 (miR-1301). The relationship between miR-1301 and TRIAP1 was determined by luciferase reporter assay. Results: Epirubicin inhibited proliferation in a dose-dependent manner, induced apoptosis, decreased the expression of Bcl-2,and increased the expressions of Bax, cleaved-caspase-3, and cleaved-PARP1 in osteosarcoma cells. miR-1301 was downregulatedin U2OS and SAOS-2 cells. Importantly, epirubicin significantly increased the levels of miR-1301. Overexpression of miR-1301suppressed proliferation and promoted apoptosis. Interestingly, those effects were enhanced by epirubicin. In contrast, miR-1301depletion attenuated the epirubicin-mediated anti-osteosarcoma effect. miR-1301 negatively regulated the expression of TRIAP1in U2OS and SAOS-2 cells. Furthermore, epirubicin inhibited the mRNA and protein levels of TRIAP1 by upregulating miR-1301levels. Epirubicin suppressed cell proliferation by downregulating TRIAP1. Conclusion: miR-1301 was implicated in the chemosensitivity of osteosarcoma to epirubicin by modulating TRIAP1.
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