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Rafael Herrera Alvarez,Fabio Luis Nogueira Natal,Maria Teresa Carvalho Pinto Ribela,Beatriz Elane de Almeida,João Ezequiel de Oliveira,Paolo Bartolini 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.4
Ovarian stimulation with commercial preparations of equine chorionic gonadotropin (eCG) produces extremely variable responses indomestic animals, ranging from excessive stimulation to practically no stimulation, when applied on the basis of their declared unitage. Thisstudy was conducted to analyze four commercial preparations from different manufacturers via reversed-phase HPLC (RP-HPLC) incomparison with a reference preparation and an official International Standard from the World Health Organization. The peaks obtained bythis qualitative and quantitative physical–chemical analysis were compared using an in vivo bioassay based on the ovarian weight gain ofprepubertal female rats. The RP-HPLC data showed one or two peaks close to a main peak (tR = 27.9 min), which were related to the in vivobioactivity. Commercial preparations that have this altered peak showed very little or no in vivo activity, as demonstrated by rat ovarian weightand in peripubertal gilts induced to ovulate. Overall, these findings indicate that RP-HPLC can be a rapid and reliable tool to reveal changesin the physicochemical profile of commercial eCG that is apparently related to decreased biological activity of this hormone.
( Alvaro March-rodriguez ),( Beatriz Bellosillo ),( Alberto Alvarez-larran ),( Carles Besses ),( Ramon M Pujol ),( Agusti Toll ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2
Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or intolerant to hydroxyurea. We report a 72 year-old man patient with polycythemia vera who developed multiple cutaneous squamous cell carcinomas (cSCCs) with keratoacanthoma-like histological features while on treatment with ruxolitinib. Similar lesions have been reported in an isolated patient who also received ruxolitinib. Our case confirms that ruxolitinib may induce eruptive cSCCs with characteristic clinical and histological features that differentiate them from conventional non-drug induced lesions. Moreover, we performed a mutational panel analysis of the tumors. The lack of specific mutations in these tumors suggests an impairment of immunosurveillance in the origin of the cutaneous lesions. Frequent and thorough dermatological examinations in patients receiving ruxolitinib with a history of photodamage, skin cancer and/or previous hydroxyurea intake is thus recommended. (Ann Dermatol 31(2) 204∼208, 2019)
Osteomyelitis: A Descriptive Study
Laura Prieto-Pérez,Ramón Pérez-Tanoira,Elizabet Petkova-Saiz,Concepción Pérez-Jorge,Cristina Lopez-Rodriguez,Beatriz Alvarez-Alvarez,Jorge Polo-Sabau,Jaime Esteban 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.1
Background: To analyze the incidence and clinical-microbiological characteristics of osteomyelitis (OM) in a tertiary Spanish hospital. Methods: All cases diagnosed with OM between January 2007 and December 2010 were retrospectively reviewed. The variablesexamined include epidemiological characteristics, risk factors, affected bone, radiographic changes, histology, microbiological cultureresults, antibiotic treatment, and the need for surgery. Results: Sixty-three cases of OM were diagnosed. Twenty-six patients (41.3%) had acute OM whereas 37 patients (58.7%) wereclassified as chronic OM. OM may result from haematogenous or contiguous microbial seeding. In this group, 49 patients (77.8%)presented with OM secondary to a contiguous source of infection and 14 patients had hematogenous OM (22.2%). Staphylococcusaureus was the most commonly found microorganism. Conclusions: OM mainly affected patients with risk factors related to the presence of vascular diseases. Antibiotic treatmentmust be guided by susceptibility patterns of individual microorganisms, although it must be performed together with surgery inmost of the cases.