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      • SCOPUSKCI등재

        Protective effect of ethyl acetate extract of Ishige okamurae against carbon tetrachloride-induced acute liver injury in rats

        Kang, Sohi,Yang, Wonjun,Oh, Hanseul,Bae, Yeonji,Ahn, Meejung,Kang, Min Chul,Ko, Ryeo Kyeong,Kim, Gi Ok,Lee, Jun Hwa,Hyun, Jin Won,Moon, Changjong,Shin, Taekyun The Korean Society of Veterinary Science 2011 大韓獸醫學會誌 Vol.51 No.4

        Several compounds and extracts isolated from a brown alga, Ishige (I.) okamurae, exhibit anti-oxidant and anti-inflammatory effects. The present study investigated whether the ethyl acetate (EtOAc) fraction of I. okamurae (EFIO) could ameliorate carbon tetrachloride ($CCl_{4}$)-induced hepatotoxicity in rats. Sprague-Dawley rats were intraperitoneally (i.p.) administered with EFIO at 10 or 50 mg/kg per day for 2 consecutive days before $CCl_{4}$ injection (3.3 mL/kg, i.p.). Twenty four hours later, the rats were anesthesized with diethyl ether and dissected. Pretreatment with EFIO significantly reduced the increased serum levels of alanine aminotransferase and aspartate aminotransferase in $CCl_{4}$-treated rats. Pretreatment with EFIO also significantly inhibited the reduced activities of superoxide dismutase and catalase in the $CCl_{4}$-injured liver. Histopathological evaluations showed that hemorrhage, hepatocyte necrosis, inflammatory cell infiltration, and fatty degeneration induced by $CCl_{4}$ treatment were ameliorated by the administration of EFIO. Additionally, liver immunohistochemical analyses revealed the marked reduction in ED1-positive monocyte-like macrophages in EFIO-pretreated rats given $CCl_{4}$. These results suggest that EFIO ameliorates $CCl_{4}$-induced liver injury, possibly through the inhibition of oxidative stress.

      • KCI등재

        Low-dose-rate gamma radiation aggravates titanium dioxide nanoparticle-induced lung injury in mice

        Kang Sohi,Lee Hae-June,Son Yeonghoon,Bae Min Ji,Jo Wol Soon,Park Jun Hong,Jeong Sohee,Moon Changjong,Shin In-Sik,Lee Chang Geun,Kim Joong-Sun 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2

        Background Radiation damage and the cellular response has been studied in various direction, however, the synergic effects of radiation damage with environmental pollution on cells or tissues remained poorly understood. In particular, gene and pathway regulation by low-dose radiation exposure remains unclear. Dust and air pollution in Asian countries contains metal oxide and titanium dioxide nanoparticles (TiO2NPs), which exacerbate respiratory distress. Objective To explore the synergic injury of radiation damage with air pollution, we examined the effects of low-dose-rate radiation with TiO2NPs on pulmonary response in mice. Results Thirty-six mice (C57bl/6) were divided into six groups: sham, 0.1 Gy, 0.3 Gy, TiO2NPs, TiO2NPs + 0.1 Gy, and TiO2NPs + 0.3 Gy group. Mice were irradiated at a low-dose-rate at a dose of 0.1 Gy (0.182 mGy/h) and 0.3 Gy (0.554 mGy/h) for 24 days and exposed to TiO2NPs by intranasal injection at a dose of 0.1 mg daily for 4 days (from day 21 to 24). The combination of low-dose-rate radiation and TiO2NPs caused significantly more pulmonary inflammation via MAPK phosphorylation in mice than did each stimulus alone. Conclusion We conclude that while exposure to each of these two distinct stimuli alone does not cause notable lung damage, they may potentially cause lung damage when combined owing to their synergistic effects. Therefore, we should pay attention to the possible combined effects of low-dose radiation and exposure to TiO2NPs, considering their potential danger in patients with respiratory problems.

      • KCI등재

        A Case of Nasal Septum Gossypiboma 14 Years After Septorhinoplasty

        Yang Seungjoon,Bae Sohi,Seo Jayeong,Cho Hyung-Ju,Kim Chang-Hoon,하종균 대한비과학회 2022 Journal of rhinology Vol.29 No.2

        Gossypiboma, an infrequent surgical complication, describes a mass of cotton material inadvertently left in the body cavity after an operation. It is an extremely rare iatrogenic complication of nasal surgery, with only a few cases reported in literature to date. Here we present a case of gossypiboma in the nasal septum of a 35-year-old male patient who previously underwent septorhinoplasty fourteen years prior. He was treated by endoscopic endonasal surgery to remove the lesion. Pathologic findings showed a foreign body (gauze filament) with a giant cell reaction. This report will be helpful for treating patients with similar histories in the future.

      • KCI등재

        중뇌주변부 뇌조의 지주막하출혈로 인한 시각로 손상

        이승재(Seung Jae Lee),배소희(Sohi Bae),김혜영(Hye Young Kim) 대한안과학회 2021 대한안과학회지 Vol.62 No.3

        목적: 시각로의 병변은 영상에서 미세한 변화만을 일으켜 놓치는 경우가 종종 보고되므로 세심한 관찰이 요구된다. 저자들은 중뇌주변부 뇌조의 지주막하출혈에 동반된 시각로 손상 1예를 경험하고 이를 보고하고자 한다. 증례요약: 26세 여자 환자가 1개월 전부터 인지한 우측 시야가 불편하다는 증상을 주소로 내원하였다. 과거력상 40일 전 교통사고로 인한 양측 전두엽의 외상성 경막하출혈로 입원 치료를 받았으며 퇴원 후 우측 시야장애를 인지하고 안과로 내원하였다. 시력은 양안1.0이며 우안에 구심동공운동장애가 있었다. 시야검사상 우측의 동명성 반맹이 있었고, 빛간섭단층촬영상 양안에서 좌측 황반부 신경절세포-내망상층의 두께가 얇아진 소견이 관찰되어 좌측 시각로의 병변을 의심하였다. 자기공명영상의 T2 강조영상에서 전두엽의 경막하출혈 외에는 시각 경로에 이상 소견이 발견되지 않았으나, 자화강조영상에서 왼쪽 중뇌주변부 뇌조에 미세한 지주막하출혈이 관찰되었으며 이로 인한 시각로의 손상으로 진단할 수 있었다. 결론: 저자들은 좌측 시각로 손상이 의심되는 26세 여자 환자에서 자기공명영상의 자화강조영상에서 중뇌주변부 뇌조의 지주막하출혈을 확인하고 이를 보고하는 바이다. Purpose: A case of optic tract injury caused by subarachnoid hemorrhage in the perimesencephalic cistern is reported. Case summary: A 26-year-old female with a history of traumatic subdural hemorrhage along the bilateral frontal convexity presented with a right visual field defect. Her visual acuity was 1.0 in both eyes. Slit-lamp examination and fundus examination were not remarkable. There was a relative afferent pupillary defect in the right eye. A Humphrey visual field test revealed right homonymous hemianopsia. Optical coherence tomography showed left homonymous hemiatrophy of the ganglion cell-inner plexiform layer in both eyes. Magnetic resonance imaging was performed. Susceptibility-weighted images showed minimal subarachnoid hemorrhage in the left perimesencephalic cistern, and the patient was confirmed to have optic tract injury due to subarachnoid hemorrhage. Conclusions: We report a case of optic tract injury in a 26-year-old patient caused by subarachnoid hemorrhage in the perimesencephalic cistern, which was confirmed by susceptibility-weighted images.

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