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- 저자 : Bachelor, Robert J. (검색결과 4 건)
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SeongJu Choi,Hyunsun Lim,Cheungsoo Ha,Heemin Choi,Bachelor’s degree,Jaeseok Chae,Jun-Ku Lee 대한정형외과학회 2024 Clinics in Orthopedic Surgery Vol.16 No.4
Background: Pediatric trigger digit (TD) does not appear at birth but is diagnosed after birth by finding a flexion contracture of the thumb or other fingers. The reported incidence of pediatric TDs varies from 0.5 to 5 cases per 1,000 live births without sex-specific predominance. We performed a nationwide large-scale study to determine the prevalence and incidence of pediatric TDs and analyzed operative treatment for pediatric TDs using the National Health Insurance data of South Korea. Methods: Patients with pediatric TDs, aged 0–10 years between 2011 and 2020, were included in this study. Children born between 2011 and 2015 were set as the reference population and followed up until 2020. We calculated the prevalence and incidence rates of pediatric TDs according to age and sex and analyzed the operation rate, age at surgery, time interval from initial diagnosis to surgery, and follow-up period. Patient selection and treatment were based on International Classification of Diseases, 10th Revision (ICD-10). Results: The prevalence rates of pediatric TDs ranged from 0.063% to 0.084%. Girls had a higher prevalence rate (0.066%–0.094%) than boys (0.060%–0.075%). The total incidence rate was 77.6/100,000 person-years, and the incidence rate was higher in girls (84.8) than in boys (70.7). Among 2,181,814 children born between 2011 and 2015, 12,729 were diagnosed with pediatric TDs, of which 1,128 (8.9%) underwent operative management. The means of age at initial diagnosis, age at surgery, and the time interval between diagnosis and operation were 2.76 ± 1.91 years, 3.79 ± 2.19 years, and 1.15 ± 1.71 years, respectively. Conclusions: High prevalence and incidence rates of pediatric TDs were found in 2- to 3-year-old patients. Among pediatric patients, 8.9% underwent operative management that was most frequently conducted between 2 and 3 years of age (within 1 year of initial diagnosis).
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Secular trends in cesarean sections and risk factors in South Korea (2006-2015)
( Ho Yeon Kim ),( Dokyum Lee ),( Jinsil Kim ),( Eunjin Noh Bachelor ),( Ki-hoon Ahn ),( Soon-cheol Hong ),( Hai-joong Kim ),( Min-jeong Oh ),( Geum Joon Cho ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.4
Objective This study aimed to investigate trends in the rate of cesarean sections (CSs) in South Korea from 2006 to 2015 and identify the risk factors associated with these changes. Methods Using the National Health Insurance Corporation dataset, all women who gave birth between 2006 and 2015 were included in the study. We investigated 1) the mode of delivery, 2) the complication rates during pregnancy (i.e., preeclampsia and placenta previa), and 3) pre-pregnancy factors (body mass index, hypertension [HTN], diabetes mellitus [DM], and other pre-existing medical conditions), and their trends during the study period. Results Over 10 years, the rate of CS increased from 36.3% in 2006 to 40.6% in 2015 (P<0.01). The rate of CS increased in primiparous women, women with multiple pregnancy, and women with preeclampsia. Maternal age and the incidence of placenta previa also increased. In contrast, the rate of vacuum deliveries and vaginal birth after CS decreased during the study period. The rate of women with pre-pregnancy obesity and DM increased, but the rate of women with pre-pregnancy HTN decreased. Conclusion The rate of CS in South Korea increased from 2006 to 2015. This trend may reflect changes in the rate of different risk factors. Identifying the causes of the increasing CS trend observed in this study will allow clinicians to monitor these factors and possibly reduce the rate of CS.
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Strum, John S.,Nwosu, Charles C.,Hua, Serenus,Kronewitter, Scott R.,Seipert, Richard R.,Bachelor, Robert J.,An, Hyun Joo,Lebrilla, Carlito B. American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.12
<P>Site-specific glycosylation (SSG) of glycoproteins remains a considerable challenge and limits further progress in the areas of proteomics and glycomics. Effective methods require new approaches in sample preparation, detection, and data analysis. While the field has advanced in sample preparation and detection, automated data analysis remains an important goal. A new bioinformatics approach implemented in software called GP Finder automatically distinguishes correct assignments from random matches and complements experimental techniques that are optimal for glycopeptides, including nonspecific proteolysis and high mass resolution liquid chromatography/tandem mass spectrometry (LC/MS/MS). SSG for multiple N- and O-glycosylation sites, including extensive glycan heterogeneity, was annotated for single proteins and protein mixtures with a 5% false-discovery rate, generating hundreds of nonrandom glycopeptide matches and demonstrating the proof-of-concept for a self-consistency scoring algorithm shown to be compliant with the target-decoy approach (TDA). The approach was further applied to a mixture of N-glycoproteins from unprocessed human milk and O-glycoproteins from very-low-density-lipoprotein (vLDL) particles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-12/ac4006556/production/images/medium/ac-2013-006556_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac4006556'>ACS Electronic Supporting Info</A></P>
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De Jong, Wim H.,Hoffmann, Sebastian,Lee, Michelle,Kandá,rová,, Helena,Pellevoisin, Christian,Haishima, Yuji,Rollins, Beau,Zdawczyk, Austin,Willoughby, Jamin,Bachelor, Michael,Schatz, Timot Elsevier 2018 Toxicology in vitro Vol.50 No.-
<P><B>Highlights</B></P> <P> <UL> <LI> Alternative in vitro testing of medical device extracts for irritation is possible. </LI> <LI> Reconstructed human epidermis (RhE) model detects presence of irritant in extracts. </LI> <LI> High predictivity RhE model for presence of strong irritants in material extracts. </LI> <LI> Predictivity in saline or sesame oil extract depends on hydrophilicity of irritant. </LI> <LI> Four positive polymer test materials containing a known irritant were evaluated. </LI> </UL> </P>
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