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RISS 인기검색어
- 검색키워드
- 저자 : B.B. Mistry (검색결과 3 건)
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Synthesis, antioxidant and anticancer screenings of berberine–indole conjugates
Mistry, B.,Keum, Y. S.,Kim, D. H. Springer Science + Business Media 2016 Research on chemical intermediates Vol.42 No.4
<P>A variety of heterocyclic nitrogen cores in the form of indole moieties were linked to the natural isoquinoline alkaloid molecule berberine to achieve anticipated antioxidant and anticancer properties. An efficient synthetic pathway afforded final compounds 5a-j, which were tested in vitro for antioxidant potency using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical (ABTS) bioassays, and for anticancer activity using sulforhodamine B (SRB) assay against HeLa and Caski cancer cell lines. Moreover, the toxic nature of the resultant molecules was investigated using Madin-Darby canine kidney cells. The therapeutic indices of 5a-j were more appreciable against the Caski than HeLa cell line, in which compounds with electron-releasing alkyl or alkoxy functional group on indole entity as well as azaindole derivative performed well. In addition, these compounds were well endowed with antioxidant properties, in addition to the equal antioxidant effect of the compound with electron-withdrawing chlorine atom within indole entity. Adequate confirmation of the structure of the final analogues was achieved using Fourier-transform infrared (FT-IR), H-1 nuclear magnetic resonance (NMR), and mass spectroscopy and elemental (CHN) analysis.</P>
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Behaviour of asymmetric building with double variable frequency pendulum isolator
Soni, D.P.,Mistry, B.B.,Panchal, V.R. Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.1
Presented in this paper is the behaviour of asymmetric building isolated by the double variable frequency pendulum isolator (DVFPI). The DVFPI is an adoption of single variable frequency pendulum isolator (VFPI). The geometry and coefficient of friction of top and bottom sliding surfaces can be unequal. The governing equations of motion of the building-isolation system are derived and solved in incremental form. The analysis duly considers the interaction of frictional forces in the two principal directions developed at each sliding surface of the DVFPI. In order to investigate the behaviour of the base isolation using the DVFPI, the coupled lateral-torsional response is obtained under different parametric variations for a set of six far-fault earthquake ground motions and criterion to optimize its performance is proposed. Further, influences of the initial time period, coefficient of friction and frequency variation factors at the two sliding surfaces are investigated. The numerical results of the extensive parametric study help in understanding the torsional behaviour of the structure isolated with the double sliding surfaces as in the DVFPI. It is found that the performance of the DVFPI can be optimized by designing the top sliding surface initially softer and smoother relative to the bottom one.
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Behaviour of asymmetric building with double variable frequency pendulum isolator
V.R. Panchal,D.P. Soni,B.B. Mistry 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.1
Presented in this paper is the behaviour of asymmetric building isolated by the double variable frequency pendulum isolator (DVFPI). The DVFPI is an adoption of single variable frequency pendulum isolator (VFPI). The geometry and coefficient of friction of top and bottom sliding surfaces can be unequal. The governing equations of motion of the building-isolation system are derived and solved in incremental form. The analysis duly considers the interaction of frictional forces in the two principal directions developed at each sliding surface of the DVFPI. In order to investigate the behaviour of the base isolation using the DVFPI, the coupled lateral-torsional response is obtained under different parametric variations for a set of six far-fault earthquake ground motions and criterion to optimize its performance is proposed. Further, influences of the initial time period, coefficient of friction and frequency variation factors at the two sliding surfaces are investigated. The numerical results of the extensive parametric study help in understanding the torsional behaviour of the structure isolated with the double sliding surfaces as in the DVFPI. It is found that the performance of the DVFPI can be optimized by designing the top sliding surface initially softer and smoother relative to the bottom one.
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