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        Permanent Deformation Characteristics of Warm Asphalt Binders under Reduced Aging Conditions

        Ashok Julaganti,Rajan Choudhary,Abhinay Kumar 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.1

        Warm Mix Asphalt (WMA) technologies allow a 20 to 40°C reduction in production temperatures of asphalt mixes. These technologies are often synergistically combined with modified asphalt binders to tackle the increased production temperature requirements with these binders. Because of lower production temperatures, the asphalt binders containing WMA additives undergo reduced short-term aging and thus need to be examined for permanent deformation behavior at different reductions in production temperatures. The present study evaluates permanent deformation characteristics of warm asphalt binders as function of short-term aging temperature, modified binder type, and various dosages of a wax-based WMA additive: Sasobit. Experimental variables included are: three short-term aging temperatures (163°C, 143°C, and 123°C), two modified asphalt binders (polymer, and crumb rubber modified), and three contents of WMA additive (1%, 2%, and 3%). Warm binders as well as control binders are characterized in terms of viscosity, failure temperature, temperature sweep, frequency sweep, and multiple stress creep and recovery tests. WMA additive compensates the reduced stiffness of binders on being aged at lower temperatures, as rheological parameters of warm binders aged at 143°C and 123°C compare well with control binders. Statistical models for the rheological parameters as function of the experimental variables are also developed.

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        Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

        Manoj Kumar Sharma,Sumeet Kainth,Sachin Kumar,Ankit Bhardwaj,Hemant Kumar Agarwal,Rakhi Maiwall,Kapil Dev Jamwal,Saggere Muralikrishna Shasthry,Ankur Jindal,Ashok Choudhary,Lovkesh Anand,Rajender Mal 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2

        Background/Aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks. Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture. Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture.

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