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Santo, Vitor E.,Prieto, Susana,Testera, Ana M.,Arias, Francisco J.,Alonso, Matilde,Mano, Joao F.,Rodriguez-Cabello, Jose Carlos Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.1
A bioactive and multifunctional elastin-like polymer (ELP) was produced by genetic engineering techniques to develop new artificial matrices with the ability to mimic the extracellular matrix (ECM). The basic composition of this ELP is a thermo- and pH-sensitive elastin pentapeptide which has been enriched with RGD-containing domains, the RGD loop of fibronectin, for recognition by integrin receptors on their sequence to promote efficient cell attachment. Hydrogels of this RGD-containing polymer were obtained by crosslinking with hexamethylene diisocyanate, a lysine-targeted crosslinker. These materials retain the "smart" nature and temperature-responsive character, and the desired mechanical behavior of the elastin-like polymer family. The influence of the degree of crosslinking on the morphology and properties of the matrices were tested by calorimetric techniques and scanning electron microscopy (SEM). Their mechanical behavior was studied by dynamical mechanical analysis (DMA). These results show the potential of these materials in biomedical applications, especially in the development of smart systems for tissue engineering.
Santo, Vitor E.,Prieto, Susana,Testera, Ana M.,Arias, Francisco J.,Alonso, Matilde,Mano, Joao F.,Rodriguez-Cabello, Jose Carlos Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.1
A bioactive and multifunctional elastin-like polymer (ELP) was produced by genetic engineering techniques to develop new artificial matrices with the ability to mimic the extracellular matrix (ECM). The basic composition of this ELP is a thermo- and pH-sensitive elastin pentapeptide which has been enriched with RGD-containing domains, the RGD loop of fibronectin, for recognition by integrin receptors on their sequence to promote efficient cell attachment. Hydrogels of this RGD-containing polymer were obtained by crosslinking with hexamethylene diisocyanate, a lysine-targeted crosslinker. These materials retain the "smart" nature and temperature-responsive character, and the desired mechanical behavior of the elastin-like polymer family. The influence of the degree of crosslinking on the morphology and properties of the matrices were tested by calorimetric techniques and scanning electron microscopy (SEM). Their mechanical behavior was studied by dynamical mechanical analysis (DMA). These results show the potential of these materials in biomedical applications, especially in the development of smart systems for tissue engineering.
Ordinola-Zapata Ronald,Crepps Joseph T.,Arias Ana,Lin Fei 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.1
Objectives: The aim of this study was to evaluate the apical pressure generated by 2 endodontic irrigation needles and the GentleWave system in mandibular molars. Materials and Methods: The mesial and distal root canals of 12 mandibular molars were irrigated with a 30-gauge close-end needle or with a 30-gauge open-end needle. Procedures were performed in the mesial and distal canals. The GentleWave procedure and irrigation at 1 mm from the apex in the distal roots using an open-end needle were used, respectively, as negative and positive controls. The apical pressure was measured using a data acquisition pressure setup. Apical pressure exerted by the different needles in the 2 different canal types was statistically compared using 2-way analysis of variance. Results: Significant differences were found in the apical pressure for both needles and the canal type. The lowest values were obtained with close-end needles and in mesial canals. Negative apical pressure values were obtained using GentleWave. Conclusions: The needle and the canal type influenced the apical pressure. The GentleWave procedure produced negative apical pressure.
Pleural effusion secondary to minoxidil in a peritoneal dialysis patient
Palomar, Rosa,Morales, Pedro,Sanz de Castro, Saturnino,Tasis, Ana,Rodrigo, Emilio,Piñ,era, Celestino,Ruiz, Juan Carlos,Ferná,ndez-Fresnedo, Gema,Martin de Francisco, Angel Luis,Arias, Manu Oxford University Press 2004 Nephrology, dialysis, transplantation Vol.19 No.10