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RISS 인기검색어
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- 저자 : Anthony Nelson (검색결과 5 건)
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Mark Anthony Rotor,Hamid Hefazi,Nelson Enano, Jr. Techno-Press 2023 Ocean systems engineering Vol.13 No.3
Tidal stream energy extraction remains a site-specific resource due to the "first generation" criteria requiring high-velocity tidal streams. Most studies on tidal energy and turbine blade design heavily focus on installation sites with higher velocity conditions that are non-existent in tropical countries such as the Philippines. To shorten this gap, this review paper tackles tidal turbine design considerations for low-energetic regions such as the tropics. In-depth discussions of operating principles, methods of analysis, and designs of tidal turbine blades are presented. Notable tidal stream projects around the world are also mentioned in the paper. Also, it provides a perspective on the potential of this renewable energy to produce electricity for various sites in the Philippines. Finally, the paper emphasizes the need for new tidal turbine blade designs to be viable in tropical regions, such as the Philippines.
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Easterhoff, David,Moody, M. Anthony,Fera, Daniela,Cheng, Hao,Ackerman, Margaret,Wiehe, Kevin,Saunders, Kevin O.,Pollara, Justin,Vandergrift, Nathan,Parks, Rob,Kim, Jerome,Michael, Nelson L.,O’Connell, Public Library of Science 2017 PLoS pathogens Vol.13 No.2
<▼1><P>The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody (bnAbs), no plasma bnAb activity was induced. The RV305 (NCT01435135) HIV-1 clinical trial was a placebo-controlled randomized double-blinded study that assessed the safety and efficacy of vaccine boosting on B cell repertoires. HIV-1-uninfected RV144 vaccine recipients were reimmunized 6–8 years later with AIDSVAX B/E gp120 alone, ALVAC-HIV alone, or a combination of ALVAC-HIV and AIDSVAX B/E gp120 in the RV305 trial. Env-specific post-RV144 and RV305 boost memory B cell V<SUB>H</SUB> mutation frequencies increased from 2.9% post-RV144 to 6.7% post-RV305. The vaccine was well tolerated with no adverse events reports. While post-boost plasma did not have bnAb activity, the vaccine boosts expanded a pool of envelope CD4 binding site (bs)-reactive memory B cells with long third heavy chain complementarity determining regions (HCDR3) whose germline precursors and affinity matured B cell clonal lineage members neutralized the HIV-1 CRF01 AE tier 2 (difficult to neutralize) primary isolate, CNE8. Electron microscopy of two of these antibodies bound with near-native gp140 trimers showed that they recognized an open conformation of the Env trimer. Although late boosting of RV144 vaccinees expanded a novel pool of neutralizing B cell clonal lineages, we hypothesize that boosts with stably closed trimers would be necessary to elicit antibodies with greater breadth of tier 2 HIV-1 strains.</P><P><B>Trial Registration:</B> ClinicalTrials.gov NCT01435135</P></▼1><▼2><P><B>Author summary</B></P><P>Developing a successful HIV-1 vaccine remains a high global health priority. Several HIV-1 vaccine trials have been performed with only the RV144 vaccine trial showing vaccine efficacy, albeit modest. No broadly neutralizing antibody activity was identified in RV144 and inducing sterilizing immunity against a complex pathogen like HIV-1 remains a major challenge. Here we characterize the B cell responses after RV144 vaccine-recipients received two additional boosts severals years after the conclusion of the RV144 vaccine trial. Delayed and repetitive boosting of RV144 vaccine-recipients was capable of increasing somatic hypermutation of the Env-reactive antibodies and expanding subdominant pools of neutralizing B cell clonal lineages. These data are pertinent to HIV-1 vaccine-regimen design.</P></▼2>
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Modifying Polydiacetylene Vesicle Compositions to Reduce Non-Specific Interactions
Gumaro Rojas,Priyanka Shiveshwarkar,임부택,Anura Shrestha,Izele Abure,Anthony Nelson,Justyn Jaworski 한국고분자학회 2021 Macromolecular Research Vol.29 No.7
Polydiacetylene (PDA) vesicles provide useful stimuli-responsive behavior as well as by the modular structure afford a means for the design of sensing and delivery systems with tunable target specificity. To reduce inherent non-specific interaction with either anionic or cationic formulations of polydiacetylene vesicles, we explored the use of various lengths of poly(ethylene glycol) (PEG) amphiphiles for integration and polymerization within PDA vesicles. Our results established that as little as 1% of polyethylene glycol amphiphile integration into anionic vesicles was sufficient to significantly reduce non-specific association with mammalian cells. Similarly integrating a low percent of PEG amphiphile content within cationic vesicles could also significantly reduce non-specific cell association, and moreover reduced cytotoxicity. These results may be prove useful in augmenting PDA vesicles formulations for reduced non-specific interaction which is of particularly interest to enhancing selectivity in vesicles designed with integrated targeting moieties for sensing and drug delivery applications.
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Self-Assembled Peptide-Labeled Probes for Agglutination-Based Sensing
Anura Shrestha,임부택,Priyanka Shiveshwarkar,Gumaro Rojas,Izele Abure,Anthony David Nelson,Justyn Jaworski 한국고분자학회 2021 Macromolecular Research Vol.29 No.9
The use of polydiacetylene (PDA) vesicles in sensing systems are widespread due to the interesting optical properties of this stimuli-responsive material; however, agglutination based sensing with PDA have been relatively underutilized. To demonstrate the means for rapidly generating an agglutination probe based on peptide-displaying polydiacetylene vesicles, we implement here the use of a biotin mimetic peptide functionalized to a diacetylene amphiphile for proof-of-concept detection of a multivalent target, specifically streptavidin. Tuning of the vesicle composition revealed a distinct limit in the surface density of peptide amphiphile that could be displayed for this particular peptide sequence. A wide operational detection range was demonstrated, and the result also revealed an effective agglutination response of the PDA-based probe to streptavidin suggesting possible use of future formulations in profiling other multivalent targets.
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