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RISS 인기검색어
- 검색키워드
- 저자 : Priyanka Shiveshwarkar (검색결과 3 건)
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Priyanka Shiveshwarkar,Savier Vega Siurano,Mahri Kadyrova,Natalie Tran,Justyn Jaworski 한국고분자학회 2022 Macromolecular Research Vol.30 No.1
Polydiacetylene based sensors have been used for a variety of sensing applications. Here we demonstrate that diacetylene-containing amphiphiles could be spray processed to provide unique sensor coatings that may be applied to a variety of material surfaces. Utilizing an airbrushing technique, we examined processing parameters to yield spray-on sensors for detecting UV, temperature, as well as chemical/ solvent targets depending on the pendant side chain chemistry of the resulting polydiacetylene coating. We observed that the concentration, carrier solvent, and UV exposure time had a significant effect on the colorimetric response of the sprayed on coating with better responses observed at higher amphiphile concentration and shorter polymerization times. We expect this approach to generating spray-on responsive coatings will provide a widely deployable means for detection that may be customized for a variety of sensing applications.
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Modifying Polydiacetylene Vesicle Compositions to Reduce Non-Specific Interactions
Gumaro Rojas,Priyanka Shiveshwarkar,임부택,Anura Shrestha,Izele Abure,Anthony Nelson,Justyn Jaworski 한국고분자학회 2021 Macromolecular Research Vol.29 No.7
Polydiacetylene (PDA) vesicles provide useful stimuli-responsive behavior as well as by the modular structure afford a means for the design of sensing and delivery systems with tunable target specificity. To reduce inherent non-specific interaction with either anionic or cationic formulations of polydiacetylene vesicles, we explored the use of various lengths of poly(ethylene glycol) (PEG) amphiphiles for integration and polymerization within PDA vesicles. Our results established that as little as 1% of polyethylene glycol amphiphile integration into anionic vesicles was sufficient to significantly reduce non-specific association with mammalian cells. Similarly integrating a low percent of PEG amphiphile content within cationic vesicles could also significantly reduce non-specific cell association, and moreover reduced cytotoxicity. These results may be prove useful in augmenting PDA vesicles formulations for reduced non-specific interaction which is of particularly interest to enhancing selectivity in vesicles designed with integrated targeting moieties for sensing and drug delivery applications.
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Self-Assembled Peptide-Labeled Probes for Agglutination-Based Sensing
Anura Shrestha,임부택,Priyanka Shiveshwarkar,Gumaro Rojas,Izele Abure,Anthony David Nelson,Justyn Jaworski 한국고분자학회 2021 Macromolecular Research Vol.29 No.9
The use of polydiacetylene (PDA) vesicles in sensing systems are widespread due to the interesting optical properties of this stimuli-responsive material; however, agglutination based sensing with PDA have been relatively underutilized. To demonstrate the means for rapidly generating an agglutination probe based on peptide-displaying polydiacetylene vesicles, we implement here the use of a biotin mimetic peptide functionalized to a diacetylene amphiphile for proof-of-concept detection of a multivalent target, specifically streptavidin. Tuning of the vesicle composition revealed a distinct limit in the surface density of peptide amphiphile that could be displayed for this particular peptide sequence. A wide operational detection range was demonstrated, and the result also revealed an effective agglutination response of the PDA-based probe to streptavidin suggesting possible use of future formulations in profiling other multivalent targets.
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