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RISS 인기검색어
- 검색키워드
- 저자 : Annu Gupta (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Assessment of Pharmacokinetic Interaction of Spirulina with Glitazone in a Type 2 Diabetes Rat Model
Annu Gupta,Bandar E. Al-Dhubiab,Ipshita Chattopadhyaya,Anroop Nair,Rachna Kumria,Sumeet Gupta 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.12
The objective of the current study was to assess the possible pharmacokinetic interactions of spirulina with glitazones in an insulin resistance rat model. Wistar male albino rats were equally divided into five groups: insulin resistant rats+spirulina (500 mg/kg)+pioglitazone (10 mg/kg), insulin resistant rats+pioglitazone (10 mg/kg), insulin resistant rats+spirulina (500 mg/kg)+rosiglitazone (10 mg/kg), insulin resistant rats+rosiglitazone (10 mg/kg), and insulin resistant rats + spirulina (500 mg/kg). Described doses of pioglitazone, rosiglitazone, or spirulina were per orally administered and the plasma drug concentrations were determined. The pharmacokinetic parameters such as Tmax, Cmax, AUC0-a, t1/2, and Kel were determined by plotting the drug concentration as a function of time. The data observed in this acute study indicated that there was no statistically significant difference in any of the pharmacokinetic parameters (Tmax, Cmax, AUC0-a, t1/2, and Kel) of glitazones (pioglitazone, rosiglitazone) or spirulina, when they were coadministered. Given the promising results, this study concludes that the coadministration of spirulina does not influence the pharmacokinetics of glitazones in a type 2 diabetes rat model. Further chronic in vivo studies are recommended to assess the real time effect.
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Mukul Gupta,Javed Sheikh,Annu,Ankit Singh 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
The study aims to develop a multifunctionalfinished linen fabric by using an environment-benign, greenand sustainable route. The cellulose-based linen fabric has been functionally modified by aminopolysaccharide (chitosan, CS), zinc oxide nanoparticles (ZnO NPs), andflower extract of medicinal plant,Bombax ceiba. The NPs were stabilized by the extract on chitosan polymeric layer, which was bound onthe fabric through citric acid. Thus, developedfinished fabric, at three different pH values, was examinedfor bending length, tensile strength, crease recovery, UV-protection, antibacterial, and antioxidantactivity. The embedded ZnO NPs have been confirmed through FT-IR, Energy dispersive X-Rayspectroscopy (EDX), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results showed effective crease recovery angle (CRA) and hiked UV protection factor (UPR) withsplendid percent antibacterial activity against Escherichia coli and Staphylococcus aureus (>90%) and highfree radical scavenging ability (80–90%) for the modified fabrics. The durability of the multifunctionalproperties has also been determined by several launderings.
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