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- 검색키워드
- 저자 : Ann Misun Youn (검색결과 3 건)
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Ann Misun Youn,Yong Sup Shin,Sang-Il Park 대한마취통증의학회 2014 Anesthesia and pain medicine Vol.9 No.1
Background: Pulse transit time (PTT), the time it takes a pulsewave to travel from one arterial site to another, is a noninvasiveindicator of arterial stiffness. The main objective of our study wasto compare two common anesthetic techniques using PTT in orderto explore which technique would bring more vascular distention. Methods: Sixty female patients, ages 18–65, classified by ASA1 or 2 undergoing general anesthesia, were randomly allocated intotwo groups, S and P. Group S (n = 30) was inducted with 2 mg/kgof propofol and remifentanil 5.0 ng/ml. Group P (n = 30) was inductedwith propofol 4.0 ug/ml and remifentanil 4.0 ng/ml using a targetcontrolled infusion (TCI) pump. Group S was anesthetically maintainedwith sevoflurane at 1.0 MAC and 1.0 ng/ml remifentanil whilegroup P was anesthetically maintained with propofol 3.0 ug/ml andremifentanil 1.0 ng/ml for 10 minutes. PTT values were obtainedby measuring the distance between the electrocardiographic Rwave, which approximates the opening of the aortic valve, to theradial artery. Three consecutive values of prePTT, postPTT, andcorresponding vital signs were measured and recorded before and10 minutes after anesthetic induction. Results: PrePTT in group S and group P was 240.18 ± 3.66 and239.32 ± 3.69 ms, respectively. Ten minutes after anesthetic induction,postPTT in group S increased to 284.16 ± 4.37 ms whilepostPTT in group P increased to 278.7 ± 4.53 ms (P > 0.05). However, despite the slope of group S (43.98 ± 22.18) being greaterthan group P (39.38 ± 18.39), the difference between the two groupswas statistically insignificant (P = 0.2239). Conclusions: Changes in PTT values were statistically insignificantregarding arterial distension in patients anesthetized with targetcontrolled infusion of propofol compared to those with balancedanesthesia with sevoflurane.
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고영권,Ann Misun Youn,홍부휘,김윤희,신용섭,강포순,윤건정,이원형 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.62 No.6
Background: Reactive oxygen species (ROS) such as superoxide radicals, hydrogen peroxide, nitric oxide, and nitroperoxide, cause oxidative stress which interferes with normal cell functioning, resulting in cell damage. It is reported to be associated with chronic pain, especially neuropathic pain, and inflammatory pain. ROS is also closely related to central sensitization. Therefore, this study was designed to explore the effects of Phenyl N-tert-butylnitrone (PBN), an ROS scavenger, in acute, continuous, and increasing pain caused by central sensitization. Methods: Male Sprague-Dawley rats were divided into 2 groups, an intraperitoneal group (IP) and an intrathecal group (IT), and once again divided into an experimental group and a control group. The experimental group was injected with Phenyl N-tert-butylnitrone (PBN), a free radical scavenger, either intraperitoneally or intrathecally. After inducing pain by injecting formalin into the hind paw, pain behaviors were measured. Lumbar enlargement immmunohistochemistry was performed to assess nitrotyrosine, an oxidative stress marker, to identify the degree of protein nitration. Results: Both experimental groups of IP and IT showed statistically significant decreases in the number of flinches compared to the control group in phase 1 and 2. Immunohistochemical evaluation in the control group revealed an increase in nitrated proteins in the gray matter of the lumbar spinal cord, but a significant decrease in nitrated proteins in the gray matter of lumbar spinal cord of the experimental group. Conclusions: Intraperitoneal and intrathecal administration of PBN decreases analgesic behaviors, allowing us to believe that ROS is mainly responsible for acute pain and central sensitization.
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Cardiac Arrest from Patient Position Change after Spine Surgery on a Jackson Table
홍부휘,윤석화,Ann Misun Youn,Seunghyun Song,Soo-Yong Park,JaGyung Hwang 대한중환자의학회 2019 Acute and Critical Care Vol.34 No.1
The Jackson table has minimal effects on cardiac function because it does not elevate abdominal and thoracic pressures. In addition, it decreases venous congestion and increases exposure of the surgical field. However, the hips and knees are flexed with inappropriate padding, and venostasis is promoted and increased. Pulmonary thromboembolism (PTE) is fatal; thus immediate diagnosis and treatment are essential. However, clinical signs of intraoperative PTE are difficult to discern. Thrombolytic therapy can be considered as first-line therapy, but bleeding limits its use. The authors report a case of PTE resulting from patient positional change after spine surgery, and the use of immediate postoperative recombinant tissue-type plasminogen activator.
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