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- 저자 : Anjila Maharjan (검색결과 3 건)
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Pooja Maharjan,Minki Jin,Daseul Kim,JaeWook Yang,Anjila Maharjan,Meong Cheol Shin,Kwan Hyung Cho,김만수,Kyoung Ah Min 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.10
Ocular drug delivery has been a well-knownroute for the drug administration for the treatment of oculardiseases. However, numerous anatomical and physiologicalbarriers prevailing in the eye itself create considerablechallenges for achieving the necessitated therapeutic efficacyalong with ocular bioavailability. However, recentadvances in nanoengineered strategies hold definite promisesin terms of devising improved ophthalmic medicinesfor the effective drug delivery to target the sites withenhanced ocular bioavailability. Curcumin, a hydrophobicpolyphenol yellow colored compound, and its metabolicreduced product, tetrahydrocurcumin (THC), have beenknown for their beneficial pharmacological functions, suchas anti-inflammatory or anti-oxidant activities at varioustissue sites. However, the low aqueous solubility of thesecompounds results in their poor bioavailability, therebylimiting their widespread application. Therefore, in thepresent study, we investigated the changes in drug solubilityby forming inclusion complexes with differentderivatives of hydroxypropyl (HP)-cyclodextrins (CD). To this end, the spray drying technique was used for nanoengineeringcurcumin or THC-loaded formulations toimprove the stability of formulations during the storage. The formulations were characterized in terms of physicochemicalproperties and cellular permeability. The resultsdemonstrated that the encapsulation of curcumin (or THC)into the HP-CDs significantly increased the drug solubilityand enhanced the corneal and retinal epithelial permeability. Curcumin or THC complexes in HP-CDs withimproved bioavailability also induced anti-oxidant activity(SOD1, CAT1, and HMOX1) in higher levels in the ocularepithelial cells and showed oxidative protection effects inrabbit cornea tissues that will boost up their application inocular medicine.
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Pharmaceutical challenges and perspectives in developing ophthalmic drug formulations
Kyoung Ah Min,Pooja Maharjan,조관형,Anjila Maharjan,Meong Cheol Shin,Cheol Moon 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.2
Ocular drug delivery has been widely recognized as an attractive route for drug administration for cures of ocular diseases. Overall, designing an effective therapy to cure ocular diseases has been considered as a formidable task. Even though some infectious or inflammatory eye diseases could be alleviated by eye drops or ointments, achieving the required therapeutic efficacy along with ocular bioavailability remains a challenge due to the numerous anatomical and physiological barriers prevailing in the eye. Drug delivery to the posterior segment of the eye is yet a more challenging task. In this context, a better understanding of physiologic natures of the eyes and ocular pharmacokinetics would facilitate the development of new drug delivery systems to treat various vision-threatening disorders. For the effective drug delivery to target sites and to enhance the ocular bioavailability, recent progress in formulation strategies using nanotechnologies holds promises in terms of devising improved ophthalmic medicines. Hence, this review presents an overview of various aspects of ocular drug delivery, with a specific emphasis on nanocarrier-based strategies, including physiological barriers in eyes and conventional drug formulations. Recent research on sustained, controlled, and targeted systems for ocular drug delivery was updated as well.
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( Sumitra Ghimire ),( Shreena Shakya ),( Deepa Satyal ),( Anjeela Vetwal ),( Anjila Maharjan ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: A high number of world’s population is affected from thyroid dysfunction. Thyroidism, a highly overriding endocrine disorder, is also encountered in iodine deficient country Nepal with a prevalence rate of 17.42 % in western part of Nepal and 30 % in eastern part of Nepal alone and is presumed to be inclining at high rate. Fluctuation of thyroid hormone level following thyroid dysfunction may cause alteration of liver enzymes thereby, modulating the liver function. Primary assessment of liver function in thyroid disorder patient helps in timely diagnosis, prevention, proper management and cure of possible liver damage. Although, thyroid disorder is prevailing at high rate, limited studies regarding the associated liver disease necessitates the present study. Hence, the present study was commenced to assess the liver function test in thyroid patient. Methods: A total of 105 subjects (35 hyperthyroid, 35 hypothyroid and 35 euthyroid) aged from 20 to 70 years were studied in the Department of Biochemistry, Manmohan Memorial Teaching Hospital. Thyroid hormone profile including Free T3 (FT3), Free T4 (FT4), Thyroid Stimulating Hormone (TSH), and liver function profile covering Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total Protein (TP) and albumin were estimated in the serum of participants using standard protocol. Data were analyzed using SPSS version 20 and Microsoft Excel 2013. Student’s t-test was used to analyze differences in liver parameter of case and control. P-value <0.05 was considered statistically significant. Results: AST and ALT level were increased in 24 (68.5%) and 15 (42.8%) hyperthyroid subjects respectively. Similarly AST and ALT level were increased in 17 (48.5%) and 10 (28.5%) hypothyroid subjects respectively. Level of AST and ALT both increased significantly in hyperthyroid subjects whereas only AST level increased significantly (P-value <0.05) in hypothyroid subjects. Total protein and albumin were found to be decreased significantly (P-value <0.05) in both the study subjects as compared to euthyroid group. Increase in level of ALP was not significant in both the subjects. Conclusions: Potentially adverse changes in liver function parameter such as increase in enzyme activity and decrease in protein and albumin in subjects with thyroid disorder suggest the possible liver injury in near future. Hence, it is essential to screen liver function in every thyroid disorder patients.
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