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      • Open cycle ocean thermal energy conversion using multiple condensers for selective power generation and seawater desalination

        Albert Kim,H.J Kim(김현주),H.S Lee(이호생),S.W Cha(차상원) 한국해양환경·에너지학회 2014 한국해양환경공학회 학술대회논문집 Vol.2014 No.11

        다단 응축기를 이용한 개방형 온도차발전 및 담수화사이클에 대한 기본 설계 및 해석 결과를 진행하였다. 저압 상태에서 증발기에서 증발된 증기는 터빈으로 유입되는 모드, 터빈 및 응축기로 유입되는 모드 및 응축기로 유입되는 모드로 나눌 수 있으며, 각 사이클에 대한 설계 및 해석 결과를 제공하고자 한다. Ocean Thermal Energy Conversion(OTEC) is a method that utilizes the natural temperature gradient that exists in tropical ocean between warm surface water and the deep sea water to generate electricity. When the temperature difference between surface seawater and deep seawater is over 20℃, the system can be run with much better efficiency. Researches for the cases of low temperature differences are also ongoing. As explained above, OC-OTEC uses very fundamental principles of thermal physics, however, its theoretical analysis and design details is significantly lacking in the literature. Optimization techniques were barely studied in terms of power generation and fresh water production. In this light, we proposed a conceptual design of a dual-use OC-OTEC plant applying fundamental issues of heat and mass transfer phenomena, as directly related to performance optimization.

      • 다단 지열 사이클의 기초성능해석

        차상원(S.W Cha),이호생(H.S Lee),Albert Kim,김현주(H.J Kim) 한국해양환경·에너지학회 2014 한국해양환경공학회 학술대회논문집 Vol.2014 No.11

        오늘날 사용가능한 화석연료의 고갈에 따른 에너지 위기 및 지구 환경에 대한 문제점으로 신재생에너지에 대한 관심이 증가하고 있다. 그 중 지열발전을 국내에 적용하는 방안에 대한 기술연구가 다양하게 이뤄지고 있다. 국내에 지열발전을 효과적으로 적용하기 위해 저자는 이전 연구에서 기존의 바이너리 지열 발전시스템에서 기화용 온수를 온배수로 사용하고, 해양심층수를 응축용 냉각수를 사용하여 전력을 생산하는 해양지열발전사이클을 연구하여 기존의 지열발전보다 높은 성능을 확인할 수 있었다. 하지만, 이 역시도 국내에 적용하기에는 충분한 지열열원 얻는 것은 쉽지 않다는 것이 현실이다. 이를 해결하기 위해서 본 논문에서는 기존의 바이너리지열발전 사이클을 Counter flow 또는 Parallel flow로 사이클을 구성하는 방안에 대해 연구를 진행하였다. 작동유체는 기존의 R245fa를 적용하여 사이클 성능해석을 진행하였다. Binary geothermal generation system which utilizes the warm water in geothermal water for vaporization and the cold water in deep ocean water for condensation. The regeneration process increased the efficiency more than the existing geothermal generation system ,and the multi stage process also increased the power of the turbine. Improvement of the multi stage regeneration cycles study on these process respectively or together applied to the cycles. Optimization simulation was conducted for improving the gross power and efficiency with 2 stage rankine cycle and 3 stage rankine cycle for ocean thermal energy conversion(OTEC) according to changing of a counter flow and parallel flow on cycle. Performance analysis of the various components was simulated by using the Aspen HYSYS for analysis of the thermodynamic cycle.

      • KCI등재

        Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague – Dawley rats

        Chunmei Li,ZhezheWang,Guisheng Li,ZhenhuaWang,Jianrong Yang,Yanshen Li,Hongtao Wang,Haizhu Jin,Junhua Qiao,Hongbo Wang,Jingwei Tian,Albert W. Lee,Yonglin Gao 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2

        Background: 20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from redginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming miceand SpragueeDawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observethe persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice andrats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-weekadministration period and a 4-week withdrawal period (recovery period), there were no significantdifferences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical andhematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD50) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, theno-observed-adverse-effect level for female and male SD rats was 180 mg/kg.

      • SCISCIESCOPUS

        Universal process-inert encoding architecture for polymer microparticles

        Lee, Jiseok,Bisso, Paul W.,Srinivas, Rathi L.,Kim, Jae Jung,Swiston, Albert J.,Doyle, Patrick S. Nature Publishing Group, a division of Macmillan P 2014 NATURE MATERIALS Vol.13 No.5

        Polymer microparticles with unique, decodable identities are versatile information carriers with a small footprint. Widespread incorporation into industrial processes, however, is limited by a trade-off between encoding density, scalability and decoding robustness in diverse physicochemical environments. Here, we report an encoding strategy that combines spatial patterning with rare-earth upconversion nanocrystals, single-wavelength near-infrared excitation and portable CCD (charge-coupled device)-based decoding to distinguish particles synthesized by means of flow lithography. This architecture exhibits large, exponentially scalable encoding capacities (>10<SUP>6</SUP> particles), an ultralow decoding false-alarm rate (<10<SUP>−9</SUP>), the ability to manipulate particles by applying magnetic fields, and pronounced insensitivity to both particle chemistry and harsh processing conditions. We demonstrate quantitative agreement between observed and predicted decoding for a range of practical applications with orthogonal requirements, including covert multiparticle barcoding of pharmaceutical packaging (refractive-index matching), multiplexed microRNA detection (biocompatibility) and embedded labelling of high-temperature-cast objects (temperature resistance).

      • SCIESCOPUSKCI등재

        Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats

        Li, Chunmei,Wang, Zhezhe,Li, Guisheng,Wang, Zhenhua,Yang, Jianrong,Li, Yanshen,Wang, Hongtao,Jin, Haizhu,Qiao, Junhua,Wang, Hongbo,Tian, Jingwei,Lee, Albert W.,Gao, Yonglin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2

        Background: 20(S)-ginsenoside-Rg3 (C<sub>42</sub>H<sub>72</sub>O<sub>13</sub>), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming mice and Sprague-Dawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the 26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26 weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observe the persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice and rats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-week administration period and a 4-week withdrawal period (recovery period), there were no significant differences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical and hematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD<sub>50</sub>) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no-observed-adverse-effect level for female and male SD rats was 180 mg/kg.

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