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RISS 인기검색어
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- 저자 : Junhua Qiao (검색결과 2 건)
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Chunmei Li,ZhezheWang,Guisheng Li,ZhenhuaWang,Jianrong Yang,Yanshen Li,Hongtao Wang,Haizhu Jin,Junhua Qiao,Hongbo Wang,Jingwei Tian,Albert W. Lee,Yonglin Gao 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: 20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from redginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming miceand SpragueeDawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observethe persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice andrats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-weekadministration period and a 4-week withdrawal period (recovery period), there were no significantdifferences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical andhematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD50) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, theno-observed-adverse-effect level for female and male SD rats was 180 mg/kg.
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Li, Chunmei,Wang, Zhezhe,Li, Guisheng,Wang, Zhenhua,Yang, Jianrong,Li, Yanshen,Wang, Hongtao,Jin, Haizhu,Qiao, Junhua,Wang, Hongbo,Tian, Jingwei,Lee, Albert W.,Gao, Yonglin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: 20(S)-ginsenoside-Rg3 (C<sub>42</sub>H<sub>72</sub>O<sub>13</sub>), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming mice and Sprague-Dawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the 26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26 weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observe the persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice and rats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-week administration period and a 4-week withdrawal period (recovery period), there were no significant differences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical and hematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD<sub>50</sub>) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no-observed-adverse-effect level for female and male SD rats was 180 mg/kg.
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