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Al-Qurashi, Faisal Othman,Aladsani, Ahmed Abdullah,Qanea, Fatema Khalil Al,Faisal, Sarah Yousef The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.4
We report a 12-month-old female infant who had a history of neonatal sepsis with liver micro-abscesses that resolved with intravenous antibiotics during neonatal period. During her neonatal admission period, no umbilical vein catheter was inserted. Also, she did not undergo any abdominal surgeries or had a postnatal history of necrotizing enterocolitis. However, the child developed upper gastrointestinal bleeding in form of hematemesis and melena secondary to esophageal varices at the age of 12 months with an extra-hepatic portal vein obstruction with cavernous transformation and portal hypertension subsequently. The child underwent a successful endoscopic injection sclerotherapy. She is now 20-month-old and has portal hypertension but otherwise asymptomatic. We are proposing the possibility of a delayed-onset portal hypertension as a complication of liver abscess and neonatal sepsis.
Faisal Othman Al-Qurashi,Ahmed Abdullah Aladsani,Fatema Khalil Al Qanea,Sarah Yousef Faisal 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.4
We report a 12-month-old female infant who had a history of neonatal sepsis with liver micro-abscesses that resolved with intravenous antibiotics during neonatal period. During her neonatal admission period, no umbilical vein catheter was inserted. Also, she did not undergo any abdominal surgeries or had a postnatal history of necrotizing enterocolitis. However, the child developed upper gastrointestinal bleeding in form of hematemesis and melena secondary to esophageal varices at the age of 12 months with an extra-hepatic portal vein obstruction with cavernous transformation and portal hypertension subsequently. The child underwent a successful endoscopic injection sclerotherapy. She is now 20-month-old and has portal hypertension but otherwise asymptomatic. We are proposing the possibility of a delayed-onset portal hypertension as a complication of liver abscess and neonatal sepsis.
( Ali Abdulnabi ),( David Whitford ),( Fathia Al Qurashi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although the co-existence of diabetes mellitus and sickle cell disease has been shown to be rare, this has not been established in a population where both conditions are highly prevalent. Both diseases lead to life threatening cardiovascular complications and their relationship might be important in the prevention of cardiovascular disease. The aim of this study was to determine the prevalence of diabetes mellitus in patients with sickle cell disease in a country with a high prevalence of both disorders. Methods: A cross sectional prevalence study in Bahrain. A random sample of 520 patients aged 18 years and over was taken from all sickle cell disease patients admitted to Salmaniya Medical Complex between 2003 to 2010 (n=2204). Patients` files and laboratory records were examined for the presence of diabetes. Data was analysed using descriptive statistics and chi-squared tests of association. Results: 376 patients were included (mean age 33.5 years). 24/376 (6.4%) patients with sickle cell disease were determined to have diabetes. 32/376 (8.5%) patients had impaired glucose tolerance. The age/sex standardized prevalence of diabetes was 8.25%. There was no association between gender of the patients (χ2=1.5, df=2, p=0.47) or number of admissions (χ2=2.2, df=2, p=0.34) and the prevalence of diabetes. Conclusions: The prevalence of diabetes in patients with sickle cell disease in Bahrain is high at 8.25% but lower than expected in this population (15.3%). Lower life expectancy is excluded as an explanation for the lower prevalence of diabetes in sickle cell disease patients by age-standardization. There may be a protective effect of sickle cell disease towards developing diabetes. However, the impact of these two conditions on vascular disease suggests a need for screening and aggressive treatment of vascular risk factors in this population.
Association of Helicobacter pylori cagA Gene with Gastric Cancer and Peptic Ulcer in Saudi Patients
( Taisir Saber ),( Mabrouk M. Ghonaim ),( Amany R. Yousef ),( Amany Khalifa ),( Hesham Al Qurashi ),( Mohammad Shaqhan ),( Mohammad Samaha ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.7
This study was conducted to assess the relationship between occurrence of gastric cancer and peptic ulcer, and the presence of H. pylori cagA gene and anti-CagA IgG, and to estimate the value of these antibodies in detecting infection by cagA gene-positive H. pylori strains in Saudi patients. The study included 180 patients who were subjected to upper gastrointestinal endoscopy in Taif province and Western region of Saudi Arabia (60 gastric cancer, 60 peptic ulcer, and 60 with non-ulcer dyspepsia). Gastric biopsy specimens were obtained and tested for H. pylori infection by rapid urease test and culture. PCR was performed on the isolated strains and biopsy specimens for detection of the cagA gene. Blood samples were collected and tested for CagA IgG by ELISA. H. pylori infection was detected among 72.8% of patients. The cagA gene and anti-CagA IgG were found in 63.4% and 61.8% of H. pylori-infected patients, respectively. They were significantly (p < 0.01) higher in patients with gastric cancer and peptic ulcer compared with those with non-ulcer dyspepsia. Detection of the CagA IgG was 91.6% sensitive, 89.6% specific, and 90.8% accurate compared with detection of the cagA gene. Its positive and negative predictive values were 93.8% and 86%, respectively. The study showed a significant association between the presence of the cagA gene and gastric cancer and peptic ulcer disease, and between anti-CagA IgG and the cagA gene in Saudi patients. However, a further larger study is required to confirm this finding.
Rachid Kellal,Driss Benmessaoud Left,Zaki S. Safi,Nuha Wazzan,Ohoud S. Al-Qurashi,Mustapha Zertoubi 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-
In this study, the efficacy of liquid waste derived from the hydrodistillation of ChrysanthemumCoronarium stems as a corrosion inhibitor for carbon steel in 1 M HCl was investigated. Phytochemicalscreening and analysis of total phenolic and flavonoid contents were conducted to determine the chemicalabundance of the extract (CCSE). An electrochemical evaluation was performed using polarizationpotentiodynamic and electrochemical impedance spectroscopy at 293 K. The results revealed that theextract effectively suppressed the corrosion of carbon steel with an inhibition efficiency of 80% througha mixed inhibition mechanism. The effect of temperature on corrosion inhibition was evaluated, and thesynergistic effect of KI in combination with the CCSE inhibitor was also studied. Surface morphologyexamination of carbon steel was conducted through SEM-EDX analysis to further examine the electrochemicalfindings and to understand the surface changes caused by the inhibitor. Additionally, computationalanalysis utilizing Density Functional Theory (DFT) and Molecular Dynamics Simulation (MD) wasconducted to gain further insight into the electronic adsorption mechanism at the active sites of the phytochemicalcompounds.