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Hossain, Md. Akil,Park, Hae-chul,Jeong, Kyunghun,Jang, Yang ho,Kim, Dae Gyun,Kang, JeongWoo,Lee, Kwang-jick Hindawi 2017 BioMed research international Vol.2017 No.-
<P>The pharmacokinetics of marbofloxacin in pigs after intravenous (i.v.), intramuscular (i.m.), and peroral (p.o.) administration and pharmacokinetic/pharmacodynamic indices of this drug against Korean local isolates of<I> Actinobacillus pleuropneumoniae</I> were determined in this study. Marbofloxacin (2.50 mg/kg of body weight) was administered, and blood samples were collected with designated time intervals. Plasma-extracted marbofloxacin was injected into the LC-MS/MS system. The in vitro and ex vivo antibacterial activities of marbofloxacin were evaluated against 20 isolates of<I> A. pleuropneumoniae</I>. The mean peak plasma concentrations (<I>C</I><SUB>max</SUB>) after i.v., i.m., and p.o administration were 2.60 ± 0.10, 2.59 ± 0.12, and 2.34 ± 0.12 <I>µ</I>g/mL at 0.25 ± 0.00, 0.44 ± 0.10, and 1.58 ± 0.40 h, respectively. The area under the plasma concentration-time curves (AUC<SUB>0–24</SUB>) and elimination half-lives were 24.80 ± 0.90, 25.80 ± 1.40, and 23.40 ± 5.00 h·<I>μ</I>g/mL and 8.60 ± 0.30, 12.80 ± 1.10, and 8.60 ± 0.00 h, for i.v., i.m., and p.o. administration, correspondingly. The AUC<SUB>0–24</SUB>/MICs of marbofloxacin after i.v., i.m., and p.o. administration were 253.86 ± 179.91, 264.1 ± 187.16, and 239.53 ± 169.75 h, respectively. The <I>C</I><SUB>max</SUB>/MIC values were 26.58 ± 18.84, 26.48 ± 18.77, and 23.94 ± 16.97, and T>MICs were 42.80 ± 1.01, 36.40 ± 1.24, and 38.60 ± 1.18 h, after i.v., i.m., and p.o. administration, respectively. Thus, marbofloxacin dosage of 2.50 mg/kg of body weight by i.v., i.m., and p.o. administration with 24 h dosing interval will provide effective treatment for the infection of pig by<I> A. pleuropneumonia</I>.</P>
Hossain, Md. Akil,Lee, Seung-Jin,Park, Na-Hye,Birhanu, Biruk Tesfaye,Mechesso, Abraham Fikru,Park, Ji-Yong,Park, Eun-Jin,Lee, Sam-Pin,Youn, Sun-Joo,Park, Seung-Chun Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>The aim of this study was to evaluate the potentials of fermented<I> Cucurbita moschata</I> extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD). Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat diet (HFD) with and without FCME. Changes in body weight gain and consumption of feed and water were recorded. Major organs, adipose tissues, and blood samples were collected after the experimental period. The serum lipid profile, histological features of liver and adipose tissues, and mRNA expression of different adipogenic/lipogenic genes from liver tissue were evaluated. The supplementation of FCME in HFD significantly prevented HFD-induced increment of bodyweight. The adipose tissue mass, liver enzymes, and plasma lipids were also reduced significantly (<I>p</I> < 0.05) by the consumption of FCME. The mRNA expressions of adipogenic/lipogenic genes (PPAR<I>γ</I>, C/EBP<I>α</I>, C/EBP<SUB><I>β</I></SUB>, C/EBP<I>γ</I>, and SREBP-1C) in FCME-treated obese mice were considerably (<I>p</I> < 0.05) suppressed. FCME showed its antiobesity potential by suppressing the body weight gain and by modulating the plasma lipids and liver enzymes through the regulation of adipogenic/lipogenic transcriptional factors. Fermented<I> Cucurbita moschata</I> could be an opportunistic agent in controlling obesity and fatty liver changes.</P>
Synergistic Effect and Antiquorum Sensing Activity of <i>Nymphaea tetragona</i> (Water Lily) Extract
Hossain, Md. Akil,Park, Ji-Yong,Kim, Jin-Yoon,Suh, Joo-Won,Park, Seung-Chun Hindawi Publishing Corporation 2014 BioMed research international Vol.2014 No.-
<P>Salmonellosis is a common and widely distributed food borne disease where <I>Salmonella typhimurium</I> is one of the most important etiologic agents. The purpose of this study was to investigate the antimicrobial activity of <I>Nymphaea tetragona</I> alone and in combination with antibiotics against <I>S. typhimurium</I>. It also aimed to assess the plant for quorum sensing inhibition (QSI) activity and to identify the bioactive compounds. The antibacterial activities of the extract were assessed using broth microdilution method. Disk agar diffusion method was employed to determine the QSI and bioactive compounds were identified by GC-MS analysis. Ethyl acetate fraction of <I>N. tetragona</I> extract (EFNTE) demonstrated good antimicrobial activity (MIC 781 <I><I>μ</I></I>g/mL) against 4 strains out of 5. FIC index ranged from 0.375 to 1.031 between EFNTE/tylosin and 0.515 to 1.250 between EFNTE/streptomycin against <I>S. typhimurium</I>. Among all extracts, EFNTE and butanol fraction more significantly inhibited pigment production of <I>C. violaceum</I>. Polyphenols were identified as major compound of EFNTE and butanol fraction. These results indicate that combination among <I>N. tetragona</I> extract and antibiotics could be useful to combat drug-resistance <I>Salmonella</I> infections and polyphenols are promising new components from <I>N. tetragona</I> that warrant further investigation as a candidate anti-<I>Salmonella</I> agent and quorum sensing inhibitor.</P>
강정우,Md Akil Hossain,박해철,김용상,이광직,박성원 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.2
It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook this study to optimize the dose of enrofl xacin against Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in chicken by assessingits pharmacokinetic/pharmacodynamic (PK/PD) indices. The antibacterial activities of enrofl xacin against S. Enteritidis were evaluated. After administering 10 mg/kg body weight (b.w.) of enrofl xacin to broiler chickens of both sexes by intravenous (IV) and peroral (PO) routes, blood samples were drawn at different intervals and enrofl xacin concentrationsin plasma were determined. PK/PD indices were calculated by integrating the PK and PD data. The elimination half-lives (T1/2), time required to reach peak concentration (Tmax), peak concentration (Cmax), and area under curve (AUC) after administering enrofl xacin by PO and IV routes were 25.84 ± 1.40 h, 0.65 ± 0.12 h, 3.82 ± 0.59 µg/mL, and 20.84 ± 5.0 µg·h/mL, and 12.84 ± 1.4 h, 0.22 ± 0.1 h, 6.74 ± 0.03 µg/mL, and 21.13 ± 0.9 µg.h/mL, respectively. The bioavailability of enrofl xacin was 98.6% ± 8.9% after PO administration. The MICs of enrofl xacin were 0.0625–1 µg/mL against S. Enteritidis strains, and the MIC50 was 0.50 µg/ mL. The Cmax/MIC50 were 7.64 ± 0.2 and 13.48 ± 0.7 and the 24 h AUC/MIC50 were 41.68 ± 0.1 and42.26 ± 0.3 after administering the drug through PO and IV routes, respectively. The data in this study indicate that the application of 50 mg/kg b.w. of enrofl xacin to chicken through PO and IV routes with a dosing interval of 24 h can effectively cure S. Enteritidis infection, indicating the need for a 5-fold increase in the recommended dosage of enrofl xacin in chicken.
Application of carbon dioxide as a novel approach to eradicate poultry red mites
Jeong-Woo Kang,Md Akil Hossain,Jiyeon Jeong,Haechul Park,Jin-Hyun Kim,Min-Su Kang,Yong-Kuk Kwon,Yong-Sang Kim,Sung-Won Park 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.2
Poultry red mites (PRMs), Dermanyssus gallinae, are one of the most harmful ectoparasites of laying hens. Because of their public health impact, safe, effective methods to eradicate PRMs are greatly needed. Carbon dioxide (CO2) was shown to eradicate phytophagous mites; however, there is no evidence that PRMs can be eradicated by CO2. Thus, the efficacy of CO2, applied by direct-spraying and dry ice-generated exposure, for eradicating PRMs was investigated. Both treatments eradicated > 85% of PRMs within 24 h and 100% of PRMs by 120 h of post-treatment. Therefore, these novel approaches may be useful for eradicating PRMs in clinical settings.
Reza, Md.Ahsanur,Hossain, Md. Akil,Lee, Seung-Jin,Yohannes, Sileshi Belew,Damte, Dereje,Rhee, Man-hee,Jo, Woo-Sik,Suh, Joo-Won,Park, Seung-Chun Begell House Inc. 2014 INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS Vol.16 No.1
<P>In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water). The DCMF was found to have more potent antitumor activity against broncheoalveolar cancer (half maximal inhibitory concentration = 57.2 ?g/mL) and gastric cancer cells (half maximal inhibitory concentration = 73.2 ?g/mL) compared to the other solvent fractions, although all fractions inhibited the proliferation of the tumor cells in a dose-dependent manner. We further analyzed the DCMF composition by gas chromatography-coupled mass spectroscopy. Based on the results of this analysis, an antitumor active component (diazane) was identified in the DCMF. However, we found that diazane alone had a lower level of antitumor activity than the DCMF. These findings indicate that other unknown components of the DCMF also are responsible for the cytotoxic effects of DCMF against tumor cells. Semiquantitative reverse transcription polymerase chain reaction analysis demonstrated that DCMF induced cytotoxicity or tumor cell apoptosis as a result of the downregulation of Bcl-2 expression and p53 overexpression. Taken together, our study results demonstrated that the DCMF may be used as a functional additive for enhancing antioxidant activities and suppressing tumor growth in the body.</P>