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Pharmacokinetics of low doses of colchicine in the leukocytes of Japanese healthy individuals
Akiko Mutoh,Hitoshi Uehara,Asano Maeda,Akihiro Tokushige,Yasushi Higashiuesato,Mika Maeda,Yuji Kumagai,Shinichiro Ueda 대한임상약리학회 2023 Translational and Clinical Pharmacology Vol.31 No.4
The venerable drug colchicine has garnered significant recent attention due to its endorsement by the United States Food and Drug Administration as an anti-inflammatory medication for cardiovascular diseases. However, the administration of this drug at its minimal available dose of 0.5 mg has been associated with certain adverse reactions. Once colchicine is administered, the drug disappears from blood in a short time and distributes in the leukocytes for a certain period of time that elicits anti-inflammatory effect. Consequently, an in-depth comprehension of the pharmacokinetics of lower dosages within leukocytes assumes important for its broader application in routine clinical contexts. In this study, we present a comprehensive analysis of the pharmacological disposition of colchicine in the plasma, polymorphonuclear leukocytes, and mononuclear leukocytes among healthy Japanese male subjects, following both single and multiple oral administrations of 0.5 mg and 0.25 mg doses of colchicine. Our investigation reveals that colchicine persists within leukocyte populations even when administered at reduced dosages. The findings herein hold promise for mitigating the adverse effects associated with its use in the treatment of inflammatory cardiovascular disorders.
X-ray Crystallographic Studies on Binding Specificity of Norovirus to Lewis Antigens
Tomomi Kubota,Akiko Kumagai,Hiromi Ito,Sanae Furukawa,Yuichi Someya,Koji Ishii,Takaji Wakita,Naokazu Takeda,Haruko Shirato,Hisashi Narimatsu 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Norovirus (NoV) is a major causative agent of nonbacterial acute, epidemic gastroenteritis, and often widespread in winter. Although most NoV infections are cured without serious symptoms, it could cause severe symptoms in elderlies and young children. The initial infection event is adhesion of NoV to glycans expressed in the epidermal cells of the small intestine. We have identified several NoV strains that show affinity to Le
Harin Cheong,Akiko Kumagai,Sehyun Oh,Sang-Seob Lee 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.4
The dental characteristics created by acquired dental treatments can be used as age estimators. This pilot study aimed to analyze the correlation between the number of teeth observed for dental characteristics and chronological age and to develop new non-invasive age estimation models. Dental features on panoramic radiographs (420 radiographs of subjects aged 20-89 years) were classified and coded. The correlation between the number of teeth for each selected code (codes V, X, T, F, P, and L) and age was observed, and multiple regression was performed to analyze the relationship between them. Eleven regression models with various combinations of dental sextants were presented. The model with the data from both sides of the posterior teeth on both jaws showed the best performance (root mean square error of 14.78 years and an adjusted R2 of 0.461). The model with all teeth was the second-best. Based on these results, we confirmed statistically significant correlations between certain dental features and chronological age. We also observed that some regression models performed sufficiently well to be used as adjunctive methods in forensic practice. These results provide valuable information for the design and performance of future full-scale studies.