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Phase Diagram and Eu Valence State in EuPtP1−xAsx
Masaki Sugishima,Akihiro Mitsuda,Hirofumi Wada,Masahiko Isobe,Yutaka Ueda 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
EuPtP is known to exhibit two valence ordering transitions, one at T1 = 235 K and the other atT2 = 190 K. For T > T1, the Eu ions are in the valence fluctuating state. For T2 < T < T1, the Euvalence state is ordered along the c-axis with the sequence of Eu2+-Eu2+-Eu3+-Eu2+-Eu2+-Eu3+. Moreover, the stacking is replaced by another sequence of Eu2+-Eu3+-Eu2+-Eu3+ at temperaturesbelow T2. The substitution of As for P expands the lattice and decreases both T1 and T2. Inthis paper, we report the magnetic susceptibility and electrical resistivity of EuPtP1−xAsx singlecrystals. We observed two valence ordering transitions for 0 ≤ x ≤ 0.4, while a single valenceordering transition was detected for 0.55 ≤ x ≤ 0.6. No valence ordering transitions were observedfor x = 0.7 down to the lowest temperature. Based on the experimental results, we present thephase diagram of EuPtP1−xAsx and discuss the Eu valence state in this system.
Bang, Wooyoung,Kim, Sewon,Ueda, Akihiro,Vikram, Meenu,Yun, Daejin,Bressan, Ray A,Hasegawa, Paul M,Bahk, Jeongdong,Koiwa, Hisashi American Society of Plant Physiologists 2006 Plant Physiology Vol.142 No.2
<P>An Arabidopsis (Arabidopsis thaliana) multigene family (predicted to be more than 20 members) encodes plant C-terminal domain (CTD) phosphatases that dephosphorylate Ser residues in tandem heptad repeat sequences of the RNA polymerase II C terminus. CTD phosphatase-like (CPL) isoforms 1 and 3 are regulators of osmotic stress and abscisic acid (ABA) signaling. Evidence presented herein indicates that CPL3 and CPL4 are homologs of a prototype CTD phosphatase, FCP1 (TFIIF-interacting CTD-phosphatase). CPL3 and CPL4 contain catalytic FCP1 homology and breast cancer 1 C terminus (BRCT) domains. Recombinant CPL3 and CPL4 interact with AtRAP74, an Arabidopsis ortholog of a FCP1-interacting TFIIF subunit. A CPL3 or CPL4 C-terminal fragment that contains the BRCT domain mediates molecular interaction with AtRAP74. Consistent with their predicted roles in transcriptional regulation, green fluorescent protein fusion proteins of CPL3, CPL4, and RAP74 all localize to the nucleus. cpl3 mutations that eliminate the BRCT or FCP1 homology domain cause ABA hyperactivation of the stress-inducible RD29a promoter, whereas RNAi suppression of CPL4 results in dwarfism and reduced seedling growth. These results indicate CPL3 and CPL4 are a paralogous pair of general transcription regulators with similar biochemical properties, but are required for the distinct developmental and environmental responses. CPL4 is necessary for normal plant growth and thus most orthologous to fungal and metazoan FCP1, whereas CPL3 is an isoform that specifically facilitates ABA signaling.</P>
A Design Strategy for the LCR Filter and Carrier Frequency in a Series Voltage Compensator
Nakata, Atsushi,Torii, Akihiro,Ueda, Akiteru The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.2
In this paper, we propose the LCR filter design method and the carrier frequency decision method in the series voltage compensator. In this proposed design method, the filter $L_f$ is calculated from the peak value of the ripple current, and the filter $C_f$ is calculated from the ripple voltage component. The damping resistance is calculated from the percentage of the elimination of the carrier frequency component and the settling time. We verify a model equipment in the experiment, and the experimental results agree well with the calculated design values.
Aoyama, Yuki,Toriumi, Kazuya,Mouri, Akihiro,Hattori, Tomoya,Ueda, Eriko,Shimato, Akane,Sakakibara, Nami,Soh, Yuka,Mamiya, Takayoshi,Nagai, Taku,Kim, Hyoung-Chun,Hiramatsu, Masayuki,Nabeshima, Toshitak American College of Neuropsychopharmacology 2016 Neuropsychopharmacology Vol.41 No.2
<P>Cigarette smoking during pregnancy is associated with various disabilities in the offspring such as attention deficit/hyperactivity disorder, learning disabilities, and persistent anxiety. We have reported that nicotine exposure in female mice during pregnancy, in particular from embryonic day 14 (E14) to postnatal day 0 (P0), induces long-lasting behavioral deficits in offspring. However, the mechanism by which prenatal nicotine exposure (PNE) affects neurodevelopment, resulting in behavioral deficits, has remained unclear. Here, we report that PNE disrupted the proliferation of neuronal progenitors, leading to a decrease in the progenitor pool in the ventricular and subventricular zones. In addition, using a cumulative 5-bromo-2'-deoxyuridine labeling assay, we evaluated the rate of cell cycle progression causing the impairment of neuronal progenitor proliferation, and uncovered anomalous cell cycle kinetics in mice with PNE. Accordingly, the density of glutamatergic neurons in the medial prefrontal cortex (medial PFC) was reduced, implying glutamatergic dysregulation. Mice with PNE exhibited behavioral impairments in attentional function and behavioral flexibility in adulthood, and the deficits were ameliorated by microinjection of D-cycloserine into the PFC. Collectively, our findings suggest that PNE affects the proliferation and maturation of progenitor cells to glutamatergic neuron during neurodevelopment in the medial PFC, which may be associated with cognitive deficits in the offspring.</P>
Hisashi Koiwa,,Stephane Hausmann,Bang, Woo-Young,Akihiro Ueda,Naoko Kondo,Akihiro Hiraguri,Toshiyuki Fuku,hara,Bahk, Jeong-Dong,Yun, Dae-Jin,Ray A. Bressan,Paul M. Hasegawa,Stewart Shuman Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
Transcription and mRNA processing are regulated by phosphorylation and dephosphorylation of the C-terminal domain (CTD) of RNA polymerase Ⅱ, which consists of tandem repeats of a Y^(1)S^(2)P^(3)T^(4)S^(5)P^(6)S^(7) heptapeptide. Previous studies showed that members of the plant CTD phosphatase-like (CPL) protein family differentially regulate osmotic stress-responsive and abscisic acid-responsive transcription in Arabidopsis thaliana. Here we report that AtCPL1 and AtCPL2 specifically dephosphorylate Ser-5 of the CTD heptad in Arabidopsis RNA polymerase Ⅱ, but not Ser-2. An N-terminal catalytic domain of CPL1, which suffices for CTD Ser-5 phosphatase activity in virto, includes a signature DXDXT acylphosphatase motif, but lacks a breast cancer 1 CTD, which is an essential component of the fungal and metazoan Fcp1 CTD phosphatase enzymes. The CTD of CPL1, which contains two putative double-stranded RNA binding motifs, is essential for the in vivo function of CPL1 and includes a C-terminal 23-aa signal responsible for its nuclear targeting. CPL2 has a similar domain structure but contains only one double-stranded RNA binding motif. Combining mutant alleles of CPL1 and CPL2 causes synthetic lethality of the male but not the female gametes. These results indicate that CPL1 and CPL2 exemplify a unique family of CTD Ser-5-specific phosphatases with an essential role in plant growth and development.
Pharmacokinetics of low doses of colchicine in the leukocytes of Japanese healthy individuals
Akiko Mutoh,Hitoshi Uehara,Asano Maeda,Akihiro Tokushige,Yasushi Higashiuesato,Mika Maeda,Yuji Kumagai,Shinichiro Ueda 대한임상약리학회 2023 Translational and Clinical Pharmacology Vol.31 No.4
The venerable drug colchicine has garnered significant recent attention due to its endorsement by the United States Food and Drug Administration as an anti-inflammatory medication for cardiovascular diseases. However, the administration of this drug at its minimal available dose of 0.5 mg has been associated with certain adverse reactions. Once colchicine is administered, the drug disappears from blood in a short time and distributes in the leukocytes for a certain period of time that elicits anti-inflammatory effect. Consequently, an in-depth comprehension of the pharmacokinetics of lower dosages within leukocytes assumes important for its broader application in routine clinical contexts. In this study, we present a comprehensive analysis of the pharmacological disposition of colchicine in the plasma, polymorphonuclear leukocytes, and mononuclear leukocytes among healthy Japanese male subjects, following both single and multiple oral administrations of 0.5 mg and 0.25 mg doses of colchicine. Our investigation reveals that colchicine persists within leukocyte populations even when administered at reduced dosages. The findings herein hold promise for mitigating the adverse effects associated with its use in the treatment of inflammatory cardiovascular disorders.