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RISS 인기검색어
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- 저자 : Ajay Saini (검색결과 4 건)
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( Ajay Duseja ),( Kiran K Thumburu ),( Nitin Saini ),( Ashim DAS ),( RK Dhiman ),( YK Chanwla ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Experimental data suggests role of adipokine leptin in hepatic fibrosis. Human data on this issue is controversial. Aim of this study was to measure serum leptin levels in patients with nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) and correlate its levels with hepatic fibrosis. Methods: serum leptin levels were assessed by ELISA (DRG Diagnostics, Germany) in 40 patients with NAFLD (liver biopsy=29)(mean age 39.8±10.8 years, men 29), 23 patients with CHC (liver biopsy=20) (mean age 37.7±6.7, men 22) and 15 healthy controls (normal BMI, LFT and ultrasound abdomen), (mean age 32.2±9.2 years, men 13). Histological analysis was done as per Matteoni et al (Gastroenterology 1999) and Brunt et al (Am J Gastroenterol 1999) in patients with NAFLD and as per Ishak et al (J Hepatol. 1995) in patients with CHC. Correlation of serum leptin was studied with age, gender, BMI, waist, waist-hip ratio, ALT, insulin resistance, class of NAFLD (NASH vs. no NASH) and hepatic necro-inflammation and fibrosis. Results: Patients with CHC had higher serum leptin levels in comparison to healthy controls (12.6±3.4 ng/ml vs. 5.0±5.2 ng/ml, p=0.002) and NAFLD patients (12.6±3.4 ng/ml vs. 5.9±3.3 ng/ml, p=0.05). There was no difference between serum leptin levels of NAFLD patients and healthy controls. Serum leptin showed no correlation with age, gender, BMI, waist, waist hip ratio, ALT and insulin resistance in both the patient groups. There was no correlation of serum leptin with either class of NAFLD (NASH vs. no NASH) (p=0.75) and with grade of the disease and stage of hepatic fibrosis in both NAFLD (p=0.44) and CHC groups (p=0.59). Conclusions: Patients with CHC have higher serum leptin levels in comparison to NAFLD. Serum leptin levels do not correlate with hepatic fibrosis in patients with NAFLD and CHC.
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Gaurav Gupta,Ajay Shahbaj,Dharmendra Kumar Pipal,Pawan Saini,Vijay Verma,Sangeeta Gupt,Vibha Rani,Seema Yadav 대한내시경로봇외과학회 2022 Journal of Minimally Invasive Surgery Vol.25 No.4
Purpose: Uncertainty exists about whether early laparoscopic cholecystectomy (LC) is an appropriate surgical treatment for acute calculous cholecystitis. This study aimed to compare early vs. late LC for acute calculous cholecystitis regarding intraoperative difficulty and postoperative outcomes. Methods: This was a prospective randomized study carried out between December 2015 and June 2017; 60 patients with acute calculous cholecystitis were divided into two groups (early and delayed groups), each comprising 30 patients. Thirty patients treated with LC within 3 to 5 days of arrival at the hospital were assigned to the early group. The other 30 patients were placed in the delayed group, first treated conservatively, and followed by LC 3 to 6 weeks later. Results: The conversion rates in both groups were 6.7% and 0%, respectively (p = 0.143). The operating time was 56.67 ± 11.70 minutes in the early group and 75.67 ± 20.52 minutes in the delayed group (p = 0.001), and both groups observed equal levels of postoperative complications. Early LC patients, on the other hand, required much fewer postoperative hospital stay (3.40 ± 1.99 vs. 6.27 ± 2.90 days, p = 0.006). Conclusion: Considering shorter operative time and hospital stay without significant increase of open conversion rates, early LC might have benefits over late LC.
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( Neelam V. Ramana Reddy ),( Mukesh Kumar Saini ),( Pera Jayavardhan Reddy ),( Ajay Singh Thakur ),( Challa Dinesh Reddy ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-
Objective: Knee arthritis associated with tibial stress fractures represents an uncommon and difficult clinical scenario to treat. The use of long, fluted tibial extension rods has been vital in the management of such cases owing to immediate fracture stability and single-stage surgery without the need to open the fracture site. This study investigates clinical and radiological outcomes following total knee arthroplasty using a tibial extension stem in cases of knee osteoarthritis with tibial stress fracture. Methods: From February 2015 to December 2020, 17 patients who had total knee arthroplasty implanted with a long stemmed tibial component were included in the study. Patient data were analyzed for knee range of motion, deformities, Knee Society score, knee function score, and time to fracture union in the pre- and postoperative periods. Results: The mean follow-up duration was 22.7 ± 11.68 months (range 12-60 months), and mean time to fracture healing was 10.23 ± 2.81 weeks (range 8-20 weeks). The preoperative mean fixed flexion deformity improved from 8.53 ± 3.43° to a mean of 0.29°, and knee flexion improved from 79.4 ± 13.90° to 125.29 ± 8.74° on postoperative assessment. The Knee Society score improved from a mean preoperative score of 18.94 ± 5.55 (range 8-28) to 89.41 ± 7.5 (range 74-102, p value < 0.001). Similarly, the knee function score improved significantly from a mean preoperative score of 15.5 ± 4.48 (range 8-26) to a mean of 85 ± 6.09 (range 72-94, p value < 0.001). Conclusion: Total knee arthroplasty using long tibial extenders has been an effective and safe surgical option for patients with advanced osteoarthritis with tibial stress fractures.
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Gautam Vishwakarma,Ravi Prakash Sanyal,Abhijit Shitre,D. A. Gadekar,Ajay Saini,Bikram Kishore Das 한국작물학회 2019 Journal of crop science and biotechnology Vol.22 No.4
Stem rust resistance gene Sr2 is an important slow-rusting gene which has provided resistance against stem rust for many years. The Sr2 gene has durable resistance against all stem rust pathogens including the Ug99 group of races. It shows recessive inheritance and is linked with two phenotypic markers, Pseudo Black Chaff (PBC) and High Temperature-Induced Seedling Chlorosis (HTISC). However, direct screening as well as phenotypic marker-based screening for selection of Sr2 is difficult due to the effect of environmental factors and genetic background. Microsatellite marker Xgwm533 linked to Sr2 gene is useful for rapid screening of large populations. Here we report validation and use of Xgwm533 for screening 21 wheat lines and 24 wheat genotypes for the presence of the Sr2 gene. Furthermore, we also report the presence of a new, smaller allele (97 bp) of Xgwm533 locus in a few genotypes that was also confirmed by sequencing. We also demonstrate a new SYBR green dye, melt-curve/profile-based assay for convenient screening of the Xgwm533 locus, where the presence of different alleles can be differentiated in a gel-free manner.
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