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- 검색키워드
- 저자 : Ai-Hua Liang (검색결과 9 건)
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Liang, Zhong-Guo,Zhu, Xiao-Dong,Tan, Ai-Hua,Jiang, Yan-Ming,Qu, Song,Su, Fang,Xu, Guo-Zeng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.
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Liu, Ai-Na,Sun, Ping,Liu, Jian-Nan,Ma, Jin-Bo,Qu, Hua-Jun,Zhu, Hua,Yu, Cai-Yan,Zhang, Liang-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Objective: To study the relationship between clinical pathologic characteristics, treatment modalities and prognostic factors in HER-2 (Human Epidermal growth factor Receptor-2) overexpressed breast carcinoma. Materials and Methods: Major clinico-pathological factors including therapeutic modalities and survival status of 371 breast cancer patients with HER2 over-expression, teated at Yantai Yuhuangding Hospital from March of 2002 to December of 2010 were retrospectively studied, with special attention focused on survival-related factors. Results: The median age of the total 371 patients in this study was 48 years at time of diagnosis, among which, the leading pathological type was infiltrating ductal carcinoma (92.5%); 62.8% presented with a primary tomor larger than 2 cm in diameter at diagnosis, 51.0% had axillary lymph node (ALN) metastases; ER (Estrogen receptor)/PR (Progesterone receptor) double negative occured in 52.8% of cases, and PCNA (proliferation cell nuclear antigen) (+++) was found in 55.1%. HER-2 overexpressed patients were usually in advanced stage when the diagnosis was made (72.8% at stages IIA~IIIC). The prognosis and survival were assessed in 259 patients with complete follow-up data. 5-year DFS (disease-free survival) and OS (overall survival) rate was 68.0% and 78.0% respectively. Univariate analysis revealed that age, tumor size, ALN metastases, LVSI (lymph-vascular space involvement), PCNA status, hormonal therapy, chemotherapy cycles, and HER-2 overexpression, correlated closely with the prognosis. ALN metastases, LVSI, PCNA status and chemotherapy cycles were independent predictors of survival. Conclusions: HER-2 overexpressed breast cancer has special clinical and pathological characteristics, with advanced clinical stages and high rate of ER/PR double negative. Lymph node metastases, LVSI, PCNA and chemotherapy cycles are independent predictors of prognosis.
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Shuai Wu,Ai-jun Gao,Liang-hua Xu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6
The effect of in situ thermal stretching during oxidative stabilization on the orientation of cyclized ladder structure was investigated. Based on the structure evolution of PAN fibers with the increasing stabilization temperatures, the stabilization process was classified into three different stages, namely before the onset of cyclization, during cyclization in amorphous region, and during cyclization in crystalline region. The polyacrylonitrile (PAN) precursor fibers were stretched at the three stages with stretching ratios from 0 % to 8 % during continuous stabilization process. The results show that the orientation degree of cyclized ladder structure increases with the increase of stretching ratio at the three stages and the maximum orientation efficiency of cyclized ladder structure is obtained when PAN fibers are stretched at the stage of during cyclization in crystalline region. The orientation of resulting carbon fibers strongly depends on the orientation degree of cyclized ladder structure. The orientation efficiency of turbostratic graphite crystallite also agrees well with that of cyclized ladder structure. Meanwhile, the orientation efficiency of turbostratic graphite crystallite is higher than that of cyclized ladder structure and the difference values between orientation efficiency of the two structures decrease firstly then increase with the increase of degree of cyclization.
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Lili Wei,Chenggang Xu,Ai-Hua Liang,Yuejun Fu 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.4
Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) is a kind of potential biological insecticide. Ac-PK2 protein encoded by orf123 in AcMNPV genome can inhibit eIF2α family kinases to increase viral adaptation in vivo. In our previous study, it was found that recombinant AcMNPV-PK2-EGFP showed high virulence and anti-insect activity against Sf9 cells and Spodoptera exigua larvae. In this study, we investigated the function of Ac-PK2 protein in the insecticidal activity of AcMNPV and the anti-insect mechanism. AcMNPV-PK2- EGFP up-regulated the expression of Ac-pk2 gene in midgut and nerve cord in infected Spodoptera exigua larvae, compared with these in wild-type treatment group. Transcriptional level of BmK IT and detoxication related genes in epidermis, midgut and nerve cord was detected by quantitative PCR. Phenoloxidase activity assay showed that the insect’s humoral immunity was affected by AcMNPV-PK2-EGFP in a time-effect relationship. Western blot analysis of P53 protein indicated the apoptotic level in the midgut tissue was higher in AcMNPV-BmK IT and AcMNPV-PK2-EGFP co-infeced Spodoptera exigua larvae than that in other treatment groups at 4 h and 8 h postinfection. These results provided a theoretical basis to study the application of AcMNPV-PK2-EGFP as a biological insecticide.
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Bao-yong Lai,Li-yan Jia,Bo-Wen Yu,Shi-Bing Liang,Ai-Jing Chu,Hui-juan Cao,Jian-ping Liu,Xiao-Hua Pei 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.
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eRF1aMC and Mg2+ Dependent Structure Switch of GTP Binding to eRF3 in Euplotes octocarinatus
( Song Li ),( Yu Xin Jia ),( Wen Si Zhu ),( Bao Feng Chai ),( Ai Hua Liang ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.2
Eukaryotic translation termination is governed by eRF1 and eRF3. eRF1 recognizes the stop codons and then hydrolyzes peptidyl-tRNA. eRF3, which facilitates the termination process, belongs to the GTPase superfamily. In this study, the effect of the MC domain of eRF1a (eRF1aMC) on the GTPase activity of eRF3 was analyzed using fluorescence spectra and high-performance liquid chromatography. The results indicated eRF1aMC promotes the GTPase activity of eRF3, which is similar to the role of eRF1a. Furthermore, the increased affinity of eRF3 for GTP induced by eRF1aMC was dependent on the concentration of Mg2+. Changes in the secondary structure of eRF3C after binding GTP/GDP were detected by CD spectroscopy. The results revealed changes of conformation during formation of the eRF3C·GTP complex that were detected in the presence of eRF1a or eRF1aMC. The conformations of the eRF3C·eRF1a·GTP and eRF3C·eRF1aMC·GTP complexes were further altered upon the addition of Mg2+. By contrast, there was no change in the conformation of GTP bound to free eRF3C or the eRF3C·eRF1aN complex. These results suggest that alterations in the conformation of GTP bound to eRF3 is dependent on eRF1a and Mg2+, whereas the MC domain of eRF1a is responsible for the change in the conformation of GTP bound to eRF3 in Euplotes octocarinatus.
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Yu Wang,Tao Yan,Shuai Wu,Yuan-jian Tong,Ai-jun Gao,Liang-hua Xu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.4
In a high-temperature environment, polyacrylonitrile-based carbon fiber (PAN-CF) can be deformed by stretching, where the stretching deformation ability of PAN-CF is enhanced with the increase of the temperature. Further, the hightemperature stretching deformation of PAN-CF directly affects the control of the carbon crystalline orientation. Based on the techniques of high-resolution transmission electron microscopy (HRTEM), Raman spectroscopy, X-ray diffraction and in situ tension testing, the variation regularity and the intrinsic mechanism of high-temperature stretching deformation ability of PAN-CF obtained at different preparation temperatures were systematically studied in a high-temperature environment. The results indicated that the essence of PAN-CF high-temperature deformation was the relative motion of the carbon crystallite. Further, the main structural parameters that affected the high-temperature stretching deformation ability of PAN-CF were the degree of cross-linking between the carbon crystallites, the orientation angle(OA) of the carbon crystallite and the nitrogen content. When the testing temperature was lower than the preparation temperature, only physical structure changes were observed in the PAN-CF. For the PAN-CF tested undergoing physical structure changes, as the degree of cross-linking between the crystallites and the orientation angle decreased, the slipping of crystallites became easier. In the same environment, as the stretching tension decreased, the stretching deformation ability improved. When PAN-CF was tested under temperatures higher than the preparation temperature, the microcrystalline cross-linking in the PAN-CF was prone to fracture and slipping, and the high-temperature stretching deformation ability was enhanced. Also, for PAN-CF of lower preparation temperatures in PAN-CF containing no nitrogen (i.e., <0.15 wt%), the cross-linkages increased and the structures were more unstable, inducing an increase in the fracture of weak bonds and a reduction of the stretching tension. For nitrogen-containing PAN-CF, the removal of nitrogen led to severe shrinkage in the graphite layer and interlayer, and the fiber tension was thus increased, causing the high-temperature stretching deformation ability of the PAN-CF with less nitrogen content to be improved.
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Functional Study of Active Residues Scorpion Insect Toxin BmK IT from Buthus martensii Karsch
Yuejun Fu,Renjia Yang,Wujian Chen,Zhiyi Wu,Ai-Hua Liang,Fengyun Hu 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.2
Chinese scorpion Buthus martensii Karsch(BmK) venom is a rich source of neurotoxins which bindto various ion channels with high affinity and specificityand thus widely used as compounds to modulate channelgating. An excitatory insect toxin, BmK IT, is not conservedwith a glutamate residue at the preceding position of thethird Cys residue, and is a toxin with a non-glutamateresidue at the relevant position in the excitatory scorpion β-toxin subfamily. In this study, the mutants of recombinantBmK IT (BmK IT (I25E), BmK IT (E15G), BmK IT Cterminal(TKSYCDVQIN) truncated) were achieved bysite-directed mutagenesis. Biological activity of BmK ITand its mutants confirmed these residues or peptides playedkey roles in BmK IT. BmK IT (I25E) could increase thesensitivity of BmK IT, but BmK IT(E15G) could decreasethe sensitivity of BmK IT on Sf9 cells. BmK IT truncatedC-terminal hydrophobic amino acids could cross thespecies boundaries and was effective on mammalian C6cells. To date, several excitatory insect toxins have beenisolated and identified from the venom of Buthus martensiiKarsch. However, no functional data are available andtherefore its classification in the family of excitatory insecttoxins remains putative and is just based on its highsimilarity with the other toxins of this family. These resultsverified I25, E15 and C-terminal (TKSYCDVQIN) inBmK IT played key roles in the interaction of the BmK ITand its receptor- sodium channels on the surface of insectcells and laid a foundation for further structural andfunctional analysis of BmK IT.
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