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      • KCI등재

        Removal of sulphate from landfill leachate by crystallization

        Ahmet Aygun,Selim Dogan,Mehmet Emin Argun,Havva Ates 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.1

        The present study explores the applicability of response surface methodology (RSM) in conjunction with central composite design (CCD) matrix to statistically optimize ettringite crystallization process for the removal of sulphate from landfill leachate. A three factor-five coded level CCD with 20 runs, was performed to estimate the best fitted model. The RSM results indicated that the fitted quadratic regression model could be appropriate to predict sulfate removal efficiency. The pH was identified as the most dominant parameter affecting sulphate removal. 61.6% of maximum sulphate removal efficiency was obtained at pH of 11.06 for a 1.87 of Ca/SO₄ and 0.51 of Al/SO₄ molar ratios. The operating cost for ettringite crystallization at optimized conditions was calculated to be 0.52 $/m³. The significance of independent variables and their interactions were tested by analysis of variance. Scanning electron microscope (SEM) and SEM coupled with energy dispersive X-Ray spectroscopy results confirmed the formation of ettringite crystal and were used to describe its morphology features.

      • Relationship Between Antimetabolite Toxicity and Pharmacogenetics in Turkish Cancer Patients

        Dogan, Mutlu,Karabulut, Halil G.,Tukun, Ajlan,Demirkazik, Ahmet,Utkan, Gungor,Yalcin, Bulent,Dincol, Dilek,Akbulut, Hakan,Icli, Fikri Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

        Introduction: Antimetabolites may cause severe toxicity and even toxic death in cancer patients. Our aim was to evaluate the relationship between antimetabolite toxicity and pharmacogenetics in patients with severe clinical toxicity or alanine transaminase (ALT) elevation after fluorouracil (5FU), capecitabine or methotrexate administration. Patients and Methods: Cancer patients with severe antimetabolite toxicity were evaluated for methylenetetrahydrofolate reductase (MTHFR) gene C667T, thymidilate synthase (TS) gene 5´UTR variable number of tandem repeats (VNTR), dihydroprymidine dehydrogenase (DPYD) gene IVS14+1G/A, Xeroderma pigmentosum (XPD) gene Lys751Gln and X-ray repair cross-complementing group 1 (XRCC1) gene Arg399Gln polymorphisms. Results: Eighteen patients were enrolled, with a male/female ratio of 0.8. They had osteosarcoma in methotrexate group (n=7), gastrointestinal malignancies in 5FU group (n=9) and breast cancer in the capecitabine group (n=2). Mucositis and dermatitis occurred in all groups, together with ALT elevation in the methotrexate group and 2 toxic deaths were encountered. DPYD, TS, MTHFR, XPD and XRCC1 gene polymorphism rare allele frequencies were observed to be higher than in the general population. Conclusion: Pharmacogenetics might contribute to tailored therapy.

      • Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey

        Can, Alper,Dogan, Erkan,Bayoglu, Ibrahim Vedat,Tatli, Ali Murat,Besiroglu, Mehmet,Kocer, Murat,Dulger, Ahmet Cumhur,Uyeturk, Ummugul,Kivrak, Derya,Orakci, Zuat,Bal, Oznur,Kacan, Turgut,Olmez, Sehmus,T Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

        Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male:female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.

      • KCI등재

        Changes in the Total Lipid, Neutral Lipid, Phospholipid and Fatty Acid Composition of Phospholipid Fractions during Pastırma Processing, a Dry-Cured Meat Product

        Muhammet Irfan Aksu,Mehmet Dogan,Ahmet Necdet Sirkecioglu 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.1

        Pastırma is a dry-cured meat product, produced from whole beef or water buffalo muscles. This study was carried out to investigate the effect of production stages (raw meat, after curing, after 2nd drying and pastırma) on the total lipid, neutral lipid, phospholipid and fatty acid composition of phospholipid fraction of pastırma produced from beef M. Longissimus dorsi muscles. The pH and colour (L*, a* and b*) analyses were also performed in raw meat and pastırma. It was found that pastırma production stages had significant effects (p

      • SCOPUSKCI등재

        Acute Pancreatitis and Gastroduodenal Intussusception Induced by an Underlying Gastric Gastrointestinal Stromal Tumor: A Case Report

        Yildiz, Mehmet Siddik,Dogan, Ahmet,Koparan, Ibrahim Halil,Adin, Mehmet Emin The Korean Gastric Cancer Association 2016 Journal of gastric cancer Vol.16 No.1

        Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal system and comprise only 1% to 3% of all gastrointestinal tract tumors, with the majority of them arising in the stomach. In this report, we present the unique findings of a case of gastroduodenal intussusception caused by an underlying gastric GIST and complicated with severe acute pancreatitis.

      • Lack of Relation of Survivin Gene Expression with Survival and Surgical Prognostic Factors in Endometrial Carcinoma Patients

        Aksoy, Rifat Taner,Thran, Ahmet Taner,Boran, Nurettin,Tokmak, Aytekin,Isikdogan, Betul Zuhal,Dogan, Mehmet,Thlunay, Hakki Gokhan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

        Background: The relation ofsurvivin gene expression to survival and surgical prognostic factors in the patients with endometrial carcinoma is unclear. Materials and Methods: In this study, 62 cases who were operated due to endometrial carcinoma were investigated between 2003 and 2011 in the the gynecological oncology clinic of Female Disease Training and Investigation Hospital of Etlik Zubeyde, Hanim, Turkey. Clinical and surgical prognostic factors were investigated by screening the records of these cases. With the standard streptavidin-biotin immune peroxidase method, cytoplasmic and nuclear expression of survivin was investigated in sections with specific antibodies (1:100, diagnostic Bio Systems, USA) primer. The aim was to elucidate any relation between survivin expression and defined prognostic factors and survival. Results: There was no statistically significant relationship between cytoplasmic and nuclear indexes identified for survivin and age, body mass index, the levels of preoperative hemoglobin, platelet and Ca 125, stage, grade, lymph node meastasis, the number of meta statical lymph nodes (total, paraaortic and pelvic), myometrial invasion, serosal invasion, adnexal involvement, the presence of acid in the first diagnosis, the involvement of omentum, the adjuvant treatment application of the cases, the presence of recurrence and rate of mortality (p>0.05). Statistical significance was noted for the presence of advanced stage lymph node metastasis (pelvic, paraaortic, pelvic and paraaortic), serosal involvement, positive cytology, lymph vascular space invasion, intra abdominal metastasis, and omentum involvement. When investigated the relation between cytoplasmic and nuclear survivin indexes and total survival, the result was not statistically significant (p>0.05). Conclusions: In our study, there was no statistically significant relationship between the rates of cytoplasmic and nuclear survivin expression with identified prognostic factors and total or non-disease survival.

      • KCI등재

        One-step versus two-step dolomite calcitization (dedolomitization): differences and inferences

        Omar A. Radwan,Ahmet U. Dogan,Mohamed A. Morsy,Michael A. Kaminski,John D. Humphrey,Eric H. Christiansen 한국지질과학협의회 2021 Geosciences Journal Vol.25 No.4

        Polycrystalline calcite pseudomorphs after dolomite can exhibit mosaic or drusy fabric caused by replacement of the dolomite by calcite (one-step dedolomitization) or dolomite dissolution followed by calcite cementation (two-step dedolomitization), respectively. This study discusses the differences between the two types and interprets the characteristics of the fluid causing them. Conclusions drawn here are founded on a microscopic and petrophysical examination of an outcrop of Tuwaiq Mountain Formation, central Arabian Peninsula. Petrographic examination shows that dedolomite has distinct microfabrics in each part of the section. The lower part of the section is not affected by dolomite calcitization, the middle part is dominated by replacement fabrics, and the upper part is dominated by dissolution and/or cementation fabrics. Petrophysical examination shows a wider range of porosity and permeability values for the upper part of the section, relative to the middle and lower parts. One-step dedolomitization is characterized by preservation of the external morphology of the parent dolomite, confinement to the volume previously occupied by the dolomite, development of intracrystalline porosity and permeability that allows the fluid to maintain contact with the reaction front, and no significant effect on porosity of the original rock. Two-step dedolomitization is characterized by corrosion of the external morphology of the parent dolomite, association with other forms of calcite cementation, development without intracrystalline porosity and permeability, and positive or negative effects on the porosity. While one-step dedolomitization appears to occur within a stagnant zone of fluid circulation, the two-step dedolomitization is considered to reflect an active fluid-flow system.

      • KCI등재

        Acute Pancreatitis and Gastroduodenal Intussusception Induced by an Underlying Gastric Gastrointestinal Stromal Tumor: A Case Report

        Mehmet Siddik Yildiz,Mehmet Emin Adin,Ahmet Dogan,Ibrahim Halil Koparan 대한위암학회 2016 Journal of gastric cancer Vol.16 No.1

        Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal system and comprise only 1% to 3% of all gastrointestinal tract tumors, with the majority of them arising in the stomach. In this report, we present the unique findings of a case of gastroduodenal intussusception caused by an underlying gastric GIST and complicated with severe acute pancreatitis.

      • SCIESCOPUSKCI등재

        Design of Self-Starting Hybrid Axial Flux Permanent Magnet Synchronous Motor Connected Directly to Line

        Eker, Mustafa,Akar, Mehmet,Emeksiz, Cem,Dogan, Zafer,Fenercioglu, Ahmet The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.5

        In view of the current state of the reserves of electric energy generated resources and the share of electric motors in electricity consumption, many researches and studies related to efficiency in electric motors are being made. The presented work is related to the Axial Flux Permanent Magnet Synchronous Motor (AF-PMSM), which has recently undergone significant work based on the development of magnet and motor technology. In this study, a novel AF-PMSM was designed analytically through Finite Element Method (FEM) which can be started by connecting to a line such as an asynchronous motor in a transient state and can operate with high efficiency and power factor after synchronization in steady state without the need for an expensive motor drive. According to the obtained FEM results, a design with an efficiency class of IE4 of 5.5 kW shaft power, a 4 poles motor was obtained. As a result, economic calculations indicate that the extra cost of the designed Line start AF-PMSM with respect to the asynchronous motor is rapidly compensated by energy saving due to a more efficient operation, especially constant speed operations. As a result of the analysis obtained, the targeted values are reached. For induction motors and radial flux permanent magnet synchronous motors, a good alternative motor that can operate with high efficiency and power factor has been obtained.

      • KCI등재

        Design of Self-Starting Hybrid Axial Flux Permanent Magnet Synchronous Motor Connected Directly to Line

        Mustafa Eker,Mehmet Akar,Cem Emeksiz,Zafer Dogan,Ahmet Fenercioglu 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.5

        In view of the current state of the reserves of electric energy generated resources and the share of electric motors in electricity consumption, many researches and studies related to efficiency in electric motors are being made. The presented work is related to the Axial Flux Permanent Magnet Synchronous Motor (AF-PMSM), which has recently undergone significant work based on the development of magnet and motor technology. In this study, a novel AF-PMSM was designed analytically through Finite Element Method (FEM) which can be started by connecting to a line such as an asynchronous motor in a transient state and can operate with high efficiency and power factor after synchronization in steady state without the need for an expensive motor drive. According to the obtained FEM results, a design with an efficiency class of IE4 of 5.5 kW shaft power, a 4 poles motor was obtained. As a result, economic calculations indicate that the extra cost of the designed Line start AF-PMSM with respect to the asynchronous motor is rapidly compensated by energy saving due to a more efficient operation, especially constant speed operations. As a result of the analysis obtained, the targeted values are reached. For induction motors and radial flux permanent magnet synchronous motors, a good alternative motor that can operate with high efficiency and power factor has been obtained.

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