Green tea ameliorates the side effects of the silver nanoparticles treatment of Ehrlich ascites tumor in mice

Ahmed Magdy,Emad Sadaka,Nemany Hanafy,Mohammed A. El‑Magd,Nasr Allahloubi,Maged El Kemary 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Silver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert oxidative stress-based adverse effects on normal cells and so their applications have raised concern about possible health and environmental risks. Objective We evaluated whether green tea extract (GTE), which contains potent antioxidants, could ameliorate AgNPs geno-, cyto-, and histotoxicities without decreasing their therapeutic potential against Ehrlich ascetic carcinoma (EAC). Results GTE enhanced the anti-cancer effect of AgNPs against EAC cells and ameliorated the genotoxic effect of AgNPs as indicated by lowering chromosomal aberrations and micronucleus frequencies. Additionally, GTE relieved most of degenerative histological changes induced by AgNPs. GTE restored the increased MDA and the decreased SOD, GPx and CAT serum levels induced by AgNPs to levels comparable to normal. The pre-treatment with GTE and AgNPs showed better improvement than the post-treatment strategy. Conclusions GTE can not only ameliorate AgNPs-induced adverse effects but also improve their anti-cancer effect against EAC. So, it could be useful in the treatment of liver dysfunction associated with AgNPs.

Radiographic Position of the Electrode as a Predictor of the Outcome of InterStim Therapy

Abdullah Ahmed Gahzi,Mai Ahmed Banakhar,Dean S. Elterman,Magdy Hassouna 대한배뇨장애요실금학회 2017 International Neurourology Journal Vol.21 No.4

Purpose: Sacral neuromodulation (SNM) therapy is indicated for some refractory urological conditions. The electrode lead position in sacral x-rays during routine follow-up may predict the outcome of SNM therapy. To determine whether the radiographic position of the electrode in the sacral foramen predicted the long-term outcome of SNM therapy. Methods: This was a retrospective study of patients who underwent InterStim SNM at Toronto Western Hospital by 2 surgeons from July 2013 to March 2014. The position of electrodes in relation to the sacral bone was assessed on follow-up sacral x-rays. In the lateral view, we determined the location of the radio-opaque marker of the electrode relative to the inner surface of the sacrum (P3, D3, P2, D2, P1, D1, P0, and D0). In the anteroposterior view, the angle between a line through the spinous process shadow and the electrode was measured (0°–30°, 30°–60°, 60°–90°, >90°, or medial). Dissatisfied patients were defined as those who did not improve based on a voiding diary or those who needed salvage treatment after SNM. The primary endpoint was to determine whether the electrode lead position on sacral x-rays predicted the outcome of SNM therapy. Results: A total of 69 patients (61 female and 8 male patients) were included, with a median age of 55 years. Forty-two of the patients (60.9%) had refractory overactive bladder, 21 (30.4%) suffered from chronic urinary retention, and 6 (8.7%) had lower urinary tract symptoms and chronic pelvic pain syndrome. The univariate analysis did not show any correlation between SNM response and the electrode position or angle. Dummy regression analysis using response to implantation as the dependent outcome variable did not show any significance for any of the predictors. Conclusions: Our study did not show a correlation between the long-term response to SNM and the electrode position on follow-up sacral x-rays. In this study, electrode lead position in sacral x-ray at follow-up was not correlated with the outcome of SNM therapy.

CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin’s lymphoma

Magdy Bedewy,Shereen El-Maghraby,Ahmed Bedewy 대한혈액학회 2013 Blood Research Vol.48 No.2

Background Advances in the understanding of Hodgkin’s lymphoma (HL) show various functions of infiltrating immune cells and cytokines in relation to clinical outcomes. The expression of CD163 and c-Met has been suggested to have a role in lymphoid malignancy. Thus, we evaluated the expressions of CD163, c-Met, and serum free light chain (sFLC) in relation to the clinicopathological features of patients with advanced classical HL (cHL). Methods We assessed the expression of CD163 and c-Met in 34 patients with cHL through immunohistochemistry on the lymph node biopsy sections and the levels of pretreatment sFLC were estimated using ELISA. Results High CD163 expression correlated with increased age, B symptoms, International Prognostic Score (IPS) ≥3, mixed cellularity subtype, and low response to treatment. Further, high c-Met expression correlated with increased age at diagnosis, leukocytosis, B symptoms, and lower chance to achieve complete remission. The sFLC levels correlated with increased age at diagnosis, lymphopenia, IPS ≥3, B symptoms, and lower complete remission rates. Conclusion In advanced cHL, increased expression of CD163 and c-Met showed a significant association with adverse prognostic parameters and poor response to treatment. Pretreatment high sFLC level also correlated with poor risk factors, suggesting its use as a candidate prognostic marker. A comprehensive approach for prognostic markers might represent a step towards developing a tailored therapeutic approach for HL.

Taphonomy and paleoecology of Cenomanian oysters from the Musabaa Salama area, southwestern Sinai, Egypt

Ahmed El-Sabbagh,Heba Mansour,Magdy El-Hedeny 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.4

This work is a taphonomic and paleoecologic study of Cenomanian oysters from the Musabaa Salama area, southwestern Sinai, Egypt. Disarticulation, fragmentation, encrustation and bioerosion are considered as the most predominant taphonomic features recorded in the studied oyster assemblages. Their distribution and frequency are greatly varied within the shells of the same species, as well as between shells of different species through the recorded oyster zones. Bioerosion structures include Tiers D, E, F, G and H. The multivariate statistical analyses document some characteristic ichnocoenoses. They include a sponge-dominated community (Entobia ichnocoenosis), a bivalve-dominated community (Gastrochaenolites ichnocoenosis), a serpulid-polychaete-dominated community (Maeandropolydora, Trypanites and/or Caulostrepsis ichnocoenosis), and an acrothoracican cirriped-dominated community (Rogerella ichnocoenosis). With rare exceptions, E. cretacea, G. torpedo and M. decipiens are common to abundant ichnospecies (>43%). E. ovula, E. retiformis and R. pattei are frequent to common ichnospecies (>5%). Other ichnospecies, including C. cretacea, G. orbicularis, T. solitarius, E. geometrica and C. taeniola are rare to frequent (<3%). Careful investigation of the host shells and the preserved encrusters and/or bioerosion sculptures provided data concerning the substrate characteristics, time of encrustation and bioerosion, rate of sedimentation, nutrients availability, and the general bathymetry and the rate of transgression.

CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin’s lymphoma

Magdy Bedewy,Shereen El-Maghraby,Ahmed Bedewy 대한혈액학회 2013 Blood Research Vol.48 No.2

Background Advances in the understanding of Hodgkin’s lymphoma (HL) show various functions of infiltrating immune cells and cytokines in relation to clinical outcomes. The expression of CD163 and c-Met has been suggested to have a role in lymphoid malignancy. Thus, we evaluated the expressions of CD163, c-Met, and serum free light chain (sFLC) in relation to the clinicopathological features of patients with advanced classical HL (cHL). Methods We assessed the expression of CD163 and c-Met in 34 patients with cHL through immunohistochemistry on the lymph node biopsy sections and the levels of pretreatment sFLC were estimated using ELISA. Results High CD163 expression correlated with increased age, B symptoms, International Prognostic Score (IPS) ≥3, mixed cellularity subtype, and low response to treatment. Further, high c-Met expression correlated with increased age at diagnosis, leukocytosis, B symptoms, and lower chance to achieve complete remission. The sFLC levels correlated with increased age at diagnosis, lymphopenia, IPS ≥3, B symptoms, and lower complete remission rates. Conclusion In advanced cHL, increased expression of CD163 and c-Met showed a significant association with adverse prognostic parameters and poor response to treatment. Pretreatment high sFLC level also correlated with poor risk factors, suggesting its use as a candidate prognostic marker. A comprehensive approach for prognostic markers might represent a step towards developing a tailored therapeutic approach for HL.

Prevalence of Eosinophilic Esophagitis in Adult Patients with Upper Gastrointestinal Symptoms in a Locality in Upper Egypt

Magdy Fouad,Yasser Mahrous Fouad,Hamdy Ahmed Mokareb,Dalia Mohammed Abdel-Rehim 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.4

Background/Aims: Eosinophilic esophagitis (EoE) is gaining importance in the diagnosis of upper gastrointestinal (UGI) symptoms. Diagnosis is based on the clinical presentation of esophageal dysfunction and pathological findings in the absence of other causes oftissue eosinophilia. Our study was designed to evaluate EoE prevalence in patients with UGI symptoms in our locality (El-Minia, Egypt). Methods: This single-center, cross-sectional study recruited all patients with UGI symptoms who agreed for endoscopic evaluation. Esophageal biopsy samples were obtained and histological evaluation for the presence of eosinophils was performed for every patient. EoE was defined when at least 15 eosinophils were present in a single high-power field, in the absence of other causes of esophagealeosinophilia. Results: Between 2013 and 2015, 218 of 476 adult patients with UGI symptoms underwent upper endoscopy after giving consent. Amongthe 218 patients, only 4 (1.87%) had the diagnosis of EoE based on the presence of eosinophils in esophageal biopsies and exclusion ofother causes of esophageal eosinophilia. Three patients with EoE presented mainly with dysphagia (75%) and/or other UGI symptoms,such as heartburn. Conclusions: We observed a low prevalence of EoE in our locality. The diagnosis of EoE should be considered in patients withdysphagia and/or heartburn.

Thermoelectric viscoelastic materials with memory-dependent derivative

Magdy A. Ezzat,Ahmed S. El Karamany,A.A. El-Bary 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.5

A mathematical model of electro-thermoelasticity has been constructed in the context of a new consideration of heat conduction with memory-dependent derivative. The governing coupled equations with time-delay and kernel function, which can be chosen freely according to the necessity of applications, are applied to several concrete problems. The exact solutions for all fields are obtained in the Laplace transform domain for each problem. According to the numerical results and its graphs, conclusion about the proposed model has been constructed. The predictions of the theory are discussed and compared with dynamic classical coupled theory. The result provides a motivation to investigate conducting thermoelectric viscoelastic materials as a new class of applicable materials.

Recovery of Tin as Tin oxide nanoparticles from waste printed circuit boards for photocatalytic dye degradation

Dina Magdy Abdo,Sabah Mohamed Abdelbasir,Shakinaz Taha El-Sheltawy,Ibrahim Ahmed Ibrahim 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.9

A simple eco-friendly process is proposed to retrieve tin from waste printed circuit boards (WPCBs) as tin oxide nanostructured powders. The WPCBs were leached in disodium salt of ethylene diamine tetraacetic acid (Na2- EDTA) chelating agent comparing results with acid leaching. Parameters affecting the leaching process such as sample particle size, pH, temperature, time, liquid/solid ratio, and concentration of Na2-EDTA were investigated. A 100% of Sn can be recovered by leaching in 0.1mol/L Na2-EDTA solution for 3 hours at 80 oC with optimum conditions of pH: 5, liquid/solid ratio: 30, particle size -0.07 mm, and constant stirring of 400 rpm. Kinetic data suggest a diffusion-controlled process as the rate-determining step for the Na2-EDTA extraction of tin from WPCBs with an activation energy of 15.28 KJ·mol-1. Selective precipitation of Sn as tin oxide (SnO2) nanoparticles (NPs) from leachant solution was performed via a simple route using sodium hydroxide. Characterization tests (XRD, FTIR, EDX, FE-SEM, and TEM) were made to confirm the morphology of the nanoparticles. The prepared SnO2 NPs, having a size range of 8-12nm, showed an excellent photocatalytic action towards methylene blue (MB) dye under ultraviolet (UV) light illumination with 90% efficiency after 180min and showed good reusability after five consecutive cycles.

Identification of Luteovirus Nucleotide Sequences in Mild Yellow-Edge Diseased Strawberry Plants

Shaban Montasser, Magdy,Al-Awadhi, Husain,Hadidi, Ahmed The Korean Society of Plant Pathology 2002 Plant Pathology Journal Vol.18 No.1

The availability of nucleotide sequences of the coat protein gene of Potato leafroll virus (PLRV) permitted the construction of DNA primers that were utilized for cDNA synthesis. Polymerase chain reaction (PCR) products of a 487 bp. and approximately 500 bp DNA fragments were amplified from nucleic acid extracts of PLRV-infected tissue and strawberry mild yellow-edge (SMYE) diseased strawberry tissue, respectively. The amplified DNA fragments were further differentiated by hybridization analysis with a CDNA probe for the coat protein gene of PLRV and restriction fragment length polymorphism (RFLP) analysis. These results suggest that a luteovirus is associated with the SMYE disease.

Nickel-cobalt alloy coatings prepared by electrodeposition Part II: Morphology, structure, microhardness, and electrochemical studies

Rasha Muneer Al Radadi,Magdy Ahmed Mahmoud Ibrahim 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.1

A study was carried out to synthesize Ni-Co alloy coatings electrochemically from complex acidic glycine (gly) bath. The impacts of some operating parameters such as Co2+ to Ni2+ concentration ratios in the bath, gly concentrations, pH, applied current, plating time and temperature on the morphology of Ni-Co alloy were investigated. The microstructure, microhardness, and electrochemical studies were also investigated. The electrochemical studies utilized cyclic voltammetry, anodic linear stripping voltammetry, and potentiostatic current-time transient techniques. It was realized that gly lowers the cathodic overvoltage for the Co2+ deposition while promoting cathodic overvoltage of Ni2+ deposition. Accordingly, the concurrent codeposition of Co2+ and Ni2+ ions was simplified. The morphology of Ni-Co alloy is significantly dependent on the operating parameters rather than on the bath composition. Moreover, increasing either pH or bath temperature produces Ni-Co deposits free from cracking. The roughness of the alloy is decreased in the presence of gly as shown by the atomic force microscope (AFM) study. In the presence of gly, the microhardness increases from 387 to 970 kg f mm2, i.e., it increased more than two-and-a-half times. On the other hand, X-ray diffraction analysis (XRD) data show that the crystallinity decreases with enhancing the percentage of cobalt in the deposits.