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RISS 인기검색어
- 검색키워드
- 저자 : Ahmad Reza Bahrami (검색결과 5 건)
- 무료
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PCR-based Identification of Aflatoxigenic Fungi Associated with Iranian Saffron
Reihaneh Noorbakhsh,Ahmad Reza Bahrami,Seyed Ali Mortazavi,Bita Forghani,Maesoomeh Bahreini 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.4
Aflatoxins are secondary metabolites produced by the aflatoxigenic fungi in suitable conditions. Saffron, Crocus sativus, is the most expensive spice in the world. Saffron is normally contaminated with soil and hand microflora during harvest and post-harvest operations. In this study, rapid assessment of aflatoxigenic fungi in saffron was accomplished using polymerase chain reaction. In total, 37 market samples were assayed in order to isolate aflatoxin-producing fungi. The 18.9% of the total samples were contaminated with aflatoxigenic fungi. Our results also show that most of the isolated fungi were saprophytes which are normally originated from soil during harvest and postharvest process.
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Maryam Dolatshahi,Ahmad Reza Bahrami,Qaiser Iftikhar Sheikh,Mohsen Ghanbari,Maryam M. Matin 대한약학회 2024 Archives of Pharmacal Research Vol.47 No.1
Gastric cancer (GC) is one of the most prevalent malignancies in the world, with a high mortality rate in both womenand men. Conventional treatments, like chemotherapy, radiotherapy and surgery, are facing some drawbacks like acquireddrug resistance and various side eff ects, leading to cancer recurrence and increased morbidity; thus, development of novelapproaches in targeted therapy would be very benefi cial. Exosomes, extracellular vesicles with a size distribution of sub-150 nm, interplay in physiological and pathophysiological cell–cell communications and can pave the way for targeted cancertherapy. Accumulating pieces of evidence have indicated that exosomes derived from mesenchymal stem cells (MSC-EXs)can act as a double-edged sword in some cancers. The purpose of this review is to assess the diff erences between stem celltherapy and exosome therapy. Moreover, our aim is to demonstrate how naïve MSCs transform into GC-MSCs in the tumormicroenvironment. Additionally, the tumorigenic and anti-proliferation eff ects of MSC-EXs derived from diff erent originswere investigated. Finally, we suggest potential modifi cations and combination options that involve utilizing MSC-EXs fromthe foreskin and umbilical cord as promising sources to enhance the effi cacy of gastric cancer treatment. This approach ispresented in contrast to bone marrow cells, which are more heterogeneous, age-related, and are also easily aff ected by thepatient's circulation system.
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Bracken-fern Extracts Induce Cell Cycle Arrest and Apoptosis in Certain Cancer Cell Lines
Roudsari, Motahhareh Tourchi,Bahrami, Ahmad Reza,Dehghani, Hesam,Iranshahi, Mehrdad,Matin, Maryam Moghadam,Mahmoudi, Mahmud Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12
Bracken fern [Pteridium aquilinem (L.) kuhn (Dennstaedtiaceae)] is one of the most common species on the planet. It has been consumed by humans and animals for centuries. Use by some human groups is because they believe bracken fern is good for health as plant medicine. However, it is also one of the few known plants that can cause tumors in farm animals. Many interested groups have focused their attention on bracken fern because of these interesting features. In order to evaluate the biological effects of exposure to this plant in cellular level, human cancer cell lines were treated with the fern dichloromethane extracts and the genotoxic and cytotoxic effects were studied. Anti-proliferative/cytotoxic effects were evaluated by cell count, MTT assay and flow cytometry methods with three different cancer cell lines, TCC, NTERA2, and MCF-7, and two normal cells, HDF1 and HFF3. Pro-apoptotic effects of the extracts were determined by DAPI staining and comet assay, on TCC cancer cells compared to the normal control cell lines. Cellular morphology was examined by light microscopy. Our present study showed that the extract caused DNA damage and apoptosis at high concentrations ($200{\mu}g/mL$) and also it may induce cell cycle arrest (G2/M phase) at mild concentrations (50 and $30{\mu}g/mL$) depending on the cell type and tumor origin. These results indicate that bracken fern extract is a potent source of anticancer compounds that could be utilized pharmaceutically.
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Expression of EIN2 Gene in Petunia Flowers is Down-regulated During Glucose Treatment
Amin Mirshamsi Kakhki,Faraj Shahriari,Ahmad Reza Bahrami,Julie Gray 한국원예학회 2009 Horticulture, Environment, and Biotechnology Vol.50 No.3
Glucose is a global regulator of growth and metabolism that is evolutionarily conserved from unicellular microorganisms to multi-cellular animals and plants. In photosynthetic plants, glucose shows hormone-like activities and modulates many essential processes, including embryogenesis, germination, seedling development, vegetative growth, reproduction and senescence. Expression analysis was carried out to evaluate the effect of glucose on ethylene biosynthesis and signaling in petunia flower. Flowers at the anthesis stage were treated with glucose solution and changes in ACS2, EIL-1 and EIN2 genes were monitored over time. While control flowers displayed a typical peak of ethylene production, flowers treated with glucose did not. Glucose appeared to exert its effect on ethylene biosynthesis by suppressing ACS2 expression. Interestingly, exposure to glucose treatment resulted in a rapid decrease in EIN2 expression in petals. However, EIN2 mRNA maintained to notably higher levels in petals of control flowers and decrease in mRNA level was slower than glucose-treated petals. Also, changes in EIL-1 mRNA levels in glucose-treated flowers showed that glucose delays increase of EIL-1 mRNA accumulation in petals. These results indicate that glucose may play an important role in ethylene-associated regulation of flower senescence.
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Chemokine Receptors Expression in MSCs: Comparative Analysis in Diff erent Sources and Passages
Asieh Heirani-Tabasi,Shirin Toosi,Mahdi Mirahmadi,Mohammad Amir Mishan,Hamid Reza Bidkhori,Ahmad Reza Bahrami,Javad Behravan,Hojjat Naderi-Meshkin 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.14 No.5
MSC-based therapy is providing a cure for degenerative diseases with unmet medical need and usually iliac crest bone marrow (ICBM) are being applied in clinics. Alternative sources, including adipose tissue and reamer/irrigator/ aspirator hold great potential for isolating MCSs. Here, we compared original MSCs features of adipose tissue (Ad-MSCs) and bone marrow of long-bone (RIA-MSCs) or iliac crest, and the expression of chemokine receptors (including CXCR4, CX3CR1, CXCR6, CXCR2, CCR1 and CCR7) in these three sources, which are important in the context of homing. We further investigated the role of SDF-1/CXCR4 axis as a key player in motility of different population of MSCs using Transwell migration assay. All cells exhibited typical MSCs characteristics. However, different MSCs sources expressed different levels of chemokine receptors. Generally, the expression of these chemokine receptors was decreased with increasing passage (P) number from 2 to 3. Interestingly, it was observed that the CXCR4 expression and migration capacity in Ad-MSCs is significantly higher than ICBM and RIA-MSCs in P2. Although our data showed that CXCR4 had highest expression in P2 Ad-MSCs, but it dramatically declined following sub-culturing in the P3. Hence, to improve homing of MSCs by means of chemokine/their receptors axis, the source of isolation and passage number should be considered for clinical applications.
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