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      • KCI등재

        Two-Level Anterior Cervical Discectomy and Fusion versus Hybrid Total Disc Replacement for Bilevel Pathology with Cervical Radiculopathy/Myelopathy: A Comparative Study with a Minimum 2-Year Follow-up in an Indian Population

        Sharma Jeevan Kumar,Varma Kalidindi Kalyan Kumar,Mallepally Abhinandan Reddy,Marathe Nandan,Rustagi Tarush,Mohapatra Bibhudendu,Yadav Padmini,Das Kalidutta 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.4

        Study Design: Retrospective study. Purpose: To study the outcomes of two-level anterior cervical discectomy and fusion (2L-ACDF) versus hybrid total disc replacement (H-TDR) for cervical myeloradiculopathy. Overview of Literature: For bilevel disc issues of the cervical spine, 2L-ACDF has been a historical tool with numerous implants used at different time frames. Recent developments in total disc replacement at mobile level with fusion at a spondylotic level known as hybrid fixation have added a new armamentarium for such disorders. Methods: An analysis of 49 consecutive patients who underwent 2L-ACDF (n=22) and H-TDR (n=27) from January 1, 2014 to December 31, 2017 was performed. Data were studied as retrieved from InstaPACS ver. 4.0 (Mediff Technologies Pvt. Ltd., Bengaluru, India) and medical records. Results: Twenty-two patients with 2L-ACDF and 27 patients with H-TDR were included. The mean±standard deviation (SD) follow-up duration was 4.0±1.5 years in H-TDR and 3.1±1.1 years in 2L-ACDF. The mean±SD Neck Disability Index (NDI) decreased from 26.1±7.6 to 6.5±3.9 in the H-TDR group and from 27.6±7.2 to 6.4±4.8 in the 2L-ACDF group at final follow-up. Disc height at suprajacent level in the 2L-ACDF group was 4.12±0.48 mm, 4.10±0.45 mm, and 4.05±0.48 mm preoperatively, at 1-year, and final follow-up, respectively. Disc height at supradjacent level in the H-TDR group was 4.28±0.36 mm, 4.20±0.32 mm, and 4.19±0.34 mm preoperatively, at 1-year, and final follow-up, respectively. Conclusions: There was significantly improved NDI in both groups. Adjacent segment disc height loss was greater in the 2L-ACDF group than in H-TDR but not statistically significant (p=0.304). Supradjacent segment range of motion was greater in the 2L-ACDF group than in the H-TDR group (p=0.003). Both findings supported radiographic adjacent segment degeneration (ASD), but symptomatic ASD was absent in both groups.

      • KCI등재

        An overview of converting reductive photocatalyst into all solid-state and direct Z-scheme system for water splitting and CO2 reduction

        Pankaj Raizada,Abhinandan Kumar,Vasudha Hasija,Pardeep Singh,Vijay Kumar Thakur,Aftab Aslam Parwaz Khan 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-

        Considering the current scenario of rising environmental and energy concerns, engineering of Z-schemephotocatalytic systems is in the spotlight. The prime reason for this includes efficient redox abilities andeffective space separation along with the migration of photoinduced charge carriers over conventionalheterojunction systems. Herein we foreground the stumbling blocks of traditional heterojunctionsystems and enlighten the generations of Z-scheme photocatalysis originating from liquid-phase todirect Z-scheme photocatalytic systems. We provide substantial criteria and selection aspects ofchoosing reductive type photocatalysts as a potential aspirant for the Z-scheme photocatalytic system. AsZ-scheme photocatalytic systems render effective space separation of photogenerated carriers, activespecies generation, wide optical absorption and amended redox ability. We focus on comprehensiveillustration of all solid-state and direct Z-scheme photocatalysts by coupling reductive typephotocatalysts with other semiconductor material and explored their potential for efficacious conversionof solar energy into functional energy. Herein, we aim to provide in-depth and updated criteria forselecting Z-scheme photocatalysts for CO2 reduction, water splitting, and nitrogenfixation. Lastly, thearticle compiles with a conclusive note about future perspectives and challenges accompanying all solidstateand direct Z-scheme Z photocatalysts and their energy conversion applications.

      • KCI등재

        Advanced strategies for modifying the water splitting performance of MoSe2 photocatalyst: A critical review of recent progress

        Vaishnavi Sharma,Abhinandan Kumar,Pardeep Singh,Praveen Kumar Verma,Tansir Ahamad,Sourbh Thakur,Quyet Van Le,Van Huy Nguyen,Aftab Aslam Parwaz Khan,Pankaj Raizada 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

        Water splitting technology is rapidly evolving in order to generate H2 in a sustainable manner to amendthe global energy crisis. Water splitting over semiconductor catalyst nanoparticles for large-scale hydrogenproduction has shown to be a simple and affordable procedure, attracting researchers from aroundthe world for more fruitful studies and development in the field of photocatalysis. In this respect,MoSe2 is a promising semiconductor photocatalyst owing to its non-toxic nature, low Gibbs free energy,high metallic character, impressive opto-electronic properties, and outstanding photocatalytic performance. Moreover, the 2D nature of MoSe2 allows the easy tuning of the bandgap to suit H2 evolution reactionapplication by simple synthesis techniques. Therefore, in this review, we have comprehensivelydiscussed the influence of morphology on photocatalytic water splitting with a main focus on the nanostructuremodifications to modulate the properties of MoSe2. In detail, starting from the crystal structureand optimal photocatalytic features of MoSe2, insights into photocatalytic water splitting have been highlighted. Various modes of nanostructure designs involving hydro(solvo)thermal, CVD, PVD, exfoliation,and intercalation are outlined. The lower bandgap energy is subjected to a high rate of photoinducedexcitons recombination, which reduces its photocatalytic efficiency. Therefore, modification techniquessuch as doping, heterostructure construction, and vacancy generation are presented in order to concurrentlyimprove the photocatalytic water splitting performance. Finally, the study concludes with a summaryof recent advancements and anticipated potential trends in this area to instigate further researchendeavours.

      • MDM2 and TP53 Polymorphisms as Predictive Markers for Head and Neck Cancer in Northeast Indian Population: Effect of Gene-Gene and Gene-Environment Interactions

        Bhowmik, Aditi,Das, Sambuddha,Bhattacharjee, Abhinandan,Choudhury, Biswadeep,Naiding, Momota,Deka, Sujata,Ghosh, Sankar Kumar,Choudhury, Yashmin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

        Background: Polymorphisms in the MDM2 309 (T>G) and TP53 72 (G>C) genes are reported to increase the susceptibility to head and neck cancer (HNC) in various populations. The risk for HNC is also strongly associated with etiologic habits such as smoking, alcohol consumption and/or chewing of betel quid (BQ). In a case-control study, we investigated the significance of the above polymorphisms alone, and upon interaction with one another as well as with various etiologic habits in determining HNC risk in a Northeast Indian population. Materials and Methods: Genotyping at 309 MDM2 and 72 TP53 in 122 HNC patients and 86 cancer free healthy controls was performed by PCR using allele specific primers, and the results were confirmed by DNA sequencing. Results: Individuals with the GG mutant allele of MDM2 showed a higher risk for HNC in comparison to those with the TT wild type allele (OR=1.9, 95%CI: 1.1-3.3) (p=0.022). The risk was further increased in females by ~4-fold (OR=4.6, 95% CI: 1.1-19.4) (P=0.04). TP53 polymorphism did not contribute to HNC risk alone; however, interaction between the TP53 GC and MDM2 GG genotypes resulted in significant risk (OR=4.9, 95% CI: 0.2-105.1) (p=0.04). Smokers, BQ- chewers and alcohol consumers showed statistically significant and dose-dependent increase in HNC risk, irrespective of the MDM2 genotype. Conclusions: MDM2 genotype could serve as an important predictive biomarker for HNC risk in the population of Northeast India.

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