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Complex Nonequilibrium Flows with Slow and Fast Chemical Reactions studied by Kinetic Methods
V.V.Aristov,A.A.Frolova,S.A.Zabelok 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10
The present paper studies complex nonequilibrium flows on the basis of the kinetic equations taking into account chemical reactions. Both slow and fast (for which mechanical and chemical relaxation time are of the same order of a magnitude) chemical reactions are considered. Our work is directed towards studying 1D and 2D Nonuniform Relaxation Problems (NRP). The algorithm for numerical simulations in the gases with chemical reactions is implemented within Unifiied Flow Solver (UFS). Flows with the ordinary and anomalous transport properties are investigated for several variants of chemical reactions parameters. A special attention is paid to consideration of the entropy. Comparison of the local magnitudes of nonequilibrium and equilibrium entropy is performed. The value of nonequilibrium entropy provides a characteristics of the complexity of these open systems. This study is focused on nonequilibrium processes keeping in mind simulation of flows in real natural systems.
Yunusova, Natalia V,Villert, Alisa B,Spirina, Liudmila V,Frolova, Alena E,Kolomiets, Larisa A,Kondakova, Irina V Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in primary tumors and ascites as predictors of response to neoadjuvant chemotherapy in ovarian cancer (OC) patients. Materials and Methods: Tumor tissue samples and ascitic fluid were obtained from 59 patients with advanced OC. The levels of IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A were determined using ELISA kits. Taking into account the data on expression of these IGF-related proteins and outcome, logistic regression was performed to identify predictors of response to neoajuvant chemotherapy. Results: Human ovarian tumors expressed IGFs, IGFBP-3, IGFBP-4 and PAPP-A and these proteins were also present in ascites fluid and associated with its volume. IGFs and IGFBPs in ascites and soluble PAPP-A might play a key role in ovarian cancer progression. However, levels of proteins of the IGF system in tumors were not significant predictors of objective clinical response (oCR). Univariate analysis showed that the level of IGF-I in ascites was the only independent predictor for oCR. Conclusion: The level of IGF-I in ascites was shown to be an independent predictor of objective clinical response to chemotherapy for OC patients treated with neoadjuvant chemotherapy and debulking surgery.