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Spin excitations in cubic maghemite nanoparticles studied by time-of-flight neutron spectroscopy
Disch, S.,Hermann, R. P.,Wetterskog, E.,Podlesnyak, A. A.,An, K.,Hyeon, T.,Salazar-Alvarez, G.,Bergströ,m, L.,Brü,ckel, Th. American Physical Society 2014 Physical review. B, Condensed matter and materials Vol.89 No.6
We have determined the field dependence of collective magnetic excitations in iron oxide nanoparticles of cubic shape with 8.42(2) nm edge length and a narrow log normal size distribution of 8.2(2)% using time-of-flight neutron spectroscopy. The energy dependence of the uniform precession modes was investigated up to 5 T applied field and yields a Lande factor g = 2.05(2) as expected for maghemite (gamma-Fe2O3) nanoparticles. A large effective anisotropy field of B-A,B-eff = 0.45(16) T was determined, in excellent agreement with macroscopic measurements. This anisotropy is attributed to enhanced shape anisotropy in these monodisperse cubic nanoparticles. The combination of our results with macroscopic magnetization information provides a consistent view of the energy scales of superparamagnetic relaxation and collective magnetic excitations in magnetic nanoparticles.
Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors
Han, D.,Tapia, N.,Hermann, A.,Hemmer, K.,Hoing, S.,Arauzo-Bravo, Marcos J.,Zaehres, H.,Wu, G.,Frank, S.,Moritz, S.,Greber, B.,Yang, J.,Lee, H.,Schwamborn, Jens C.,Storch, A.,Scholer, Hans R. Cell Press 2012 Cell stem cell Vol.10 No.4
Recent studies have shown that defined sets of transcription factors can directly reprogram differentiated somatic cells to a different differentiated cell type without passing through a pluripotent state, but the restricted proliferative and lineage potential of the resulting cells limits the scope of their potential applications. Here we show that a combination of transcription factors (Brn4/Pou3f4, Sox2, Klf4, c-Myc, plus E47/Tcf3) induces mouse fibroblasts to directly acquire a neural stem cell identity-which we term as induced neural stem cells (iNSCs). Direct reprogramming of fibroblasts into iNSCs is a gradual process in which the donor transcriptional program is silenced over time. iNSCs exhibit cell morphology, gene expression, epigenetic features, differentiation potential, and self-renewing capacity, as well as in vitro and in vivo functionality similar to those of wild-type NSCs. We conclude that differentiated cells can be reprogrammed directly into specific somatic stem cell types by defined sets of specific transcription factors.
Si(0 0 1) surface optical anisotropies induced by π-conjugated overlayers and oxidation
W.G. Schmidt,A. Hermann,F. Fuchs,F. Bechstedt 한국물리학회 2006 Current Applied Physics Vol.6 No.3
A density functional (DFT–GGA) study on the modification of the Si(001) surface optical response upon adsorption of 9,10-phenanthrenequinone and oxidation is presented. In the first case it is found that intramolecular p–p* transitions as well as adsorption-modified Si bulk states contribute to the optical signal. The molecular contributions differ strongly from the respective signals of gas-phase molecules, indicating the need for a cautious interpretation of experimental data. The calculations for oxidized Si structures show that local Si lattice deformations accompanying the oxidation of Si bulk bonds directly at the silicon–silicon oxide interface give rise to pronounced optical anisotropies that explain the experimental findings very well. In contrast, calculations for translationally invariant oxide structures fail to reproduce the experiment. This indicates the oxidation to occur layer-by-layer and strong disorder of the silicon oxide layers immediately above the interface.
Magnetron Sputtering 에 의한 질화물 증착의 반응속도론
김종희,Jehn, Hermann A 대한금속재료학회(대한금속학회) 1992 대한금속·재료학회지 Vol.30 No.1
ZrN_x, NbN_x, and MoN_x coatings were deposited onto high speed steel substrates by reactive dc magnetron sputtering in an argon-nitrogen atmosphere. The target and substrate surface reactions were described in order to explain experimental results on the deposition rate and coating composition as a function of the nitrogen partial pressure. As a result of the reactions the target contamination, the sputter yield of the contaminated target surface, and the formal reaction coefficients of gaseous nitrogen with the deposited metal atoms were obtained. Special emphasis was laid on the effect of the position of the metals in the periodic system of elements. The reactivity was strongly governed by the thermochemistry of the respective metal-nitrogen systems.
Analysis of Lyso-Globotriaosylsphingosine in Dried Blood Spots
Britt Johnson,Hermann Mascher,Daniel Mascher,Elisa Legnini,Christina Y Hung,Angela Dajnoki,Yin-Hsiu Chien,László Maródi,Wuh-Liang Hwu,Olaf A Bodamer 대한진단검사의학회 2013 Annals of Laboratory Medicine Vol.33 No.4
Recently, lyso-globotriaosylsphingosine (lyso-Gb3) was found to be elevated in plasma of treatment naive male patients and some female patients with Fabry Disease (FD). This study tested whether lyso-Gb3 could be analyzed in dried blood spots (DBS) from filter cards and whether concentrations are elevated in newborn infants with FD. Lyso-Gb3 concentrations were analyzed in DBS following extraction using a novel HPLC-mass spectrometry (MS)/MS method. Lyso-Gb3 levels in DBS were above the lower limit of quantitation (0.28 ng/mL) in 5/17 newborn FD infants (16 males; range: 1.02-8.81 ng/mL), but in none of the newborn controls, in all 13 patients (4 males) with classic FD (range: 2.06-54.1ng/mL), in 125/159 Taiwanese individuals with symptomatic or asymptomatic FD who carry the late onset α-galactosidase A (GLA) mutation c.936+919G>A (IVS4+919G>A) (3.75±0.69 ng/mL; range: 0.418-3.97 ng/mL) and in 20/29 healthy controls (0.77±0.24 ng/mL;range: 0.507-1.4 ng/mL). The HPLC-MS/MS method for analysis of lyso-Gb3 is robust and yields reproducible results in DBS in patients with FD. However, concentrations of lyso-Gb3 were below the limit of quantitation in most newborn infants with FD rendering this approach not suitable for newborn screening. In addition, most females with the late onset mutation have undetectable lyso-Gb3 concentrations.
R. Adam Rebeles,A. Hermanne 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Excitation functions of deuteron induced reactions on natural thallium, leading to the formation of the ^(204m,203,202m)Pb, ^(202)Tl isotopes, were studied by the stacked foil activation technique. Reaction cross sections were measured from their respective thresholds up to E_d = 21 MeV. Quantification of induced isotopes has been made by gamma spectrometry. Where available, the experimental cross sections are compared with values reported previously in literature. Based on the discrete values of the measured cross section, thick target yield for the medically interesting radionuclide ^(203)Pb is calculated.
Recommended nuclear data for medical radioisotope production: diagnostic positron emitters
Tá,rká,nyi, F. T.,Ignatyuk, A. V.,Hermanne, A.,Capote, R.,Carlson, B. V.,Engle, J. W.,Kellett, M. A.,Kibé,di, T.,Kim, G. N.,Kondev, F. G.,Hussain, M.,Lebeda, O.,Luca, A.,Nagai, Y.,Na Springer-Verlag 2019 Journal of Radioanalytical and Nuclear Chemistry Vol.319 No.2
miRNA-mediated Expression Switch of Cell Adhesion Genes Driven by Microcirculation in Chip
Timur R Samatov,Vladimir V Galatenko,Nadezhda V Senyavina,Alexey V Galatenko,Maxim Yu Shkurnikov,Svetlana A Tonevitskaya,Dmitry A Sakharov,Uwe Marx,Hermann Ehrlich,Udo Schumacher,Alexander G Tonevitsk 한국바이오칩학회 2017 BioChip Journal Vol.11 No.4
Changes in cell adhesion molecule (CAM) expression and miRNAs regulating them are known to be involved in malignant progression in colon cancer. We investigated expression profiles of CAM genes and non-coding RNAs in CaCo2 colon cancer cells in static culture and under dynamic flow conditions perfused in microfluidic chip emulating physiological microenvironment. We incubated monolayers of CaCo2 cells in Transwell® units either under static conditions or under flow in a microfluidic chip. We identified 7 up-regulated CAM genes (CD44, CDH7, CEACAM5, CEACAM6, CYR61, L1CAM and VCAN), 7 down-regulated genes (COL12A1, FGA, FGB, FGG, GJA1, ITGA5 and LAMA1) and 69 miRNAs targeting them under the influence of microcirculation. The revealed network comprised CAM genes known to interact with each other and 13 miRNAs simultaneously regulating more than one of them. The discovered regulatory network comprising CAM genes and miRNAs is likely involved in normal functioning of intestine epithelium as well as in cancer progression.