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폐경후 여성에서 에스트로겐 치료에 대한 혈중 지질의 반응과 에스트로겐 수용체 다형성과의 관계
황정규,한인권,장학철,임창훈,정호연,한기옥,윤현구,박재은,박소라,정필호 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.3
Backgound: Several biologically plausible mechanisms have been proposed for estrogen-mediated caridoprotection, including estrogen-assocaited changes in lipid metabolism and endothelial function of vessel walls. These effects are thought to be mediated via estrogen receptor (ER). Relationships between ER polymorphisms and serum lipid levels were not investigated enoughly. Methods: Three restriction fragment length polymorphisms (RFLPs) at the ER gene locus, represented as B-variant, PvuII and XbaI, and their relationship to serum lipid levels were examined in 318 postmenopausal women. Their mean age was 54.5±6.5 years (mean+SD). An association between ER genotypes and changes in lipid levels after 1 year of estrogen replacement therapy was also investigated in follow-up 251 women. Results: The B-variant was not found in Korean women. The distribution of the PvuII and XbaI polymorphisms was as follows: PP 109 (34%), Pp 166 (52%), pp 43 (14%), and XX 204 (64%), Xx 95 (30%), xx 19 (6%). Significant relationshipwas found between genotypes and changes in serum total cholesterol levels after lyr estrogen replacement therapy. There was no significant relationship between ER genotypes and changes in HDL cholesterol, LDL cholesterol and triglyceride levels after estrogen therapy. Conclusion: These data indicate that these polymorphisms are possible predictor on lipid response to estrogen replacement therapy (J Kor Soc Endocrinol 14:553-561, 1999).